A5058341243- Neuroscience of respiration and sleep
- Spinal Cord Injury Research
- Advanced Sensor and Energy Harvesting Materials
- Pain Mechanisms and Treatments
- Muscle activation and electromyography studies
- Neuroscience and Neuropharmacology Research
- Obstructive Sleep Apnea Research
- Neuroscience and Neural Engineering
- Adipose Tissue and Metabolism
- Cerebral Palsy and Movement Disorders
- Pain Management and Placebo Effect
- Infant Health and Development
- Acupuncture Treatment Research Studies
- Advanced Chemical Sensor Technologies
- Advanced Materials and Mechanics
- Biochemical and Structural Characterization
- Nanoparticle-Based Drug Delivery
- Zebrafish Biomedical Research Applications
- Nicotinic Acetylcholine Receptors Study
- Healthcare and Venom Research
- Thin-Film Transistor Technologies
- Electrochemical sensors and biosensors
- Stroke Rehabilitation and Recovery
- Heart Rate Variability and Autonomic Control
- Neurological Disorders and Treatments
University of California, Los Angeles
2016-2025
Peking University
2024
UCLA Health
2021
Heilongjiang University of Chinese Medicine
2016
Fudan University
2014
Abstract Central nervous system (CNS) diseases are the leading cause of morbidity and mortality; their treatment, however, remains constrained by blood–brain barrier (BBB) that impedes access most therapeutics to brain. A CNS delivery platform for protein therapeutics, which is achieved encapsulating proteins within nanocapsules contain choline acetylcholine analogues, reported herein. Mediated nicotinic receptors transporters, such can effectively penetrate BBB deliver CNS, as demonstrated...
Advancing electronics to interact with tissue necessitates meeting material constraints in electrochemical, electrical, and mechanical domains simultaneously. Clinical bioelectrodes established electrochemical functionalities are rigid mechanically mismatched tissue. Whereas conductive materials tissue-like softness stretchability demonstrated, when applied electrochemically probe tissue, their performance is distorted by strain corrosion. We devise a layered architectural composite design...
The advent of 6G communication demands seamlessly integrated terminals operating above 100 GHz with low power consumption for human-centric applications. In this work, we report high-performance, flexible radio-frequency (RF) transistors based on aligned carbon nanotube (CNT) arrays, achieving, the first time, as-measured current gain cutoff frequency ($f_{\mathrm{T}}$) and ($f_{\mathrm{max}}$) both exceeding GHz. Electro-thermal co-design improves heat dissipation RF performance, despite...
Mimicking metabolic pathways on electrodes enables in vivo metabolite monitoring for decoding metabolism. Conventional sensors cannot accommodate underlying complex reactions involving multiple enzymes and cofactors, addressing only a fraction of enzymatic few metabolites. We devised single-wall-carbon-nanotube-electrode architecture supporting tandem pathway–like linkable to oxidoreductase-based electrochemical analysis, making vast majority metabolites detectable vivo. This robustly...
SIP30 (SNAP25 interacting protein of 30) is a SNAP25 interaction 30 kDa that functions in neurotransmitter release. Using chronic constriction injury (CCI) model neuropathic pain, we profiled gene expression the rat spinal cord and brain identified sip30 , which was upregulated after CCI. Here, show CCI induced bilateral increase rostral anterior cingulate cortex (rACC), key region has been implicated pain affect. We put rats chamber with one half painted white (light area) other black (dark...
Spinal cord stimulation enhanced restoration of motor function following spinal injury (SCI) in unblinded studies. To determine whether training combined with transcutaneous electrical (tSCS), or without systemic serotonergic treatment buspirone (busp), could improve hand individuals severe paralysis SCI, we assessed ten subjects a double-blind, sham-controlled, crossover study. All treatments-busp, tSCS, and the busp plus tSCS-reduced muscle tone spasm frequency. Buspirone did not have any...
The peripheral nervous system may play an important role in normal bone maintenance and remodeling. Substance P (SP) is a neuropeptide associated with loss formation that mediate the effects of system. purpose this study to determine if treadmill running combined electro-acupuncture at Jiaji acupoints (Jiaji-EA) affects tibial mass SP expression rabbits sciatic nerve injury. Twenty-four juvenile male New Zealand white were randomly assigned one 4 groups: sham injury control (sham), never...
There is increased interest in ultrathin flexible devices with thicknesses of <1 micrometers due to excellent conformability toward advanced laminated bioelectronics. However, because limitations materials, device structure, and fabrication methodology, the performance these circuits insufficient support higher-level applications. Here, we report high-performance carbon nanotube–based thin-film transistors (TFTs) differential amplifiers on polyimide films a total thickness <180...
Abstract Motor deficits are observed in Alzheimer’s disease (AD) prior to the appearance of cognitive symptoms. To investigate role amyloid proteins gait disturbances, we characterized locomotion APP-overexpressing transgenic J20 mice. We used three-dimensional motion capture characterize quadrupedal on a treadmill and wild-type Sixteen mice fifteen were studied at two ages (4- 13-month). A random forest (RF) classification algorithm discriminated between genotypes within each age group...
Respiration is produced and controlled by well-characterized brain stem nuclei, but the contributions of spinal circuits to respiratory control modulation remain under investigation. Many studies are conducted in vitro preparations (e.g., slice) obtained from neonatal rodents. While informative, these do not fully recapitulate complex afferent efferent neural that likely be involved eupnea (i.e., quiet breathing). To begin investigate respiration, we electrically stimulated cervical cord...
Abstract Opioid overdose suppresses brainstem respiratory circuits, causes apnoea and may result in death. Epidural electrical stimulation (EES) at the cervical spinal cord facilitated motor activity rodents humans, we hypothesized that EES of could antagonize opioid‐induced depression humans. Eighteen patients requiring surgical access to dorsal surface between C2 C7 received or sham for up 90 s 5 30 Hz during complete (OFF‐State) partial suppression (ON‐State) respiration induced by...
Recent studies suggest that epidural stimulation of the spinal cord could increase motor pattern both in and sensory complete injury (SCI) patients. However, choosing optimal variables, such as frequency, intensity, location stimulation, significantly affects maximal functionality. This paper presents a novel technique using machine learning methods to predict functionality SCI patient after stimulation. Additionally, we committee-based active method reduce number clinical experiments...
Spinal cord epidural electrical stimulation (EES) has emerged as a novel approach to modulate and interrogate the neural circuit(s) underlying sensorimotor functions in past few decades. Recent studies have revealed that cervical EES can regulate respiration both human subjects animal models. Furthermore, coupled lumbar stimulations significantly increased rhythmic motor outputs spinal cord. We hypothesize coupling is underpinned by cervico-lumbar synaptic connections, thus, at level of...
A universal central nervous system (CNS)-delivery platform is developed enabling the delivery of protein therapeutics to brain via choline transporters and acetylcholine receptors. In article number 1807557, Zhanlong He, Jing Wen, Wei Chen, Yunfeng Lu, co-workers demonstrate that can effectively penetrate blood–brain barrier in mice nonhuman primates by encapsulating proteins within nanocapsules with analogues.
We tested the hypothesis that dorsal cervical epidural electrical stimulation (CEES) increases respiratory activity in male and female anesthetized rats. Respiratory frequency minute ventilation were significantly increased when CEES was applied dorsally to C2–C6 region of spinal cord. By injecting pseudorabies virus into diaphragm using c-Fos identify neurons activated during CEES, we found horn cord which co-localized, these expressed somatostatin (SST). Using dual viral infection express...
Objective To observe the effects of electro-acupuncture on Jiaji acupoints combine with treadmill training tibia bone mass rabbits sciatic nerve injury, so as to provide theoretical support for better project maintain normal metabolism after peripheral injury. Methods A total 24 New Zealand were randomly divided into four groups (n=6), namely a model group, sham group and an + according random number table. The in model, was clamped using hemostatic forceps establish while that not...
Opioid overdose is one of the leading causes related deaths in United States America, accounting for 70.6% fatalities 2019 alone. A cause death among opioid overdoses respiratory depression. Epidural electrical stimulation (EES) emerges as a novel approach facilitating rhythmic motor activities such locomotion and respiration. Previous studies conducted humans rodent models demonstrated augmentations induced by EES delivered to dorsal cervical spinal cord. Importantly, at cord opposes...
Abstract In patients with chronic spinal cord injury (SCI), few therapies are available to improve neurological function. Neuromodulation of the epidural stimulation (EDS) has shown promise enabling voluntary activation motor pools caudal level injury. EDS is performed multiple electrode arrays in which several variables such as frequency, amplitude, and location significantly affect type amplitude responses. This paper presents a novel technique predict final functionality patient SCI after...
Motor deficits are observed in Alzheimer's disease (AD) prior to the appearance of cognitive symptoms. To investigate role amyloid proteins gait disturbances, we characterized locomotion APP-overexpressing transgenic J20 mice. We used three-dimensional motion capture characterize quadrupedal on a treadmill and wild-type Sixteen mice fifteen were studied at two ages (4- 13-month). A random forest (RF) classification algorithm discriminated between genotypes within each age group using...