A5078723386- Neuroscience of respiration and sleep
- Obstructive Sleep Apnea Research
- Spinal Cord Injury Research
- Neuroscience and Neural Engineering
- EEG and Brain-Computer Interfaces
- Vagus Nerve Stimulation Research
- Spine and Intervertebral Disc Pathology
- Heart Rate Variability and Autonomic Control
- Spinal Hematomas and Complications
- Infant Health and Development
- Advanced Sensor and Energy Harvesting Materials
- Conducting polymers and applications
- Restraint-Related Deaths
- Muscle activation and electromyography studies
University of California, Los Angeles
2022-2024
University of Colorado Anschutz Medical Campus
2023
Advancing electronics to interact with tissue necessitates meeting material constraints in electrochemical, electrical, and mechanical domains simultaneously. Clinical bioelectrodes established electrochemical functionalities are rigid mechanically mismatched tissue. Whereas conductive materials tissue-like softness stretchability demonstrated, when applied electrochemically probe tissue, their performance is distorted by strain corrosion. We devise a layered architectural composite design...
Spinal cord stimulation enhanced restoration of motor function following spinal injury (SCI) in unblinded studies. To determine whether training combined with transcutaneous electrical (tSCS), or without systemic serotonergic treatment buspirone (busp), could improve hand individuals severe paralysis SCI, we assessed ten subjects a double-blind, sham-controlled, crossover study. All treatments-busp, tSCS, and the busp plus tSCS-reduced muscle tone spasm frequency. Buspirone did not have any...
Abstract Opioid overdose suppresses brainstem respiratory circuits, causes apnoea and may result in death. Epidural electrical stimulation (EES) at the cervical spinal cord facilitated motor activity rodents humans, we hypothesized that EES of could antagonize opioid‐induced depression humans. Eighteen patients requiring surgical access to dorsal surface between C2 C7 received or sham for up 90 s 5 30 Hz during complete (OFF‐State) partial suppression (ON‐State) respiration induced by...
Spinal cord epidural electrical stimulation (EES) has emerged as a novel approach to modulate and interrogate the neural circuit(s) underlying sensorimotor functions in past few decades. Recent studies have revealed that cervical EES can regulate respiration both human subjects animal models. Furthermore, coupled lumbar stimulations significantly increased rhythmic motor outputs spinal cord. We hypothesize coupling is underpinned by cervico-lumbar synaptic connections, thus, at level of...
We tested the hypothesis that dorsal cervical epidural electrical stimulation (CEES) increases respiratory activity in male and female anesthetized rats. Respiratory frequency minute ventilation were significantly increased when CEES was applied dorsally to C2–C6 region of spinal cord. By injecting pseudorabies virus into diaphragm using c-Fos identify neurons activated during CEES, we found horn cord which co-localized, these expressed somatostatin (SST). Using dual viral infection express...
A 3-year-old boy presented to the emergency department with torticollis after a fall. With normal cervical radiographs and neurologic exam, he was diagnosed strain discharged. After 2-week progressive symptoms, referred pediatric spine surgeon. Magnetic resonance imaging (MRI) revealed epidural hematoma, which then surgically evacuated. He recovered fully remains symptom-free 2 years later.Pediatric spinal hematoma is rare condition potentially serious outcomes yet often nonspecific...
Opioid overdose is one of the leading causes related deaths in United States America, accounting for 70.6% fatalities 2019 alone. A cause death among opioid overdoses respiratory depression. Epidural electrical stimulation (EES) emerges as a novel approach facilitating rhythmic motor activities such locomotion and respiration. Previous studies conducted humans rodent models demonstrated augmentations induced by EES delivered to dorsal cervical spinal cord. Importantly, at cord opposes...