A5023907155- Spinal Cord Injury Research
- Nerve Injury and Rehabilitation
- Transcranial Magnetic Stimulation Studies
- Muscle activation and electromyography studies
- Urinary Bladder and Prostate Research
- Stroke Rehabilitation and Recovery
- Pelvic floor disorders treatments
- Neuroscience and Neural Engineering
- EEG and Brain-Computer Interfaces
- Cerebral Palsy and Movement Disorders
- Neuroscience of respiration and sleep
- Spinal Dysraphism and Malformations
- Urinary Tract Infections Management
- Botulinum Toxin and Related Neurological Disorders
- Pain Management and Treatment
- Vagus Nerve Stimulation Research
- Motor Control and Adaptation
- Neurological disorders and treatments
- Urological Disorders and Treatments
- Wireless Power Transfer Systems
- Obstructive Sleep Apnea Research
- Neurobiology and Insect Physiology Research
- Balance, Gait, and Falls Prevention
- Zebrafish Biomedical Research Applications
- Prostate Cancer Treatment and Research
University of Southern California
2020-2023
University of California, Los Angeles
2014-2023
Rancho Research Institute
2020-2023
Rancho Los Amigos National Rehabilitation Center
2018-2023
University of Technology Sydney
2019-2020
Terasaki Foundation
2015
University of California System
2015
Ottawa Hospital
2003
Uppsala University
1990
The present prognosis for the recovery of voluntary control movement in patients diagnosed as motor complete is generally poor. Herein we introduce a novel and noninvasive stimulation strategy painless transcutaneous electrical enabling pharmacological to neuromodulate physiological state spinal cord. This neuromodulation enabled locomotor networks individuals with paralysis 2-6 years American Spinal Cord Injury Association Impairment Scale (AIS) be re-engaged trained. We showed that...
Upper extremity function is the highest priority of tetraplegics for improving quality life. We aim to determine therapeutic potential transcutaneous electrical spinal cord stimulation restoration upper function. tested hypothesis that cervical can facilitate neuroplasticity results in long-lasting improvement motor control. A 62-year-old male with C3, incomplete, chronic injury (SCI) participated study. The intervention comprised three alternating periods: 1) combined physical therapy (PT);...
Paralysis of the upper extremities following cervical spinal cord injury (SCI) significantly impairs one's ability to live independently. While regaining hand function or grasping is considered one most desired functions in tetraplegics, limited therapeutic development this direction has been demonstrated date humans with a high severe injury. The underlying hypothesis that after SCI, nonfunctional sensory-motor networks within can be transcutaneously neuromodulated physiological states...
We asked whether coordinated voluntary movement of the lower limbs could be regained in an individual having been completely paralyzed (>4 year) and absent vision (>15 using two novel strategies-transcutaneous electrical spinal cord stimulation at selected sites over spine as well pharmacological neuromodulation by buspirone. also these neuromodulatory strategies facilitate stepping assisted exoskeleton (EKSO, EKSO Bionics, CA) that is designed so subject can voluntarily complement work...
Abstract Background Stimulation of the spinal cord has been shown to have great potential for improving function after motor deficits caused by injury or pathological conditions. Using a wide range animal models, many studies that stimulation applied neural networks intrinsic can result in dramatic improvement ability, even allowing an step and stand complete transection. Clinical use this technology, however, slow develop due invasive nature implantation procedures, lack versatility...
Neuromodulation is a therapeutic technique that well-established in the treatment of idiopathic Lower urinary tract (LUT) dysfunction such as overactive bladder (OAB). We have recently developed novel neuromodulation approach, Transcutaneous Electrical Spinal Cord (TESCoN) and demonstrated its acute effects on LUT after spinal cord injury (SCI) during urodynamic studies. found TESCoN can promote storage induce voiding when delivered The objective this study was to determine whether retrain...
Can lower limb motor function be improved after a spinal cord lesion by re-engaging functional activity of the upper limbs? We addressed this issue training forelimbs in conjunction with hindlimbs thoracic hemisection adult rats. The circuitries were more excitable, and behavioural electrophysiological analyses showed hindlimb when engaged simultaneously during treadmill step-training as opposed to only hindlimbs. Neuronal retrograde labelling demonstrated greater number propriospinal...
It is commonly assumed that restoration of locomotion the ultimate goal after spinal cord injury (SCI). However, lower urinary tract (LUT) dysfunction universal among SCI patients and significantly impacts their health quality life. Micturition a neurologically complex behavior depends on intact sensory motor innervation. disrupts both function leads to marked abnormalities in urine storage emptying. Current therapies for LUT focus preventing complications managing symptoms rather than...
Abstract Objective. Electrical spinal cord stimulation (SCS) has emerged as a promising therapy for recovery of motor and autonomic dysfunctions following injury (SCI). Despite the rise in studies using SCS SCI complications, there are no standard guidelines reporting parameters research publications, making it challenging to compare, interpret or reproduce reported effects across experimental studies. Approach. To develop minimum standards pre-clinical clinical research, we gathered an...
This paper presents a fully functionally integrated 1024-channel mixed-mode and mixed-voltage system-on-a-chip (SoC) for epi-retinal neural prostheses. Taking an AC input, power telemetry circuits is capable of generating multiple DC voltages with voltage conversion efficiency 83% at load 100 mW without external diodes or separate circuits, reducing the form factor prosthetic device. A wireless DPSK receiver novel noise reduction scheme supports data rate 2 Mb/s bit-error-rate × 10 <sup...
Abstract Background Epidural stimulation of the spinal cord can be used to enable stepping on a treadmill (electrical enabling motor control, eEmc) after complete mid-thoracic transection in adult rats. Herein we have studied effects eEmc using sub-threshold intensity combined with spontaneous load-bearing proprioception facilitate hindlimb and standing during daily cage activity paralyzed Methods We hypothesized that would greatly increase frequency level activation locomotor circuits...
This paper presents a wirelessly powered, fully integrated system-on-a-chip (SoC) supporting 160-channel stimulation, 16-channel recording, and 48-channel bio-impedance characterization to enable partial motor function recovery through epidural spinal cord electrical stimulation. A wireless transceiver is designed support quasi full-duplex data telemetry at rate of 2 Mb/s. Furthermore, unique in situ scheme based on time-domain analysis implemented derive the Randles cell electrode model...
The inability to control timely bladder emptying is one of the most serious challenges among several functional deficits that occur after a complete spinal cord injury. Having demonstrated electrodes placed epidurally on dorsum can be used in animals and humans recover postural locomotor function paralysis, we hypothesized similar approach could paralysis. Also knowing posture locomotion initiated immediately with specific frequency-dependent stimulation pattern repeated stimulation-training...
We reported previously that both transcutaneous electrical spinal cord stimulation and direct pressure of the plantar surfaces feet can elicit rhythmic involuntary step-like movements in noninjured subjects with their legs a gravity-neutral apparatus. The present experiments investigated convergence voluntary effort activation locomotor uninjured under full body weight support vertical position. For all conditions, leg were analyzed using electromyographic (EMG) recordings optical motion...
Injuries to the spinal cord at cervical level can lead loss of upper limb function. Recent work suggests that combining functional task practice with Transcutaneous electrical stimulation (TCES) increase strength and function in people living chronic injury (cSCI). Participants (n = 5) were randomly assigned to: Group_1 3) receiving one month (ULTP) followed by paired (ULTP+TCES); Group_2 2) ULTP+TCES ULTP. Changes hand (assessed via Graded Redefined Assessment Strength, Sensibility),...
Epidural spinal stimulation has shown effectiveness in recovering the motor function of cord transected rats by modulating neural networks lumbosacral segments [1, 2]. The state-of-the-art neuromodulation implant [3] reports a 4-channel stimulator with wireless data and power links for small animal experiments, yet weighs 6g volume 3cm <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">3</sup> . It is preferable that package comparable size to its...
We present a new perspective on the concept of feed-forward compared to feedback mechanisms for motor control. propose that conceptually all sensory information in real time provided brain and spinal cord can be viewed as phenomenon. also continually adapts broad array ongoing is used adjust probability making timely predictable decisions selected networks will execute given response. One interpretation term historically entails responses with short delays. mechanisms, however, range...
Spinal neuromodulation and activity-based rehabilitation triggers neural network reorganization enhances sensory-motor performances involving the lower limbs, trunk, upper limbs. This study reports acute effects of Transcutaneous Electrical Cord Neuromodulation (SCONE™, SpineX Inc.) on 12 individuals (ages 2 to 50) diagnosed with cerebral palsy (CP) Gross Motor Function Classification Scale (GMFCS) levels ranging from I V. Acute spinal improved postural locomotor abilities in 11 out patients...
Spinal cord stimulation enhanced restoration of motor function following spinal injury (SCI) in unblinded studies. To determine whether training combined with transcutaneous electrical (tSCS), or without systemic serotonergic treatment buspirone (busp), could improve hand individuals severe paralysis SCI, we assessed ten subjects a double-blind, sham-controlled, crossover study. All treatments-busp, tSCS, and the busp plus tSCS-reduced muscle tone spasm frequency. Buspirone did not have any...