A5100647502- Immunotherapy and Immune Responses
- Lung Cancer Treatments and Mutations
- Gastric Cancer Management and Outcomes
- Colorectal Cancer Treatments and Studies
- Cancer Immunotherapy and Biomarkers
- Sarcoma Diagnosis and Treatment
- Lung Cancer Research Studies
- Hepatocellular Carcinoma Treatment and Prognosis
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Immune Cell Function and Interaction
- Cancer Genomics and Diagnostics
- Cancer Treatment and Pharmacology
- Gastrointestinal Tumor Research and Treatment
- vaccines and immunoinformatics approaches
- Renal cell carcinoma treatment
- Pancreatic and Hepatic Oncology Research
- Bladder and Urothelial Cancer Treatments
- Fibroblast Growth Factor Research
- T-cell and B-cell Immunology
- Herpesvirus Infections and Treatments
- HER2/EGFR in Cancer Research
- Vascular Tumors and Angiosarcomas
- Neuroendocrine Tumor Research Advances
- Lung Cancer Diagnosis and Treatment
- CAR-T cell therapy research
Sungkyunkwan University
2015-2025
University of Ulsan
2010-2025
Asan Medical Center
2004-2025
Ulsan College
2010-2025
Ajou University
2010-2025
Samsung (South Korea)
2025
Chonnam National University Hospital
2002-2025
Chonnam National University
2016-2025
Sejong University
2023-2024
International St. Mary's Hospital
2019-2024
Naturally occurring CD4+CD25+ regulatory T cells appear important to prevent activation of autoreactive cells. This article demonstrates that the magnitude a CD8+ cell-mediated immune response an acute viral infection is also subject control by (Treg). Accordingly, if natural Treg were depleted with specific anti-CD25 antibody before HSV, resultant cell immunodominant peptide SSIEFARL was significantly enhanced. shown several in vitro measures reactivity and assays directly determine...
Paralysis of the upper extremities following cervical spinal cord injury (SCI) significantly impairs one's ability to live independently. While regaining hand function or grasping is considered one most desired functions in tetraplegics, limited therapeutic development this direction has been demonstrated date humans with a high severe injury. The underlying hypothesis that after SCI, nonfunctional sensory-motor networks within can be transcutaneously neuromodulated physiological states...
Abstract Background A limited number of studies have characterized genomic properties hepatocellular carcinoma (HCC) patients in response to anti-PD-1 immunotherapy. Methods Herein, we performed comprehensive molecular characterization immediate (D-42 D-1) pre-treatment tumor biopsy specimens from 60 with sorafenib-failed HCC a single-arm prospective phase II trial pembrolizumab. Objective rate was the primary efficacy endpoint. We used whole-exome sequencing, RNA and correlative analysis....
Abstract Macrophages (Mφs) are characterized by remarkable plasticity, an essential component of chronic inflammation. Thus, appropriate and timely transition from proinflammatory (M1) to anti‐inflammatory (M2) Mφs during wound healing is vital promoting resolution acute inflammation enhancing tissue repair. Herein, exosomes derived M2‐Mφs (M2‐Exos), which contain putative key regulators driving Mφ polarization, used as local microenvironmental cues induce reprogramming M1‐Mφs toward for...
Retinol binding protein 4 (RBP4) is a useful biomarker in the diagnosis of type 2 diabetes since its level serum higher insulin-resistant states. Accurate measurement RBP4 levels hampered by conventional immunologic methods, such as enzyme-linked immunosorbent assay (ELISA). In this study, therefore, we have developed an aptamer-based surface plasmon resonance (SPR) biosensor that can be used to sense for samples. A single-stranded DNA (ssDNA) aptamer showed high affinity (Kd = 0.2 +/- 0.03...
Background. Respiratory syncytial virus (RSV) is the leading cause of bronchiolitis and viral death in infants. Despite decades research with traditional or subunit vaccine approaches, there are no approved RSV vaccines. New approaches therefore urgently needed to develop effective Methods. We developed viruslike particles (VLPs) consisting an influenza matrix (M1) protein core RSV-F -G on surface. tested immunogenicity efficacy these VLPs (RSV-F, RSV-G) a mouse model. Results. Intramuscular...
Programmed death-ligand 1 (PD-L1), which is expressed on many cancer cells, interacts with PD1 the surface of T inhibiting cells and blocking antitumor immune response. Expression PD-L1 in gastroenteropancreatic neuroendocrine tumors (GEP-NETs) has not been studied. We investigated impact expression 32 patients metastatic GEP-NET. The was evaluated using an anti-PD-L1 immunohistochemistry (IHC) antibody optimized for staining formalin-fixed paraffin-embedded (FFPE) tissue samples....
Abstract BACKGROUND: Recently, chromosomal rearrangements involving receptor tyrosine kinases (RTKs) have been described in common epithelial malignancies, including nonsmall cell lung cancer (NSCLC), colorectal cancer, and breast cancer. One of these RTKs, c‐ros oncogene 1, kinase (ROS1), has identified as a driver mutation NSCLC, because its inhibition by crizotinib, an anaplastic lymphoma (ALK)/met proto‐oncogene hepatocyte growth factor (MET)/ROS1 inhibitor, led to significant tumor...
Bone is one of the most common sites metastasis from advanced solid tumors. a leading cause pain and increases risk skeletal-related events (SREs) in cancer patients. In addition to affecting quality life, it also medical costs mortality risk. We aimed examine occurrence bone SREs Korean patients using nationwide health database. Using claims data National Health Insurance Service-National Sample Cohort (2002-2013), we extracted diagnosed with any seven major cancers Korea January 2002...
Hutchinson-Gilford progeria syndrome (HGPS) is a rare autosomal dominant genetic disease that caused by silent mutation of the LMNA gene encoding lamins A and C (lamin A/C). The G608G generates more accessible splicing donor site than does WT produces an alternatively spliced product called progerin, which also expressed in normal aged cells. In this study, we determined progerin binds directly to lamin A/C induces profound nuclear aberrations. Given observation, performed random screening...
Given the complexity of managing hepatocellular carcinoma (HCC), a multidisciplinary approach (MDT) is recommended to optimize management HCC patients. However, evidence suggesting that MDT improves patient outcome limited.We performed retrospective cohort study all patients newly-diagnosed with between 2005 and 2013 (n = 6,619). The overall survival (OS) rates who were not managed via compared in entire 6,619), exactly matched 1,396).In cohort, 5-year rate was significantly higher (71.2%...
Abstract Atherosclerosis, the leading cause of death, is a vascular disease chronic inflammation. We recently showed that angiopoietin-like 4 (ANGPTL4) promotes cardiac repair by suppressing pathological Given fundamental contribution inflammation to atherosclerosis, we assessed role ANGPTL4 in development atherosclerosis and determined whether regulates atherosclerotic plaque stability. injected protein twice week into Apoe−/− mice analyzed lesion size, inflammation, In mice, reduced size...
In this report, we demonstrate that herpes simplex virus (HSV) infection of the cornea results in upregulation matrix-degrading metalloproteinase enzyme MMP-9. This was shown to contribute neovascularization process occurs corneal stroma response HSV infection. The likely source MMP-9, at least initially after infection, neutrophils were signaled invade soon Corneal infiltrating express and preventing neutrophil with specific mAb diminished MMP-9 expression as well extent angiogenesis....
The aim of the current study was to determine incidence, clinical presentation, and treatment outcomes "bone-only metastases" in patients with breast cancer analyze impact hormone receptor (HR) human epidermal growth factor 2 (HER2) status on prognosis.Between 1994 2007, 968 metastatic who underwent palliative management at Samsung Medical Center, 565 (57%) relapsed distant metastases. Of 968, 146 (15%) had bone-only metastases during a median follow-up period 75 months. Among metastases,...
Increased mesenchymal-epithelial transition factor gene (c-MET) expression in several human malignancies is related to increased tumor progression and a new potential drug target for types of cancers. In the present study, we investigated incidence c-MET overexpression its prognostic significance patients with colorectal cancer (CRC).We retrospectively reviewed data from 255 stage IV CRC who had results immunohistochemical test at Samsung Medical Center. We explored relationships between...
We retrospectively reviewed outcomes of treatment with pazopanib, an oral multi-tyrosine kinase angiogenesis inhibitor, in patients advanced soft tissue sarcoma, a rare and heterogeneous tumor group limited options.Between 2009 2013, 43 metastatic sarcoma received pazopanib as salvage chemotherapy after one or more cytotoxic regimens. Response rate, progression-free survival, overall survival were analyzed according to histological subtype, Eastern Cooperative Oncology Group performance...
Abstract Background. KIT has been suggested to be a potential therapeutic target for malignant melanoma. We evaluated the antitumor activity and safety of inhibitor nilotinib in metastatic melanoma patients harboring gene mutations or amplifications. Methods. conducted phase II multicenter trial with Patients received 400 mg oral twice daily. The primary endpoint was response rate, if seven more responders were observed from cumulative 36 patients, would considered worthy further testing...