A5030897866- Palliative Care and End-of-Life Issues
- Patient Dignity and Privacy
- Neuroendocrine Tumor Research Advances
- Childhood Cancer Survivors' Quality of Life
- Ethics in medical practice
- HER2/EGFR in Cancer Research
- Cancer survivorship and care
- Hematopoietic Stem Cell Transplantation
- Grief, Bereavement, and Mental Health
- Lung Cancer Research Studies
- Cancer Treatment and Pharmacology
- Multiple Myeloma Research and Treatments
- Neuroblastoma Research and Treatments
- Chronic Lymphocytic Leukemia Research
- Chronic Myeloid Leukemia Treatments
- Healthcare Education and Workforce Issues
- Lung Cancer Treatments and Mutations
- Gastric Cancer Management and Outcomes
- Peptidase Inhibition and Analysis
- Retinoids in leukemia and cellular processes
- Pituitary Gland Disorders and Treatments
- Health and Wellbeing Research
- Innovations in Medical Education
- Patient-Provider Communication in Healthcare
- Testicular diseases and treatments
Ewha Womans University
2011-2020
Dongguk University
2017
Dongguk University Ilsan Hospital
2017
Ewha Womans University Medical Center
1995-2015
Seoul National University
2005-2013
Seoul National University Hospital
2013
Yonsei University
2013
Keimyung University
2013
Dongwha Pharm (South Korea)
2005
Baewha Women's University
1995-2005
A phase I dose-escalation clinical trial of peritumoral injections interleukin 12 (IL-12)-transduced autologous fibroblasts was performed in patients with disseminated cancer for whom effective treatment does not exist. The goals this study were to assess the safety and toxicities as well efficacy, ancillarily immunomodulatory effects, IL-12 gene transfer. Primary dermal cultured from transduced retroviral vector carrying human genes (p35 p40) neomycin phosphotransferase (TFG-hIL-12-Neo)....
<h3>Background:</h3> Whereas most studies have focused on euthanasia and physician-assisted suicide, few dealt comprehensively with other critical interventions administered at the end of life. We surveyed cancer patients, family caregivers, oncologists members general public to determine their attitudes toward such interventions. <h3>Methods:</h3> a questionnaire four groups about five end-of-life — withdrawal futile life-sustaining treatment, active pain control, withholding measures,...
Abstract Background. KIT has been suggested to be a potential therapeutic target for malignant melanoma. We evaluated the antitumor activity and safety of inhibitor nilotinib in metastatic melanoma patients harboring gene mutations or amplifications. Methods. conducted phase II multicenter trial with Patients received 400 mg oral twice daily. The primary endpoint was response rate, if seven more responders were observed from cumulative 36 patients, would considered worthy further testing...
To examine the current practices relating to do-not-resuscitate (DNR) orders for terminal patients with cancer at teaching hospitals in Korea.The records of 387 deaths from January 1 December 31, 2005 four centers were identified and reviewed assess DNR delineation. Basic demographics, circumstances surrounding establishment directive, percentage populations, time interval between consent death evaluated.An order was obtained 296 (76%) a total patients. All consents made physician family,...
We aimed to evaluate the potential benefits of Leadership and Coaching for Health (LEACH) program on physical activity (PA), dietary habits, distress management in cancer survivors.We randomly assigned 248 survivors with an allocation ratio two-to-one LEACH (LP) group, coached by long-term survivors, or usual care (UC) group. At baseline, 3, 6, 12 months, we used PA scores, intake vegetables fruits (VF), Post Traumatic Growth Inventory (PTGI) as primary outcomes and, secondary outcomes, Ten...
A 60-year-old man presented with cough, sputum, and dyspnea. He had a history of acute myeloid leukemia hematopoietic stem cell transplantation chronic renal failure. Chest CT scans showed miliary nodules patchy consolidations. Histological examination revealed numerous fibrin balls within the alveoli thickening alveolar septum, both which are typical pathological features fibrinous organizing pneumonia (AFOP). We report first case AFOP following allogeneic transplantation.
Purpose We tried to evaluate the association of self-leadership, effective health behaviors, and posttraumatic growth with health-related quality life (HRQOL). Methods recruited survivors cancer from seven hospitals in Korea between 2011 2012. The patients completed Seven Habits Profile (7HP) leadership competency, 10 rules for highly behavior behavior, Posttraumatic Growth Inventory (PTGI) growth, Short Form 36 (SF-36) HRQOL, Hospital Anxiety Depression Scale (HADS) anxiety depression....
Abstract Integrated early palliative care ( EPC ) improves quality of life and reduces psychological distress in adult patients with cancer caregivers, but attitudes toward have been poorly studied. We aimed to investigate a nationwide survey caregivers. From July October 2016, we administered questionnaires examining n = 1001) their families 1006) from 12 Korean hospitals. When an individual considered unnecessary, the reasons were collected analyzed. Factors associated perception examined....
Accurate awareness of the prognosis is an important factor in treatment decision patients with advanced cancer; however, prognostic disclosure still subject to debate because it can reduce patient's satisfaction and increase depression.The purpose this study assess whether patients' associated decreased quality life (QoL) or increased depressive mood cancer.In cohort study, 386 cancer were recruited across 3 periods from December 2016 August 2018. The outcome was a change QoL depression...
Aims and Background The HER2 gene encodes a 185-kd transmembrane glycoprotein receptor (p185 ) that has partial homology with the epidermal growth factor shares intrinsic tyrosine kinase activity. phosphatase tensin homolog mutated on chromosome ten (PTEN) product is protein participates in modulating phosphoinositide 3-kinase pathway which antagonizing activity to kinase. authors investigated correlation between clinicopathologic variables including survival overexpression of p185 loss PTEN...
Imatinib mesylate is the first molecule of targeted therapy in chronic myelogenous leukaemia inhibiting constitutively activated BCR-ABL kinase. There are no long-term follow-up studies large sample sizes to assess toxicity use imatinib over 10 years. Several cases hepatotoxicity, including fatal liver failure, have been associated with mesylate. We report here on a patient who experienced immediate dominant cholestatic damage and mild hepatocyte during therapy. This differs from most...
Purpose Heptaplatin (Sunpla) is a cisplatin derivative. A phase IIb trial using heptaplatin resulted in 34% response rate with mild nephrotoxicity. We conducted randomized III of plus 5-FU compared patients advanced gastric cancer. Materials and Methods One hundred seventy-four (heptaplatin, n=88; cisplatin, n=86) from 13 centers were enrolled. The eligibility criteria as follows: pathologically-proven adenocarcinoma, chemonaive patients, or who had received only single adjuvant...
The pyrimidine antimetabolite 5-fluorouracil (5-FU) is a chemotherapeutic agent used widely for various tumors. Common side effects of 5-FU are related to its on the bone marrow and gastrointestinal epithelium. Neurotoxicity caused by uncommon, although acute delayed forms have been reported. Wernicke's encephalopathy an acute, neuropsychiatric syndrome resulting from thiamine deficiency, has significant morbidity mortality. Central nervous system neurotoxicity such as following chemotherapy...
Positive attitudes for end-of-life (EOL) care along with adequate education are key factors the provision of quality EOL care. This national study was conducted to identify that influence toward on medical students.An anonymous survey designed and administered fourth-year students at all 41 schools in Korea. Topics related were assessed classroom teaching, bedside feedback experiences during clinical clerkships. Seven questions self-rated affecting analyzed care.With a response rate 49.2%,...
Background: To determine whether the Health Partner Program is effective in training long-term cancer survivors to be health coaches. Materials and Methods: We randomly assigned who were selected through a rigorous screening process either or waiting-list control group. The program consisted of 8 weeks management, leadership, coaching. At baseline, 8, 16 weeks, we measured primary outcomes using Seven Habit Profile (SHP), Korean Leadership Coaching Competency Inventory (KCCI), Ed Diner's...
A combination of serotonin receptor (5-hydroxytryptamine type 3) antagonists, NK-1 antagonist, and steroid improves the complete response (CR) chemotherapy-induced nausea vomiting (CINV) in cancer patients. Ramosetron's efficacy this triple regimen has not been investigated. This prospective, multicenter, single-blind, randomized, phase III study compares a ramosetron, aprepitant, dexamethasone (RAD) with ondansetron, (OAD) to prove noninferiority RAD controlling highly emetogenic...
Background. Although terminal cancer is a widely used term, its meaning varies, which may lead to different attitudes toward end-of-life issues. The study was conducted investigate differences in the understanding of and determine relationship between this Methods. A questionnaire survey performed 2008 2009. total 1242 patients, 1289 family caregivers, 303 oncologists from 17 hospitals, 1006 participants general population responded. Results. “6-month life expectancy” most common (45.6%),...
CD4+ T cells are a critical component of the adaptive immune response. While mechanisms controlling differentiation Th1, Th17, and regulatory cell subsets from naïve well described, factors that induce Th2 still largely unknown.The effects treatment with exogenous H2O2 on STAT-6 phosphorylation activation in were examined by immunoblotting, immunofluorescence gel shift assay. Anti-CD3 antibody methyl-β-cyclodextrin utilized to lipid raft assembly investigate involvement rafts,...
Purpose We wanted to analyze the use of nutrition support for terminal cancer patients, effect discussing withdrawal and do-not-resuscitate (DNR) consent on intravenous during patient's last week life at time death. Materials Methods The study involved 362 patients with from four teaching hospitals, they all died between January 1 2003 December 31 2005. basic demographic data, death, discussion DNR were evaluated. Results In before received artificial such as total parenteral (31%), albumin...
Purpose This study was designed to evaluate the communication gap between Korean medical oncologists and cancer patients on complementary alternative medicine (CAM). Materials Methods Cross sectional studies utilized responses of 59 211 patients. To understand gap, perceived reasons nondisclosure CAM use, reactions physicians disclosure, expectations for were analyzed. Data compared with use chi-squared test. Results Both in accord that would privde a feeling hope. The believed more often...
The aims of this study were to investigate the correlation between topoisomerase II alpha (TOP2A), microtubule-associated protein-tau (MAP-tau) and other prognostic factors in breast cancer evaluate predictive value TOP2A MAP-tau patients who received anthracycline taxane-containing adjuvant chemotherapy.Seventy with axillary lymph node positive underwent curative surgery January 2000 December 2005 evaluated retrospectively. levels protein expression assessed using immunohistochemistry.Among...