A5052568687- Advanced Sensor and Energy Harvesting Materials
- Electrochemical sensors and biosensors
- Analytical Chemistry and Sensors
- Microfluidic and Capillary Electrophoresis Applications
- 3D Printing in Biomedical Research
- Conducting polymers and applications
- Advanced Chemical Sensor Technologies
- Tactile and Sensory Interactions
- Biosensors and Analytical Detection
- Electrowetting and Microfluidic Technologies
- Advanced Photocatalysis Techniques
- Gas Sensing Nanomaterials and Sensors
- Advancements in Transdermal Drug Delivery
- Ammonia Synthesis and Nitrogen Reduction
- Advancements in Battery Materials
- Metabolomics and Mass Spectrometry Studies
- Neuroscience and Neural Engineering
- Perovskite Materials and Applications
- Advanced battery technologies research
- Hybrid Renewable Energy Systems
- Polydiacetylene-based materials and applications
- Advanced biosensing and bioanalysis techniques
- Mechanical and Optical Resonators
- Hydrogen Storage and Materials
- EEG and Brain-Computer Interfaces
BioElectronics (United States)
2019-2025
University of California, Los Angeles
2019-2025
Los Angeles City College
2019-2020
University of California System
2019
Zhejiang University
2015-2017
Wearable technologies for personalized monitoring require sensors that track biomarkers often present at low levels. Cortisol—a key stress biomarker—is in sweat nanomolar concentrations. Previous wearable sensing systems are limited to analytes the micromolar-millimolar ranges. To overcome this and other limitations, we developed a flexible field-effect transistor (FET) biosensor array exploits previously unreported cortisol aptamer coupled nanometer-thin-film In2O3 FETs. Cortisol levels...
Therapeutic drug monitoring is essential for dosing pharmaceuticals with narrow therapeutic windows. Nevertheless, standard methods are imprecise and involve invasive/resource-intensive procedures long turnaround times. Overcoming these limitations, we present a microneedle-based electrochemical aptamer biosensing patch (μNEAB-patch) that minimally invasively probes the interstitial fluid (ISF) renders correlated, continuous, real-time measurements of circulating drugs' pharmacokinetics. The...
Abstract Real‐time monitoring of human health can be significantly improved by designing novel electronic skin (E‐skin) platforms that mimic the characteristics and sensitivity skin. A high‐quality E‐skin platform simultaneously monitor multiple physiological metabolic biomarkers without introducing discomfort or irritation is an unmet medical need. Conventional E‐skins are either monofunctional made from elastomeric films do not include key synergistic features natural skin, such as...
Abstract Active biofluid management is central to the realization of wearable bioanalytical platforms that are poised autonomously provide frequent, real-time, and accurate measures biomarkers in epidermally-retrievable biofluids (e.g., sweat). Accordingly, here, a programmable epidermal microfluidic valving system devised, which capable sampling, routing, compartmentalization for biomarker analysis. At its core, network individually-addressable microheater-controlled thermo-responsive...
We devised a strategy for high-fidelity, wearable biomarker data acquisition and sensor integration with consumer electronics.
Significance To achieve the mission of personalized medicine, centering on delivering right drug to patient at dose, therapeutic monitoring solutions are necessary. By devising a surface engineering strategy, we created voltammetric sensing interface, featuring an “undistorted potential window,” within which target electroactive drug’s response is dominant and interference eliminated, rendering reliable quantification in noninvasively retrievable biofluids (sweat saliva). Leveraging this...
Recent advances in microelectronics, microfluidics, and electrochemical sensing platforms have enabled the development of an emerging class fully integrated personal health monitoring devices that exploit sweat to noninvasively access biomarker information. Despite such advances, effective sampling remains a significant challenge for reliable analysis, with many existing methods requiring active stimulation (e.g., iontophoresis, exercise, heat). Natural perspiration offers suitable...
Porous carbon can be tailored to great effect for electrochemical energy storage. In this study, we propose a novel structured spherical with macrohollow core and microporous shell derived from sustainable biomass, amylose, by multistep pyrolysis route without chemical etching. This hierarchically porous shows particle distribution of 2-10 μm surface area 672 m2 g-1. The structure is an effective host sulfur lithium-sulfur battery cathodes, which reduces the dissolution polysulfides in...
Abstract Wearable electroenzymatic sensors enable monitoring of clinically informative biomolecules in epidermally retrievable biofluids. Conventional wearable enzymatic utilize Prussian Blue (a redox mediator) to achieve selectivity against electroactive interferents. However, the use presents fundamental challenges including: 1) susceptibility sensor response dynamic concentration variation ionic species and 2) poor operational stability due degradation its framework. As an alternative...
Microchannels created in poly-2-hydroxyethyl methacrylate (poly(HEMA)) hydrogels have the potential to prevent dry-eye disease by facilitating tear exchange. Biosensors are further demonstrated for wearable biosensing applications.
The large-scale deployment of wearable bioanalytical devices for general population longitudinal monitoring necessitates rapid and high throughput manufacturing-amenable fabrication schemes that render disposable, low-cost, mechanically flexible microfluidic modules capable performing a variety operations within compact footprint. spatial constraints previously reported (with confined to 2D), their lack biofluid manipulation capability, the complex low-throughput nature process inherently...
Emerging electronic skins (E-Skins) offer continuous, real-time electrophysiological monitoring. However, daily mechanical scratches compromise their functionality, underscoring urgent need for self-healing E-Skins resistant to damage. Current materials have slow recovery times, impeding reliable signal measurement. The inability heal within 1 minute is a major barrier commercialization. A composition achieving 80% has not yet been reported. Here, we present rapidly E-Skin tailored...
Mimicking metabolic pathways on electrodes enables in vivo metabolite monitoring for decoding metabolism. Conventional sensors cannot accommodate underlying complex reactions involving multiple enzymes and cofactors, addressing only a fraction of enzymatic few metabolites. We devised single-wall-carbon-nanotube-electrode architecture supporting tandem pathway–like linkable to oxidoreductase-based electrochemical analysis, making vast majority metabolites detectable vivo. This robustly...
Wearable drug monitoring targeting epidermally retrievable biofluids (e.g., sweat) can enable a variety of applications, including compliance/abuse and personalized therapeutic dosing. In that regard, voltammetry-based approaches are suitable because they uniquely leverage the electroactive nature target molecules for quantification, eliminating reliance on availability recognition elements. However, to adapt such envisioned application, three main challenges must be addressed: (1)...
The awareness of individuals’ biological status is critical for creating interactive and adaptive environments that can actively assist the users to achieve optimal outcomes. Accordingly, specialized human–machine interfaces—equipped with bioperception interpretation capabilities—are required. To this end, we devised a multimodal cryptographic bio-human–machine interface (CB-HMI), which seamlessly translates user’s touch-based entries into encrypted biochemical, biophysical, biometric...
This work presents a wearable electrofluidic actuation system, which exploits the alternating current electrothermal (ACET) effects to engineer biofluid flow profiles on body.
Abstract Lithium is a drug widely employed for the treatment of bipolar disorder owing to its high efficacy in mood management and suicide prevention. However, this often undermined by misdosing nonadherence, diligent monitoring required during treatment. Standard lithium involves invasive blood collections laboratory analysis with low time granularity. Recent advances sensor technology have enabled development personalized drug‐monitoring devices that analyze biomarker information...
Voltammetry-based sensing systems are suitable for wearable monitoring of electroactive biomarkers in epidermally-retrievable biofluids (e.g., sweat), as they can directly transduce the redox features targets into electrical signals, delivering a sample-to-answer solution. To render reliable voltammetric readouts, fundamental challenge biofluid-induced fouling (causing rapid and irreversible signal degradation) must be addressed-an issue which has been overlooked previously reported sensor...
Programmable microfluidic valving enables controlled routing and compartmentalized manipulation of fluid within networks channels-capabilities which can be harnessed to implement an automated, massively parallelized, diverse set bioanalytical operations in large-scale microfluidics (lab-on-a-chip) wearable (labon-the-body) applications. Stimuli-responsive hydrogels are suitable base materials construct programmable interfaces: once embedded a channel, their volumetric shrinkage/expansion (in...
Ion-Selective Biosensors In article 2202141, Sam Emaminejad and co-workers develop a touch-based noninvasive system to monitor lithium-based pharmacotherapy. It utilizes thin organohydrogel lithium ion-selective electrode (TOH-ISE) that has dehydration-resistant properties, minimizing signal drift, allowing for sweat collection. The is successfully validated on patient under therapy, demonstrating its potential adherence monitoring broad pharmacotherapy management.
In article number 1908507, Sam Emaminejad and co-workers report the fundamental challenges of conventional Prussian Blue-based wearable enzymatic sensors, which need to be resolved for their reliable operation in complex biofluids. Accordingly, they devise an alternative mediator-free electroenzymatic sensing methodology, where experimental results indicate high degrees sensitivity, selectivity, stability developed sensors wireless biofluid analysis.
To realize personalized medicine, the right drug needs to be delivered patient at dose. However, it is extremely challenging dose drugs with narrow therapeutic windows (e.g., antibiotics). For these drugs, due small difference between ineffective and toxic concentration levels, prescribed dosage may result in a circulating outside window, leading toxicity ( e.g. , kidney injury) and/or pharmacotherapy. prevent such adverse events, patients under medications are committed monitoring (TDM),...
Dehydrogenase-based electroenzymatic sensors enable monitoring of a wide panel clinically important biomarkers (e.g., ketones) in sample-to-answer manner.To adapt these for non-invasive wearable biomarker monitoring, key challenges remain terms achieving low detection limit (due to the analyte dilution non-invasively retrievable biofluids such as sweat) and mitigating confounding effect electroactive interferents.To overcome challenges, we present an integrated bioanalytical microfluidic...