A5059257116- Advanced Sensor and Energy Harvesting Materials
- Tactile and Sensory Interactions
- Electrochemical sensors and biosensors
- Analytical Chemistry and Sensors
- Electrowetting and Microfluidic Technologies
- Conducting polymers and applications
- Microfluidic and Capillary Electrophoresis Applications
- 3D Printing in Biomedical Research
- Interactive and Immersive Displays
- Nanomaterials and Printing Technologies
- Microfluidic and Bio-sensing Technologies
- Scheduling and Optimization Algorithms
- Biosensors and Analytical Detection
- Modular Robots and Swarm Intelligence
- Advanced Manufacturing and Logistics Optimization
- Organic Electronics and Photovoltaics
- Nanowire Synthesis and Applications
- SARS-CoV-2 detection and testing
- Surface Modification and Superhydrophobicity
- Innovative Microfluidic and Catalytic Techniques Innovation
- Mechanical and Optical Resonators
- Iterative Learning Control Systems
- Neuroscience and Neural Engineering
- Digital Accessibility for Disabilities
- User Authentication and Security Systems
University of Hong Kong
2022-2024
Chinese University of Hong Kong
2023-2024
Nano and Advanced Materials Institute
2024
BioElectronics (United States)
2019-2022
University of California, Los Angeles
2019-2022
Terasaki Foundation
2021
University of California System
2019-2020
Los Angeles City College
2019-2020
Guangdong University of Technology
2005
Wearable technologies for personalized monitoring require sensors that track biomarkers often present at low levels. Cortisol—a key stress biomarker—is in sweat nanomolar concentrations. Previous wearable sensing systems are limited to analytes the micromolar-millimolar ranges. To overcome this and other limitations, we developed a flexible field-effect transistor (FET) biosensor array exploits previously unreported cortisol aptamer coupled nanometer-thin-film In2O3 FETs. Cortisol levels...
Embedding microfluidic architectures with microneedles enables fluid management capabilities that present new degrees of freedom for transdermal drug delivery. To this end, fabrication schemes can simultaneously create and integrate complex millimeter/centimeter-long structures micrometer-scale microneedle features are necessary. Accordingly, three-dimensional (3D) printing techniques suitable candidates because they allow the rapid realization customizable yet intricate features. However,...
Abstract Active biofluid management is central to the realization of wearable bioanalytical platforms that are poised autonomously provide frequent, real-time, and accurate measures biomarkers in epidermally-retrievable biofluids (e.g., sweat). Accordingly, here, a programmable epidermal microfluidic valving system devised, which capable sampling, routing, compartmentalization for biomarker analysis. At its core, network individually-addressable microheater-controlled thermo-responsive...
We devised a strategy for high-fidelity, wearable biomarker data acquisition and sensor integration with consumer electronics.
Significance To achieve the mission of personalized medicine, centering on delivering right drug to patient at dose, therapeutic monitoring solutions are necessary. By devising a surface engineering strategy, we created voltammetric sensing interface, featuring an “undistorted potential window,” within which target electroactive drug’s response is dominant and interference eliminated, rendering reliable quantification in noninvasively retrievable biofluids (sweat saliva). Leveraging this...
A ferrobotic system is devised to implement diverse, efficient, and automated microfluidic logistics.
Recent advances in microelectronics, microfluidics, and electrochemical sensing platforms have enabled the development of an emerging class fully integrated personal health monitoring devices that exploit sweat to noninvasively access biomarker information. Despite such advances, effective sampling remains a significant challenge for reliable analysis, with many existing methods requiring active stimulation (e.g., iontophoresis, exercise, heat). Natural perspiration offers suitable...
Abstract The use of conducting polymers such as poly(3,4‐ethylenedioxythiophene) polystyrene sulfonate (PEDOT:PSS) for the development soft organic bioelectronic devices, electrochemical transistors (OECTs), is rapidly increasing. However, directly manipulating polymer thin films on substrates remains challenging, which hinders conformable devices. A facile transfer‐printing from conventional rigid to flexible offers an alternative solution. In this work, it reported that PEDOT:PSS glass...
Engineering heterogeneous hydrogels with distinct phases at various lengths, which resemble biological tissues high complexity, remains challenging by existing fabricating techniques that require complicated procedures and are often only applicable bulk scales. Here, inspired ubiquitous phase separation phenomena in biology, we present a one-step fabrication method based on aqueous to construct two-aqueous-phase gels comprise multiple physicochemical properties. The fabricated this approach...
Wearable piezoresistive sensors are being developed as electronic skins (E-skin) for broad applications in human physiological monitoring and soft robotics. Tactile with sufficient sensitivities, durability, large dynamic ranges required to replicate this critical component of the somatosensory system. Multiple micro/nanostructures, materials, sensing modalities have been reported address need. However, a trade-off arises between device performance complexity. Inspired by microstructure...
Robotics for scientific research are evolving from grasping macro-scale solid materials to directly actuating micro-scale liquid samples. However, current actuation mechanisms often restrict operable types or compromise the activity of biochemical samples by introducing interfering mediums. Here, we propose a robotic handling system enabled novel droplet mechanism, termed electret-induced polarization on (EPD). EPD enables all-liquid in principle and experimentally exhibits generality...
Abstract Wearable electroenzymatic sensors enable monitoring of clinically informative biomolecules in epidermally retrievable biofluids. Conventional wearable enzymatic utilize Prussian Blue (a redox mediator) to achieve selectivity against electroactive interferents. However, the use presents fundamental challenges including: 1) susceptibility sensor response dynamic concentration variation ionic species and 2) poor operational stability due degradation its framework. As an alternative...
The large-scale deployment of wearable bioanalytical devices for general population longitudinal monitoring necessitates rapid and high throughput manufacturing-amenable fabrication schemes that render disposable, low-cost, mechanically flexible microfluidic modules capable performing a variety operations within compact footprint. spatial constraints previously reported (with confined to 2D), their lack biofluid manipulation capability, the complex low-throughput nature process inherently...
Wearable drug monitoring targeting epidermally retrievable biofluids (e.g., sweat) can enable a variety of applications, including compliance/abuse and personalized therapeutic dosing. In that regard, voltammetry-based approaches are suitable because they uniquely leverage the electroactive nature target molecules for quantification, eliminating reliance on availability recognition elements. However, to adapt such envisioned application, three main challenges must be addressed: (1)...
Hierarchical compartmentalization responding to changes in intracellular and extracellular environments is ubiquitous living eukaryotic cells but remains a formidable task synthetic systems. Here we report two-level approach based on thermo-responsive aqueous two-phase system (TR-ATPS) comprising poly(N-isopropylacrylamide) (PNIPAM) dextran (DEX). Liquid membraneless compartments enriched PNIPAM are phase-separated from the continuous DEX solution via liquid-liquid phase separation at 25 °C...
We present a hybrid-flex wearable system to autonomously analyze sweat—induced at programmable secretion rates—for diurnal biomarker data acquisition.
The awareness of individuals’ biological status is critical for creating interactive and adaptive environments that can actively assist the users to achieve optimal outcomes. Accordingly, specialized human–machine interfaces—equipped with bioperception interpretation capabilities—are required. To this end, we devised a multimodal cryptographic bio-human–machine interface (CB-HMI), which seamlessly translates user’s touch-based entries into encrypted biochemical, biophysical, biometric...
This work presents a wearable electrofluidic actuation system, which exploits the alternating current electrothermal (ACET) effects to engineer biofluid flow profiles on body.
Advancements in wearable bioanalytical microsystems have enabled diurnal and (semi)continuous monitoring of physiologically-relevant indices that are accessible through probing sweat. To deliver an undistorted physiologically-meaningful interpretation these readings, tracking the sweat secretion rate is essential, because it allows for calibrating biomarker readings against variations inferring body's hydration/electrolyte homeostasis status. realize autonomous solution with intrinsically...
Patterning of conducting polymer poly(3,4)ethylenedioxythiophene doped with polystyrene sulfonate (PEDOT:PSS) thin films directly on hydrophobic soft substrates is challenging. Shiming Zhang, Ali Khademhosseini, and co-workers, in article number 1906016, report that hydrogels are capable transfer-printing patterned PEDOT:PSS from glass onto various substrates. Using this method, skin-attachable organic electrochemical transistors developed for personalized biosensing applications.
Programmable microfluidic valving enables controlled routing and compartmentalized manipulation of fluid within networks channels-capabilities which can be harnessed to implement an automated, massively parallelized, diverse set bioanalytical operations in large-scale microfluidics (lab-on-a-chip) wearable (labon-the-body) applications. Stimuli-responsive hydrogels are suitable base materials construct programmable interfaces: once embedded a channel, their volumetric shrinkage/expansion (in...
The integration of electrochemical sensors in wearable consumer electronics enables monitoring the health status individuals at molecular levels across general population, and thus can play a critical role transforming personalized precision medicine. Previously, we devised seamless strategy to interface disposable mediator-free enzymatic sensors-constructed on anisotropic conductive films (ACFs)-with electronics. To illustrate generalizability our approach, here, leverage ACF electrodes as...