A5046359891- Functional Brain Connectivity Studies
- Tryptophan and brain disorders
- Gut microbiota and health
- Diet and metabolism studies
- Mental Health Research Topics
- Bipolar Disorder and Treatment
- Advanced Neuroimaging Techniques and Applications
- Plasmonic and Surface Plasmon Research
- Neural dynamics and brain function
- Genetic Associations and Epidemiology
- Transcranial Magnetic Stimulation Studies
- Stress Responses and Cortisol
- Photonic Crystals and Applications
- Treatment of Major Depression
- Electroconvulsive Therapy Studies
- Metamaterials and Metasurfaces Applications
- Advanced MRI Techniques and Applications
- Anxiety, Depression, Psychometrics, Treatment, Cognitive Processes
- Maternal Mental Health During Pregnancy and Postpartum
- Neural and Behavioral Psychology Studies
- Suicide and Self-Harm Studies
- Graphene research and applications
- Genetic Syndromes and Imprinting
- Psychosomatic Disorders and Their Treatments
- Fluid Dynamics and Mixing
First Hospital of Shanxi Medical University
2018-2025
Shanxi Medical University
2018-2025
Nankai University
2012-2013
Tianjin University
2013
Abstract Inflammatory depression is a treatment-resistant subtype of depression. A causal role the gut microbiota as source low-grade inflammation remains unclear. Here, part an observational trial, we first analyze composition in stool, inflammatory factors and short-chain fatty acids (SCFAs) plasma, permeability markers intestinal mucosa patients with (ChiCTR1900025175). Gut exhibits higher Bacteroides lower Clostridium , increase SCFA-producing species abnormal butanoate metabolism. We...
The gut-brain axis is implicated in depression development, yet its underlying mechanism remains unclear. We observed depleted gut bacterial species, including Bifidobacterium longum and Roseburia intestinalis, the neurotransmitter homovanillic acid (HVA) individuals with mouse models. Although R. intestinalis does not directly produce HVA, it enhances B. abundance, leading to HVA generation. This highlights a synergistic interaction among microbiota regulating intestinal production....
Highly tunable optical antennas in teraherz range based on graphene ring structures are proposed, which employ plasmons instead of traditional metallic plasmons. The plasmon resonances the perfect (PGR) can be understood with edge ribbons. While nonconcentric ring, multipolar modes appear and anti-symmetric mode splits due to symmetry breaking. Furthermore, symmetric a concentrate electromagnetic field an enhancement factor as large 103 terahertz waveband, is almost 20 times larger than gold...
Gut microbiota and its metabolite bile acids may play a significant role in the occurrence development of major depressive disorder (MDD). Therefore, this study analyzes gut acids, as well their correlation patients.Thirty-one patients with MDD 29 healthy controls (HCs) were enrolled study. We collected both blood feces. Plasma acid content was determined by liquid chromatography-mass spectrometry detected 16SrRNA gene sequencing subsequently analyzed. also analyzed between different...
The microbiota-gut-brain axis, especially the inflammatory pathway, may play a critical role in pathogenesis of cognitive impairment major depressive disorder (MDD). However, studies on microbiota-inflammatory-cognitive function axis MDD are lacking. aim present study was to analyze gut microbiota composition and explore correlation between factors, patients.
Aerobic exercise exerts a significant impact on the gut microbiota imbalance and atherosclerosis induced by high-fat diet. However, whether fecal transplantation, based aerobic exercise, can improve progression remains unexplored. In this study, we utilized male C57 mice to establish models of atherosclerosis, followed transplantation(Fig 1a). Firstly, analyzed body weight, somatotype, adipocyte area, aortic HE images model mice. Our findings revealed that diet -induced exhibited elevated...
Abstract Non-suicidal self-injury (NSSI) in adolescent depression is a prevalent and clinically significant behavior linked to dysregulated peripheral inflammation corticostriatal circuitry dysfunction. However, the neuroimmune mechanisms bridging these systems remain poorly understood. Here, we combined cytokine profiling with static/dynamic functional connectivity (sFC/dFC) analysis investigate potential influence of inflammaton on circuit related NSSI. A set blood inflammatory markers...
Surface plasmon modes at terahertz-infrared waveband in subwavelength graphene wedge and groove waveguides are investigated, which can be categorized into perfect electric conductor magnetic symmetric with different propagation characteristics. The electromagnetic near-fields localized strongly regions for these two kinds of modes. Moreover, interpreted by the folded ribbon brim width Fermi energy influence dispersion distances modes, used tuning efficiently.
Studies have confirmed that the thalamus and primary somatosensory cortex (SI) are associated with cognitive function. These two brain regions closely related in structure The interactions between SI of crucial significance for process. Patients major depressive disorder (MDD) significant impairment. Based on these observations, we used resting-state functional magnetic resonance imaging (rs-fMRI) to investigate whether there is an abnormality SI-thalamic connection MDD. Furthermore,...
Purpose: The diversity and composition of the oral gut microbiota depressed rats were analyzed to explore microbiological etiology major depressive disorder (MDD). Methods: rat model was established by inducing chronic unpredictable mild stress (CUMS). After establishment model, body weight measurements behavioral tests conducted. using 16SrRNA sequencing. Results: There significant differences in alpha beta CUMS control groups. top three most abundant genera Rothia , Psychrobacter...
Abstract Background This study aimed to explore the gut microbiota and inflammatory factor characteristics in major depressive disorder (MDD) patients with anorexia analyze correlation between factors, anorexia, HAMD scores. Methods 46 MDD healthy controls (HC) were included study. The divided into two groups according whether they had anorexia:20 without (MDA0 group) 26 (MDA1 group). We used Hamilton Depression Scale-24 (HAMD-24) evaluate depression status of all participants 16 S ribosomal...
The current study aimed to explore the functional changes of amygdala in patients with euthymic Bipolar Disorder (BD) using resting state fMRI (rs-fMRI). Twenty-one bipolar disorder and twenty-eight healthy controls participated this study, two BD three were excluded due excessive head motion. Patients euthymia (38.79±12.03) show higher fALFF (fractional Amplitude low-frequency fluctuation) value (t = 2.076, P 0.044) lower connectivity between supplementary motor area (p<0.01, GRF corrected)...
Background: Major depressive disorder (MDD) is a leading psychiatric that has lack of biomarkers for diagnosis. Purpose: The objective this study was to examine the structural and functional change in precuneus within first-episode drug naive patients with MDD. Methods: Thirty-two first episode drug-naive MDD thirty healthy controls (HCs) were recruited study; MRI fMRI data collected using 3.0 T Trio Siemens System. All interviewed HAMD-17. Results: difference between gray matter volume two...
ABSTRACT Background Bipolar disorder (BD) is a complex mental condition of which the mechanism onset remains unclear. Mendelian randomization (MR) allows evaluation causal effects biomarkers by minimizing risks reverse causation and confounding factors. In this study, MR was used to assess relationships between neurodevelopment‐related proteins BD, thereby providing potential evidence for neurodevelopmental hypothesis disorder. Methods Leveraging data from large‐scale genome‐wide association...
Gut microbiota and childhood maltreatment are closely related to depressive symptoms. This study aimed analyze the characteristics of gut in major disorder (MDD) patients with experience explore correlation between microbiota, maltreatment, A total 37 healthy controls (HCs) 53 MDD were enrolled, including 18 without 35 experience. The Hamilton's Depression Scale (HAMD-24) Childhood Trauma Questionnaire-Short Form (CTQ-SF) used evaluate their symptoms experience, respectively. composition was...