A5010327256- Schizophrenia research and treatment
- Tryptophan and brain disorders
- Metal-Organic Frameworks: Synthesis and Applications
- Zebrafish Biomedical Research Applications
- Acute Myeloid Leukemia Research
- Epigenetics and DNA Methylation
- Pancreatitis Pathology and Treatment
- Covalent Organic Framework Applications
- Inorganic Fluorides and Related Compounds
- Bipolar Disorder and Treatment
- Gut microbiota and health
- Stress Responses and Cortisol
- Diet and metabolism studies
- Pluripotent Stem Cells Research
- Dermatology and Skin Diseases
- Membrane Separation and Gas Transport
- Salmonella and Campylobacter epidemiology
- Aluminum Alloys Composites Properties
- Pituitary Gland Disorders and Treatments
- Pharmaceutical and Antibiotic Environmental Impacts
- Neurological and metabolic disorders
- Microbial Community Ecology and Physiology
- Recycling and Waste Management Techniques
- Electroconvulsive Therapy Studies
- Neuroinflammation and Neurodegeneration Mechanisms
East China University of Technology
2025
Shanghai Mental Health Center
2021-2024
Xi'an Jiaotong University
2022-2024
Guangdong Academy of Sciences
2024
First Affiliated Hospital of Xi'an Jiaotong University
2023-2024
Shanghai Jiao Tong University
2022-2024
Hubei Cancer Hospital
2023
Guangxi University
2022-2023
Huazhong University of Science and Technology
2023
Chinese Academy of Medical Sciences & Peking Union Medical College
2019-2022
The gut-brain axis is implicated in depression development, yet its underlying mechanism remains unclear. We observed depleted gut bacterial species, including Bifidobacterium longum and Roseburia intestinalis, the neurotransmitter homovanillic acid (HVA) individuals with mouse models. Although R. intestinalis does not directly produce HVA, it enhances B. abundance, leading to HVA generation. This highlights a synergistic interaction among microbiota regulating intestinal production....
Abstract Hydrogel structures equipped with internal microchannels offer more in vivo‐relevant models for construction of tissues and organs vitro. However, currently used microfabrication methods constructing microfluidic devices are not suitable the handling hydrogel. This study presents a novel method fabricating hydrogel‐based chips by combining casting bonding processes. A twice cross‐linking strategy is designed to obtain interface that has same strength hydrogel bulk, which can be...
Xe is an ideal anesthetic gas, but it has not been widely used in practice due to its high cost and low output. Closed-circuit recovery recycling economically viable method ensure adequate supply medical use. Herein, we design innovative way recover by using a stable fluorinated metal-organic framework (MOF) NbOFFIVE-1-Ni eliminate CO2 from moist exhaled gases. Unlike other MOFs with Xe/CO2 selectivity (less than 10), could achieve absolute molecular sieve separation of /Xe excellent (825)....
Histone deacetylases (HDACs) function as key epigenetic factors in repressing the expression of genes multiple aspects plant growth, development and response to abiotic or biotic stresses. To date, molecular HDACs is well described Arabidopsis thaliana, but no systematic analysis this gene family soybean (Glycine max) has been reported.In study, 28 HDAC from genome were identified, which asymmetrically distributed on 12 chromosomes. Phylogenetic demonstrated that GmHDACs fall into three...
Abstract Immunological/inflammatory factors are implicated in the development of psychosis. Complement is a key driver inflammation; however, it remains unknown which factor better at predicting onset This study aimed to compare alteration and predictive performance inflammation complement individuals clinical high risk (CHR). We enrolled 49 CHR 26 healthy controls (HCs). Twenty-five patients had converted psychosis (converter) by 3-year follow-up. Inflammatory cytokines, including...
Abstract Efficient and inherently safe NH 3 storage separation are of significant importance for the chemical industry. Herein, we proposed zwitterionic COF as a porous host to disperse LiCl highly efficient with record adsorption capacity. The equivalently cationic anionic groups in channels could act two separated sites facilitate dispersion LiCl, hence optimal composite exhibits high capture capacity 44.98 mmol/g at 25 °C 1 bar, far exceeding other existing materials. Notably, is...
Microorganisms are used to alleviate heavy metal stress in plants cultivated contaminated fields. However, the relevant mechanisms have been rarely explored. The goal of this study was investigate effects arbuscular mycorrhizal fungus Funneliformis mosseae and two Cd-resistant bacterial strains (Enterobacter sp. EG16 Enterobacter ludwigii DJ3) on growth Cd tolerance tomato when applied with different inoculation strategies (single or dual) concentrations (50 100 mg kg−1). Better plant...
We report an approach that polymerizable handle-modified nanosized metal organic frameworks (MOFs) are used as independent monomers to be covalently organized by crosslinking molecules (CLMs) into orderly MOF-assembled hybrid monolithic stationary phase, overcoming the respective problems of previously reported MOF-mixed or embedded phases so far. It has a hierarchical micro-, meso-, and macropore structure throughout matrix is donated from MOF themselves, formed via CLM in-between MOFs...
The laser-induced breakdown spectroscopy (LIBS) technique coupled with machine learning was proposed to perform four metal elements quantitative analysis and pollution source discrimination in atmospheric sedimentation.
Immune alterations are associated with the progression of psychosis. However, there few studies designed to longitudinally measure inflammatory biomarkers during psychotic episodes. We aimed assess changes in from prodromal phase episodes individuals clinical high risk (CHR) psychosis and compare converters non-converters as well healthy controls (HCs).We enrolled 394 CHR 100 HCs. A total 263 completed 1-year follow-up, 47 had converted Interleukin (IL)-1β, 2, 6, 8, 10, tumor necrosis...
Numerous studies have established the roles of inflammation and angioneurins in pathogenesis schizophrenia (SCZ). This study aimed to compare serum levels tumour necrosis factor (TNF)-α vascular endothelial growth (VEGF) patients at clinical high risk (CHR) for psychosis or SCZ baseline one year after treatment.A total 289 CHR participants from Shanghai At Risk Psychosis Extended Program (SHARP) were tracked a year. They divided into two four subtypes based on symptom severity according...
The current concept of clinical high-risk(CHR) psychosis relies heavily on "below-threshold" (i.e. attenuated or limited and intermittent) psychotic positive phenomena as predictors the risk for future progression to "above-threshold" symptoms (aka "transition" "conversion"). Positive symptoms, even at levels are often treated with antipsychotics (AP) achieve stabilization mitigate psychopathological severity. goal this study is contextually examine clinicians' decision prescribe AP, CHR...
Non-alcoholic steatohepatitis (NASH) is a global medical problem and macrophages' activation closely related to the pathogenesis of NASH. Curcumin polyphenol from turmeric with significant anti-inflammatory activity.The objective present study was observe effect curcumin on secretion pro-inflammatory cytokines in NASH.Hematoxylin eosin TUNEL staining were used hepatic function. RT-PCR conducted evaluate mRNA expression tumor necrosis factor-α (TNF-α) interleukin-1β (IL-1β). Flow cytometry...
As an indispensable raw material for silicon-based semiconductor industry, carbon tetrafluoride (CF4) is widely used as plasma etching and cleaning gas in the manufacture of semiconductors. How to efficiently remove C2F6 impurity during CF4 production process a challenging task industry requires high-purity gas. Herein, two fluorine-functionalized porous organic frameworks (F-POFs) named SPPOF-4F SPPOF-8F were synthesized separation C2F6/CF4 gases. Single-component adsorption experiments...
Objective: Current treatment guidelines for individuals at clinical high risk (CHR) psychosis do not recommend the prescription of antipsychotics (not even second-generation ones) as first option preventing psychosis. Yet, recent meta-analytic evidence indicates that antipsychotic exposure in CHR is relatively widespread and associated with a higher imminent transition to Therefore, we undertook this study better delineate which characteristics may lead choice whether it identifies subgroup...
Background Impaired sensitivity of the skin flush response to niacin is one most replicated findings in patients with schizophrenia. However, prior studies have usually focused on postonset psychosis, and little known about clinical high-risk (CHR) phase psychosis. Aims To profile compare among CHR individuals (converters non-converters), first-episode schizophrenia (FES) healthy controls (HCs). Methods Sensitivity four concentrations (0.1–0.0001 M) aqueous methylnicotinate was tested 105...
Abstract Individuals at clinical high risk (CHR) for psychosis exhibit a compromised mismatch negativity (MMN) response, which indicates dysfunction of pre‐attentive deviance processing. Event‐related potential and time‐frequency (TF) information, in combination with cognitive profiles, may provide insight into the pathophysiology psychopathology CHR stage predict prognosis individuals. A total 92 individuals were recruited followed up regularly to 3 years. classified three subtypes...