A5079052592- Adipose Tissue and Metabolism
- Safety and Risk Management
- Regulation of Appetite and Obesity
- Inflammatory Biomarkers in Disease Prognosis
- Biochemical Analysis and Sensing Techniques
- Evaluation Methods in Various Fields
- Occupational Health and Safety Research
- Adipokines, Inflammation, and Metabolic Diseases
- Diet and metabolism studies
- Cardiovascular Health and Disease Prevention
- Cancer, Hypoxia, and Metabolism
- Exercise and Physiological Responses
- Liver Disease Diagnosis and Treatment
- Urologic and reproductive health conditions
- Pancreatic function and diabetes
- Evaluation and Optimization Models
- Cardiovascular Disease and Adiposity
- Muscle Physiology and Disorders
- Cancer-related molecular mechanisms research
- Bone health and osteoporosis research
- Gut microbiota and health
- Dietary Effects on Health
- Lipid metabolism and disorders
- Neuroscience and Neuropharmacology Research
- Endoplasmic Reticulum Stress and Disease
Zhongshan Hospital
2018-2025
Fudan University
2017-2025
Inner Mongolia University
2022-2025
Sun Yat-sen University
2018-2024
State Key Laboratory of Genetic Engineering
2018-2024
The First Affiliated Hospital, Sun Yat-sen University
2018-2024
Shenyang University of Chemical Technology
2011-2024
Shanxi Medical University
2024
First Hospital of Shanxi Medical University
2024
Shanghai University of Sport
2019-2023
The hormone ghrelin stimulates eating and helps maintain blood glucose upon caloric restriction. While previous studies have demonstrated that hypothalamic arcuate AgRP neurons are targets of ghrelin, the overall relevance signaling within intact is unclear. Here, we tested functional significance action on using a new, tamoxifen-inducible AgRP-CreER(T2) transgenic mouse model allows spatiotemporally-controlled re-expression physiological levels receptors (GHSRs) specifically in adult...
Energy and glucose homeostasis are regulated by central serotonin 2C receptors. These receptors attractive pharmacological targets for the treatment of obesity; however, identity receptor-expressing neurons that mediate effects receptor agonists on energy unknown. Here, we show mice lacking (Htr2c) specifically in pro-opiomelanocortin (POMC) had normal body weight but developed glucoregulatory defects including hyperinsulinemia, hyperglucagonemia, hyperglycemia, insulin resistance. Moreover,...
The gut-brain axis is implicated in depression development, yet its underlying mechanism remains unclear. We observed depleted gut bacterial species, including Bifidobacterium longum and Roseburia intestinalis, the neurotransmitter homovanillic acid (HVA) individuals with mouse models. Although R. intestinalis does not directly produce HVA, it enhances B. abundance, leading to HVA generation. This highlights a synergistic interaction among microbiota regulating intestinal production....
The molecular mechanisms underlying acute leptin and serotonin 2C receptor-induced hypophagia remain unclear. Here, we show that neuronal pro-opiomelanocortin (Pomc)-specific loss of transient receptor potential cation 5 (TrpC5) subunits is sufficient to decrease energy expenditure increase food intake resulting in elevated body weight. Deficiency Trpc5 Pomc neurons also block the anorexigenic effects (Ht2Cr) agonists. these receptors concomitant with a blunted electrophysiological response...
The hypothalamus plays a crucial role in the progression of obesity and diabetes; however, its structural complexity cellular heterogeneity impede targeted treatments. Here, we profiled single-cell spatial transcriptome obese sporadic type 2 diabetic macaques, revealing primate-specific distributions clusters genes as well region, cell-type-, gene-feature-specific changes. infundibular (INF) paraventricular nuclei (PVN) are most susceptible to metabolic disruption, with PVN being more...
Abstract Neurotensin (NTS) is a secretory peptide produced by lymphatic endothelial cells. Our previous study revealed that NTS suppressed the activity of brown adipose tissue via interactions with NTSR2. In current study, we found depletion Ntsr2 in white adipocytes upregulated food intake, while local treatment intake. mechanistic suppression NTS-NTSR2 signaling enhanced phosphorylation ceramide synthetase 2, increased abundance its products ceramides C20–C24, and downregulated production...
Platelets play a multifaceted role in cancer progression and metastasis. Mean platelet volume (MPV) distribution width (PDW) are commonly used parameters from routine blood test. The aim of the present study was to investigate correlation between indices prognosis patients with non-small cell lung (NSCLC). A total 270 who were diagnosed NSCLC January 2009 December retrospectively analyzed. Patients' characteristics hematologic tests data at initial diagnosis collected. overall survival rate...
Poly(ADP-ribose) polymerase-1 (PARP1) has been reported to play an important role in longevity. Here, we showed that the knockdown of PARP1 extended lifespan Drosophila , with particular emphasis on skeletal muscle. The muscle-specific mutant exhibited resistance starvation and oxidative stress, as well increased ability climb, enhanced mitochondrial biogenesis activity at older age. Mechanistically, inhibition increases AMP-activated protein kinase alpha (AMPKα) turnover. could interact...
Inter-organ crosstalk has gained increasing attention in recent times; however, the underlying mechanisms remain unclear. In this study, we elucidate an endocrine pathway that is regulated by skeletal muscle interferon regulatory factor (IRF) 4, which manipulates liver pathology. Skeletal specific IRF4 knockout (F4MKO) mice exhibited ameliorated hepatic steatosis, inflammation, and fibrosis, without changes body weight, when put on a nonalcoholic steatohepatitis (NASH) diet. Proteomics...
Adiponectin receptors (AdipoRs) are located on neurons of the hypothalamus involved in metabolic regulation - including arcuate proopiomelanocortin (Pomc) and Neuropeptide Y/Agouti-related peptide (NPY/AgRP) neurons. AdipoRs play a critical role regulating glucose fatty acid metabolism by initiating several signaling cascades overlapping with Leptin (LepRs). However, mechanism which adiponectin regulates cellular activity brain remains undefined.In order to resolve this issue, we utilized...