A5032354881- Cardiac Fibrosis and Remodeling
- Cardiovascular Function and Risk Factors
- GDF15 and Related Biomarkers
- Acute Myocardial Infarction Research
- Cardiac Imaging and Diagnostics
- Protease and Inhibitor Mechanisms
- Antiplatelet Therapy and Cardiovascular Diseases
- Cell Adhesion Molecules Research
- Lipoproteins and Cardiovascular Health
- Inflammatory Biomarkers in Disease Prognosis
- Apelin-related biomedical research
- Metabolomics and Mass Spectrometry Studies
- Coronary Interventions and Diagnostics
- Heart Rate Variability and Autonomic Control
- Signaling Pathways in Disease
- Cardiovascular Effects of Exercise
- Cardiovascular Health and Disease Prevention
- Urinary Bladder and Prostate Research
- Atherosclerosis and Cardiovascular Diseases
- Cardiovascular, Neuropeptides, and Oxidative Stress Research
- Cardiac electrophysiology and arrhythmias
- Heart Failure Treatment and Management
- Adipose Tissue and Metabolism
- RNA modifications and cancer
- Atrial Fibrillation Management and Outcomes
Peking University
2016-2025
Peking University Third Hospital
2016-2025
King University
2024-2025
Tianjin haihe hospital
2024
Chinese Academy of Medical Sciences & Peking Union Medical College
2024
Southern Medical University
2024
Nanfang Hospital
2024
Beijing National Laboratory for Molecular Sciences
2023
Ministry of Education of the People's Republic of China
2014-2021
82th Hospital of Pla
2016
Rapid over-activation of β-adrenergic receptor (β-AR) upon stress leads to cardiac inflammation, a prevailing factor that underlies heart injury. However, mechanisms by which acute β-AR stimulation induce inflammation still remain unknown. Here, we set out identify the crucial role inflammasome/interleukin (IL)-18 in initiating and maintaining inflammatory cascades insult.Male C57BL/6 mice were injected with single dose agonist, isoproterenol (ISO, 5 mg/kg body weight) or saline...
Abstract Blood lipids are important risk factors for coronary artery disease (CAD). Here we perform an exome-wide association study by genotyping 12,685 Chinese, using a custom Illumina HumanExome BeadChip, to identify additional loci influencing lipid levels. Single-variant analysis on 65,671 single nucleotide polymorphisms reveals 19 associated with at significance ( P <2.69 × 10 −7 ), including three Asian-specific coding variants in known genes CETP p.Asp459Gly, PCSK9 p.Arg93Cys and...
Abstract Neurotensin (NTS) is a secretory peptide produced by lymphatic endothelial cells. Our previous study revealed that NTS suppressed the activity of brown adipose tissue via interactions with NTSR2. In current study, we found depletion Ntsr2 in white adipocytes upregulated food intake, while local treatment intake. mechanistic suppression NTS-NTSR2 signaling enhanced phosphorylation ceramide synthetase 2, increased abundance its products ceramides C20–C24, and downregulated production...
The action of β-adrenergic receptors (β-ARs) induces cardiac fibroblast (CF) proliferation and collagen synthesis is a major source the fibrosis caused by various diseases. Recently, microRNA-214 (miR-214) was found to play an important role in pathogenesis remodelling. In present study, we examined underlying mechanism miR-214 isoproterenol (ISO, β-AR agonist)-induced CF synthesis. expression increased both ISO-mediated fibrotic heart tissue fibroblasts. Downregulation antagonists...
Background and Objectives: Myocardial hypertrophy is a common clinical finding leading to heart failure sudden death. Mitofusin 2 (Mfn2), hyperplasia suppressor protein, downregulated in hypertrophic heart. This study examined the role of Mfn2 myocardial its potential signal pathway. Methods Results: In vitro studies, neonatal cardiac myocytes were isolated cultured. Incubation cultured cardiomycytes with angiotensin II (Ang II) inhibited gene expression Mfn2; induced cell protein synthesis;...
Early identification for heart failure (HF) may be useful disease modifying treatment in order to reduce progression or even reverse it. In our previous studies, we have revealed a group of heat shock proteins (HSPs) which might related neonatal rat cardiomyocyte hypertrophy by proteomic approach. Here, confirm that HSPs, including HSP27 and HSP70, altered the early stage cardiac remodeling vivo animal model. Furthermore, plasma concentrations those HSPs their potential screening value were...
Haemodynamic disorders are common clinical findings in hypertension and lead to adverse cardiovascular events. However, the haemodynamic conditions models poorly understood. This study aimed observe characteristics of haemodynamics spontaneously hypertensive rats (SHRs) antihypertensive-treated SHRs. Twenty-four adult male SHRs Wistar-Kyoto (WKYs) were randomly divided into four groups treated for 7 days as follows: WKY-CON (WKYs + saline), WKY-NIF nifedipine, 50 mg/kg/day), SHR-CON (SHRs...
Enhanced External Counterpulsation (EECP) can chronically relieve ischemic chest pain and improve the prognosis of coronary heart disease (CHD). Despite its role in mitigating complications, EECP mechanisms behind therapeutic nature, such as effects on blood flow hemodynamics, are still not fully understood. This study aims to elucidate effect significant hemodynamic parameters arterial tree.A finite volume method was used conjunction with inlet pressure wave (surrogated by measured aortic...
Abstract Neuregulin‐1 (NRG‐1) is reported to be cardioprotective through the extracellular‐regulated protein kinase (ERK) 1/2 pathway in myocardial ischaemia‐reperfusion injury (MIRI). NOX4‐induced ROS activated NLRP3 inflammasome and exacerbates MIRI. This study aims investigate whether NRG‐1 can suppress NOX4 by ERK1/2 consequently inhibit NLRP3/caspase‐1 signal The infarct size (IS) was measured TTC‐Evans blue staining. Immunohistochemical staining, real‐time quantitative PCR (RT‐qPCR)...
Myocardial fibrosis is a key pathological change in variety of heart diseases contributing to the development failure, arrhythmias, and sudden death. Recent studies have shown that relaxin prevents reverses cardiac fibrosis. Endogenous expression was elevated setting disease; extent such up-regulation, however, insufficient exert compensatory actions, mechanism regulating poorly defined. In rat relaxin-1 (RLN1, Chr1) gene promoter region we found presence repeated guanine (G)-rich sequences,...
Exercise training protects against heart failure. However, the mechanism underlying protective effect of exercise on angiotensin II (Ang II)-induced cardiac fibrosis remains unclear.An model involving C57BL/6N mice and 6 weeks treadmill was used. Ang (1.44 mg/kg/day) administered to induce fibrosis. RNA sequencing bioinformatic analysis were used identify key factors mediating effects Primary adult mouse fibroblasts (CFs) in vitro. Adeno-associated virus serotype 9 overexpress POU domain,...
Identification of individuals in the early stage heart failure (HF) may allow earlier initiation disease-modifying treatment. We evaluated concentrations growth differentiation factor (GDF)-15 at different stages and its potential screening value 208 subjects. Plasma GDF-15 was measured by using an enzyme-linked immunosorbent assay. positively correlated with HF (r=0.804, p<0.001). In distinguishing patients B HF, area under curve 0.873 (p<0.001). These findings indicate that concentration...
Childhood obesity affects multiple organs in the body and is associated with both significant morbidity ultimately premature mortality. obesity, especially dyslipidemia, can lead to early atherosclerosis cardiovascular disease (CVD) adulthood. The detection of exhaled volatile organic compounds (VOCs) breath offers opportunity for discovery novel disease-specific biomarkers. This study aimed identify VOCs that correlate childhood accompanied by dyslipidemia.A total 82 overweight or obese...
Catestatin is a peptide which potent inhibitor of catecholamine secretion and played essential functions in the cardiovascular system. Previous research found that dramatic changes catestatin were associated with hemodynamics acute myocardial infarction (AMI) during first week after AMI symptoms onset, but whether also involved pathophysiological progression then predictor for outcomes not clear. The aim this study to determine correlation plasma levels at different time points prognosis...
The protective effect of Neuregulin-1 (NRG-1) on heart failure is well established. In this study, we assessed whether NRG-1 could protect the by mimicking cardioprotective effects ischaemic postconditioning (IP).We used a myocardial reperfusion injury rat model in vivo to compare NRG-1(3 μg/kg, iv. at onset reperfusion) and IP. Langendorff isolated perfusion experiments, erythroblastic leukaemia viral oncogene homolog 4 (ErbB4) inhibitor AG1478, phosphatidylinositol 3-kinase (PI3K) LY294002...
Abstract Background Currently, pathophysiological mechanisms of post‐acute sequelae coronavirus disease‐19‐cardiovascular syndrome (PASC‐CVS) remain unknown. Methods and results Patients with PASC‐CVS exhibited significantly higher circulating levels severe acute respiratory syndrome‐coronavirus‐2 spike protein S1 than the non‐PASC‐CVS patients healthy controls. Moreover, individuals high plasma concentrations elevated heart rates normalized low frequency, suggesting cardiac β‐adrenergic...
To measure plasma catestatin levels in patients with acute coronary syndrome and investigate whether there is an association between long-term outcome.Patients (n = 170) suspected who underwent emergency angiography were enrolled, including 46 ST-segment elevation myocardial infarction (STEMI), 89 unstable angina pectoris (UAP), 35 without artery disease (CAD). All followed for 2 years to the occurrence of major adverse cardiovascular events (MACEs), death from a cause, recurrent infarction,...
The mechanisms underlying the recurrence of atrial fibrillation (AF) after radiofrequency catheter ablation (RFCA) are not well concerned. study sought to explore association between growth differentiation factor-15 (GDF-15) and incidence recurrent events among AF patients procedure. We prospectively included 150 consecutive who underwent RFCA. Clinical information about was collected. Blood samples on second morning hospital admission three months RFCA were collected, enzyme-linked...
Exercise has proven cardiac benefits, but the underlying mechanisms of exercise that protect heart from acute sympathetic stress injuries remain unknown. In this study, adult C57BL/6J mice and their AMP-activated protein kinase α2 knockout (AMPKα2-/-) littermates were either subjected to 6 weeks training or housed under sedentary conditions then treated with without a single subcutaneous injection β-adrenergic receptor (β-AR) agonist isoprenaline (ISO). We investigated differences in...
Abstract Catestatin was discovered as a potent inhibitor of catecholamine secretion and plays important roles in the cardiovascular system. Our previous study demonstrates close relationship between catestatin levels prognosis ST-elevation myocardial infarction (STEMI). Using same population, goal this is to investigate ability predict left ventricular (LV) remodeling STEMI patients. 72 patients 30 controls were included. sampled after admission emergency room (ER), at day3 (D3), day7 (D7)...