A5032016310- Asthma and respiratory diseases
- Helicobacter pylori-related gastroenterology studies
- Ocular Diseases and Behçet’s Syndrome
- Cardiac, Anesthesia and Surgical Outcomes
- Gastroesophageal reflux and treatments
- Mast cells and histamine
- Pediatric health and respiratory diseases
- Eosinophilic Esophagitis
- Cardiac and Coronary Surgery Techniques
- Sphingolipid Metabolism and Signaling
- Cardiac Ischemia and Reperfusion
- Toxin Mechanisms and Immunotoxins
- Nutrition and Health in Aging
- Preterm Birth and Chorioamnionitis
- Urinary and Genital Oncology Studies
- Inflammasome and immune disorders
- Insurance, Mortality, Demography, Risk Management
- Cerebrovascular and Carotid Artery Diseases
- Diet and metabolism studies
- Veterinary medicine and infectious diseases
- Adipokines, Inflammation, and Metabolic Diseases
- Influenza Virus Research Studies
- Ectopic Pregnancy Diagnosis and Management
- Hyperglycemia and glycemic control in critically ill and hospitalized patients
- Cardiovascular Disease and Adiposity
Peking University Third Hospital
2015-2025
Peking University
2015-2025
Henan Provincial Eye Hospital
2025
Henan Provincial People's Hospital
2025
Dalian Medical University
2025
Second Affiliated Hospital of Dalian Medical University
2025
Dalian University of Technology
2025
Huazhong University of Science and Technology
2006-2021
Viral infections constitute a primary trigger for asthma exacerbations. While vaccines protect against viral by eliciting Th1 immune response, the impact of asthmatic milieu which is characterized Th2 cytokine dominance and elevated IgE levels on post-vaccination antibody production remains elusive. Therefore, vaccination protocols tailored to patients need be formulated. The IgG specific SARS-CoV-2 S protein were measured in sera vaccinated unvaccinated individuals ELISA. differences titers...
Objective: To investigate the prevalence of blindness and visual impairment in adults related causes China. Methods: A population-based cross-sectional survey was conducted during 2021 2022 among 13 provinces, municipalities, autonomous regions, including Beijing, Hebei, Jiangsu, Shanghai, Guangdong, Henan, Shanxi, Ningxia Hui Autonomous Region, Chongqing, Yunnan, Sichuan, Heilongjiang, Liaoning. Respondents were aged 18 years above, classified into groups young (18 to 39 years), middle-age...
Radical nephroureterectomy (RNU) is the gold standard therapy for patients with upper urinary tract urothelial carcinoma (UTUC). In this study, we compared effect of two surgical techniques, single-position complete retroperitoneoscopic radical (SCRNU) and laparoscopic open bladder cuff excision (LNOBE), on perioperative long-term oncological outcomes in UTUC patients. We retrospectively collected information baseline characteristics, clinicopathological approaches, data, survival from 174...
Background Renal anastomosing hemangioma (RAH) is a rare benign renal tumor, and its clinicopathologic characteristics genetic mutation spectrum related to mechanisms of pathogenesis are unclear. Methods We carried out whole-genome sequencing (WGS) on RAH samples explore the verified results by Sanger sequencing. Immunohistochemical analysis was also performed reveal histopathological tumor microenvironment components. Moreover, population-based study conducted after searching PubMed,...
The protective effect of Neuregulin-1 (NRG-1) on heart failure is well established. In this study, we assessed whether NRG-1 could protect the by mimicking cardioprotective effects ischaemic postconditioning (IP).We used a myocardial reperfusion injury rat model in vivo to compare NRG-1(3 μg/kg, iv. at onset reperfusion) and IP. Langendorff isolated perfusion experiments, erythroblastic leukaemia viral oncogene homolog 4 (ErbB4) inhibitor AG1478, phosphatidylinositol 3-kinase (PI3K) LY294002...
Background: SARS-CoV-2 tends to cause more severe disease in patients with COPD once they are infected. We aimed investigate the rates of influenza, pneumococcal and COVID-19 vaccination uptake determine whether pandemic widespread against had any impact on intention accept influenza vaccines these patients. Methods: conducted a multi-center cross-sectional survey seven tertiary hospitals Beijing consecutively recruited outpatients from June 1st July 30th, 2021. The included patient's...
Previous studies have established that disturbed lymphocytes are involved in the pathogenesis of Vogt-Koyanagi-Harada (VKH) syndrome. Accordingly, glucocorticoids (GCs), with their well-recognized immune-suppressive function, been widely used for treatment VKH patients acute relapses. However, systemic response diverse immune cells to GC therapy is poorly characterized. To address this issue, we analyzed cell subpopulations and phenotype, as well cytokine profiles peripheral blood from...
<title>Abstract</title> Background Sphingolipids metabolism regulated by ceramide synthase (<italic>CerS</italic>) enzyme is closely related to asthma development, but the underlying biological mechanism remains unclear. Given critical role of epigenetics in pathogenesis asthma, we explored DNA methylation patterns <italic>CerS1-6</italic>, genes encoding <italic>CerS</italic> enzyme, patients. Methods We enrolled 26 patients and six healthy controls for this study. Peripheral blood samples...
It is becoming increasingly clear that environment factors during early life play a pivotal role in the development of allergic asthma. Among these, traditional farm one strongest protective environments, and effects have been, at least part, attributed to high-level exposure lipopolysaccharide (LPS) on farms. However, underlying mechanisms remain elusive, especially ovalbumin (OVA)-induced neonatal asthma model. Here, we used OVA-induced model two age groups, adult, when mice were first...
Asthma is a heterogeneous disease with distinct prevalence and manifestation between sexes. This study was to identify sex-specific features of asthma via metabolomic analysis sphingolipids.Forty-two patients (27 women 15 men) admitted the Peking University Third Hospital from January 2015 December were enrolled. Peripheral venous blood collected for by targeted liquid chromatography-mass spectrometry. Sex hormones(estradiol, progesterone, testosterone, androstenedione) multiple inflammatory...
Background Sphingolipids metabolism regulated by ceramide synthase (CerS) enzyme is closely related to asthma development, but the underlying biological mechanism remains unclear. Since epigenetics plays a critical role in pathogenesis of asthma, we thus studied DNA methylation CerS1-6 , genes coding CerS patients. Methods We enrolled 26 patients and 6 healthy controls. After collecting demographic clinical information, peripheral blood was collected analyze serum phospholipid profile assay....
Objective We retrospectively analyzed the results of coronary angiography in patients with and without chronic obstructive pulmonary disease (COPD) explored relationship between COPD severity atherosclerosis. Methods Data undergoing lung function testing our hospital from July 2007 to October 2013 were collected.According testing, divided into non-COPD.Number affected arteries, total number lesions Gensini′s score compared two groups. Results Eighty-five included groups: (n=31)...
Objective: To summarize the early experience and clinical value of minimally invasive coronary surgery-total arterial revascularization (MICS-TACR) through left anterior small incision. Methods: Between May 2015 June 2018, a total 31 consecutive cases [21 males 10 females, aged (63.2±9.3) years] in Peking University Third Hospital who were performed MICS-TACR with bilateral internal mammary artery radial enrolled. Meanwhile, 1 489 conventional median sternal incision off-pump bypass grafting...