A5020875892- Fatty Acid Research and Health
- Tissue Engineering and Regenerative Medicine
- Ginseng Biological Effects and Applications
- Birth, Development, and Health
- Trace Elements in Health
- Gestational Diabetes Research and Management
- Heavy Metal Exposure and Toxicity
- Adipose Tissue and Metabolism
- Advanced Glycation End Products research
- Pregnancy and preeclampsia studies
- Cardiovascular Function and Risk Factors
- Electrospun Nanofibers in Biomedical Applications
- Endoplasmic Reticulum Stress and Disease
- Adipokines, Inflammation, and Metabolic Diseases
- Autophagy in Disease and Therapy
- Diet, Metabolism, and Disease
- Cardiovascular Disease and Adiposity
- Regulation of Appetite and Obesity
- Diet and metabolism studies
- Selenium in Biological Systems
- Nanoparticles: synthesis and applications
- Liver Disease Diagnosis and Treatment
- Colorectal Cancer Treatments and Studies
- Genomics, phytochemicals, and oxidative stress
- Extracellular vesicles in disease
First Hospital of Jilin University
2014-2024
Jilin University
2015-2024
Aerospace Center Hospital
2013-2023
Qiqihar Medical University
2010-2021
Jilin Medical University
2014-2021
University of Louisville
2017-2020
Norton Hospital
2020
Kosair Children's Hospital
2020
First Bethune Hospital of Jilin University
2015
Peking University
2013
Diabetic cardiomyopathy (DCM) is a prevalent myocardial microvascular complication of the myocardium with complex pathogenesis. Investigating pathogenesis DCM can significantly contribute to enhancing its prevention and treatment strategies. Our study revealed an upregulation lysine acetyltransferase 2 A (Kat2a) expression in DCM, accompanied by decrease N6-methyladenosine (m6A) modified Kat2a mRNA levels. Functionally, inhibition effectively ameliorated high glucose-induced cardiomyocyte...
Abstract Ginsenoside Rg1 has been demonstrated to have cardiovascular protective effects. However, whether the cardioprotective effects of ginsenoside are mediated by endoplasmic reticulum ( ER ) stress‐induced apoptosis remain unclear. In this study, among 80 male Wistar rats, 15 rats were randomly selected as controls; remaining 65 received a diet rich in fat and sugar content for 4 weeks, followed intraperitoneal injection streptozotocin STZ , 40 mg/kg) establish diabetes model. Seven...
Changes of gastrointestinal motility, which are important related to the food digestion and absorption in tract, may be one factors obesity-formation.
Introduction: Colonic pseudolipomatosis is a rare benign lesion with distinct endoscopic and histological features. The etiology pathogenesis of colonic have not been fully clarified are still controversial to some extent. It particularly noteworthy that this must be differentiated from real pathological entities avoid further unnecessary auxiliary examinations overtreatments. Case Presentation: We report case 61-year-old woman who underwent regular postoperative follow-ups rectal cancer....
This study aimed to investigate if ellagic acid has beneficial effects on cognitive deficits in middle-aged overweight individuals and propose a possible mechanism. A total of 150 male participants, including 76 normal-weight 74 men, aged between 45 55 years, were recruited for this study. Both participants administered either 50 mg or placebo cellulose daily 12 weeks. Blood lipids, peripheral brain-derived neurotrophic factor (BDNF), saliva cortisol assessed the last day procedure induced...
Abstract Diabetic cardiomyopathy (DCM) is a cardiac complication resulting from long‐term uncontrolled diabetes, characterized by myocardial fibrosis and abnormal function. This study aimed at investigating the potential of ginsenoside RG1 (RG1)‐induced mesenchymal stem cells (MSCs) in alleviating DCM. A DCM mouse model was constructed, effects RG1‐induced MSCs on function diabetic mice were evaluated. cocultured with high glucose‐treated fibroblasts for subsequent functional mechanism...
Obesity is linked to metabolic diseases characterized by insulin resistance, such as diabetes and cardiovascular disease. In this study, we investigated the disorders of uncomplicated obesity identify early alterations in biological systems.Metabolic differences between overweight/obese (n=36) normal-weight (n=35) young Chinese men without known were assessed. Metabolic profiling serum urine was performed using ultra-performance liquidchromatography quadrupole-time-of-flight mass...
Abstract Our previous studies have assessed ginsenoside Rg1 (Rg1)‐mediated protection in a type 1 diabetes rat model. To uncover the mechanism through which protects against cardiac injury induced by diabetes, we mimicked diabetic conditions culturing H9C2 cells high glucose/palmitate. had no toxic effect, and it alleviated glucose/palmitate damage dose‐dependent manner, as indicated 3‐(4,5‐dimethylthiazol‐2‐yl)‐2,5‐diphenyl tetrazolium bromide assay lactate dehydrogenase release to culture...
Polyunsaturated fatty acid (PUFA) in breast milk provides physiological benefits for offspring and is closely related to endogenous biosynthesis lactating women. Few studies have addressed the association between desaturase (FADS) gene expression patterns acids milk. This research aimed explore differences PUFA levels among groups with different of FADS provide a scientific basis precision nutrition strategies. A total 50 healthy women 42-45 days postpartum were included this study. basic...
Both diabetes and angiotensin II (Ang II) excess trigger cardiac remodeling dysfunction, diabetic cardiomyopathy. We hypothesized that hypertrophy associated with the development of cardiomyopathy is worsened by increased Ang II. Male type 1 OVE26 wild-type mice were given (sc., 1.15 mg/kg, twice a day) for 14 days. Diabetes-induced dysfunction was exacerbated treatment as determined echocardiography, wheat germ agglutinin staining atrial natriuretic peptide. dramatically diabetes-caused...
This study aimed to explore the effects and mechanisms of maternal gestational diabetes mellitus (GDM) selenium (Se) deficiency on growth glucose metabolism offspring. Female C57BL/6J mice were divided into four groups as follows: a control group, GDM Se with group. animal models established via S961. Pregnant fed their offspring until weaning. Then, continued be basic diet adulthood. Body weight fasting blood measured weekly. content, oxidative stress indicators, protein expression PI3K/Akt...
To investigate abdominal fat distribution in Chinese subjects with diabetes and its correlation different types of diabetes. A total 176 diabetic were enrolled, 92 type 1 84 2, a mean age 27.41 49.3 yrs. No subject has history severe diseases. Multi-slice CT was used to measure adipose (TA) visceral (VA) tissues. Subcutaneous (SA) tissue obtained by subtracting VA from TA. There differences between T1DM T2DM for TA, VA, SA, VA/SA, body mass index (BMI), triglyceride (TG) high density...
Inflammation and its subsequent endothelial dysfunction have been reported to play a pivotal role in the initiation progression of chronic vascular diseases. Inhibiting attachment monocytes endothelium is potential therapeutic strategy for diseases treatment. α-Melanocyte stimulating hormone generated from precursor called proopiomelanocortin by post-translational processing. However, whether α-melanocyte plays regulating inflammation still unknown. In this study, effects on human umbilical...