Xiaojin Zhang

ORCID: 0000-0002-1476-5069
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About
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Research Areas
  • Liver Disease Diagnosis and Treatment
  • Sexual function and dysfunction studies
  • Male Reproductive Health Studies
  • Reproductive Health and Technologies
  • Cardiovascular Function and Risk Factors
  • Cancer, Lipids, and Metabolism
  • Gout, Hyperuricemia, Uric Acid
  • Alcohol Consumption and Health Effects
  • Lipoproteins and Cardiovascular Health
  • Heart Failure Treatment and Management
  • Heat shock proteins research
  • Gastroesophageal reflux and treatments
  • Lipid metabolism and disorders
  • Biochemical Acid Research Studies
  • Medical Imaging Techniques and Applications
  • Hormonal and reproductive studies
  • Adipose Tissue and Metabolism
  • Cardiovascular Disease and Adiposity
  • Diabetes, Cardiovascular Risks, and Lipoproteins
  • Cardiac Valve Diseases and Treatments
  • Hormonal Regulation and Hypertension
  • Cardiomyopathy and Myosin Studies
  • Cardiac Fibrosis and Remodeling
  • Acupuncture Treatment Research Studies
  • Medical Education and Admissions

Nanjing Medical University
2019-2024

Jiangsu Province Hospital
2020-2024

Chengdu University of Traditional Chinese Medicine
2019-2022

Hubei University
2022

Wenzhou Medical University
2021

Weatherford College
2019

Obstetrics and Gynecology Hospital of Fudan University
2010-2019

Xinjiang Medical University
2015-2019

Beijing Anding Hospital
2017

First Affiliated Hospital of Xinjiang Medical University
2015

Cardiac fibroblasts (CFs) regulate myocardial remodeling by proliferating, differentiating, and secreting extracellular matrix proteins. Prolonged activation of CFs leads to cardiac fibrosis reduced contractile function. Resveratrol (RES) exhibits a number cardioprotective properties; however, the possibility that this compound affects CF function has not been considered. The current study tests whether RES directly influences growth proliferation differentiation hypersecretory myofibroblast...

10.1152/ajpheart.00763.2004 article EN AJP Heart and Circulatory Physiology 2004-10-21

Current surgical management of volume overload-induced heart failure (HF) leads to variable recovery left ventricular (LV) function despite a return LV geometry. The mechanisms that prevent restoration are unknown but may be related the timing intervention and degree contractile impairment. This study determined whether reduction aortocaval fistula (ACF)-induced overload during compensatory stage HF results in beneficial structural remodeling pump function. Rats were subjected ACF for 4 wk;...

10.1152/japplphysiol.00691.2011 article EN Journal of Applied Physiology 2011-09-02

Abstract Background: Endometrial thickness has been identified as a prognostic factor for pregnancy rate patients with female infertility. Thin endometrium is defined <7 mm on the day of ovulation, or human chorionic gonadotrophin (HCG) injection in fresh vitro fertilization (IVF) cycles, to start progesterone frozen-thaw embryo transfer stated guideline thin from Canadin Fertility and Andrology Society Chinese expert consensus Reproductive Medicine, Medical Association. Many medicines...

10.1097/md.0000000000018848 article EN cc-by-nc Medicine 2020-01-01

Aortocaval fistula (ACF)-induced volume overload (VO) heart failure (HF) results in progressive left ventricular (LV) dysfunction. Hemodynamic load reversal during pre-HF (4 wk post-ACF; REV) rapid structural but delayed functional recovery. This study investigated myocyte and myofilament function ACF REV tested the hypothesis that a Ca(2+) sensitizer would improve VO-induced dysfunction REV. Following initial sham or surgery male Sprague-Dawley rats (200-240 g) at week 0, experiments were...

10.1152/ajpheart.00423.2014 article EN AJP Heart and Circulatory Physiology 2014-09-27

Serum preβ1-high density lipoprotein (preβ1-HDL) was defined by two-dimensional non-denaturing linear gel electrophoresis and apolipoprotein A-I immuno-blotting. preβ1-HDL seems to play an important role in reverse cholesterol transport, a well-known anti-atherosclerosis process. However, there are still debatable questions for its quantification coronary artery disease (CAD) relevance. We isolated the using new native polyacrylamide (PAGE) system lipid pre-staining serum. established...

10.1186/s12986-016-0093-y article EN cc-by Nutrition & Metabolism 2016-05-17

Male fertility has gradually become a worldwide problem. Because of the limitation treatment, many drugs have been used for improving sperm quality. Among them, alpha-lipoic acid (ALA), as treatment diabetic neuropathy, applied to improve quality in clinical practice, with satisfactory effect. However, there is still no systematic review on field male infertility treating oral ALA.The databases MEDLINE, EMBASE, Web Science, Clinicaltrials.org., China National Knowledge Infrastructure...

10.1097/md.0000000000018453 article EN cc-by-nc Medicine 2019-12-01

To investigate abdominal fat distribution in Chinese subjects with diabetes and its correlation different types of diabetes. A total 176 diabetic were enrolled, 92 type 1 84 2, a mean age 27.41 49.3 yrs. No subject has history severe diseases. Multi-slice CT was used to measure adipose (TA) visceral (VA) tissues. Subcutaneous (SA) tissue obtained by subtracting VA from TA. There differences between T1DM T2DM for TA, VA, SA, VA/SA, body mass index (BMI), triglyceride (TG) high density...

10.1155/2013/651462 article EN cc-by Journal of Diabetes Research 2013-01-01

Abstract Objective This research aims to study the influence mechanism of psychological contract on turnover intention primary medical staff in context Corona Virus Disease 2019 (COVID‐19) fighting. Methods Six hundred and fifteen from 13 health care institutions Jianghan District, Wuhan City, Hubei Province, China were selected by random sampling. Psychological contract, emotional exhaustion questionnaires adjusted appropriately according needs, 5‐point Likert scale was used measure....

10.1002/hpm.3533 article EN The International Journal of Health Planning and Management 2022-06-16

10.1016/j.bbadis.2019.02.017 article EN publisher-specific-oa Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease 2019-02-22

<title>Abstract</title> Proliferation of renal tubular epithelial cells (TEC) is essential to restore integrity and thereby support functional recovery from kidney ischemia/reperfusion (KI/R) injury. The transcriptional factor c-Myc activated for TEC proliferation following KI/R; however, the in-depth mechanism activation in KI/R incompletely known. Heat shock protein A12A (HSPA12A) an atypic member HSP70 family. In this study, we found that decreased HSPA12A expression mouse kidneys TEC,...

10.21203/rs.3.rs-4633628/v1 preprint EN Research Square (Research Square) 2024-07-16

Male infertility is a worldwide problem with limitations in the treatment. Phosphodiesterase-5 inhibitors (PDE5is) first choice for treatment of erectile dysfunction (ED), but more and studies show that it has certain effect on male recent years. The literatures PDE5is related to have shown inconsistent results, there currently no high quality systematic review evaluate effects semen patients.The electronic databases MEDLINE, PubMed, Web Science, EMBASE, Clinicaltrials.org, China National...

10.1097/md.0000000000018317 article EN Medicine 2019-12-01

To evaluate, side by side, the efficiency of dried blood spots (DBSs) against serum screening for Down’s syndrome, and then, to construct a two-tier strategy topping up fetal cell-free DNA (cfDNA) secondary over high-risk women marked primary testing build practical tactic identify syndrome. One thousand eight hundred thirty-seven low-risk Chinese women, with singleton pregnancy, were enrolled study. Alpha-fetoprotein free beta human chorionic gonadotropin measured as well parallel DBS...

10.1177/1535370216683837 article EN Experimental Biology and Medicine 2017-01-05

This study investigated whether drugs with (milrinone (Mil), levosimendan (Levo)) and without (omecamtiv mecarbil (OM)) demonstrated phosphodiesterase (PDE) 3 inhibitory activity improve diastolic function in rats aortocaval fistula (ACF)‐induced volume overload (VO). ACF or sham surgery was performed male Sprague‐Dawley (200‐240g) 8 weeks prior to acute IV infusion either Levo (2.8 µg/kg/min), Mil (9.9 OM (11.7 µg/kg/min) vehicle (Veh; 0.4% DMSO) for 30 min. improved compared Veh (tau; 9.0...

10.1096/fasebj.28.1_supplement.837.1 article EN The FASEB Journal 2014-04-01
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