A5070498614- Lipoproteins and Cardiovascular Health
- Diabetes, Cardiovascular Risks, and Lipoproteins
- Genomics and Chromatin Dynamics
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Cancer, Lipids, and Metabolism
- Cancer-related molecular mechanisms research
- RNA modifications and cancer
- Cancer Genomics and Diagnostics
- Neonatal Respiratory Health Research
- Liver Disease Diagnosis and Treatment
- Epigenetics and DNA Methylation
- Genetic Mapping and Diversity in Plants and Animals
- Bioinformatics and Genomic Networks
- Peroxisome Proliferator-Activated Receptors
- Nosocomial Infections in ICU
- Pregnancy and preeclampsia studies
- Metabolism, Diabetes, and Cancer
- Neonatal and fetal brain pathology
- Lipid metabolism and disorders
- Pneumonia and Respiratory Infections
- Hepatitis B Virus Studies
- Pediatric health and respiratory diseases
- Computational Drug Discovery Methods
- Mycotoxins in Agriculture and Food
- Ferroptosis and cancer prognosis
Jiangsu University
2025
Fudan University
2011-2024
The First People's Hospital of Wenling
2020-2024
Hunan Agricultural University
2021-2023
Jiangxi Science and Technology Normal University
2023
Sun Yat-sen University
2010-2022
The First Affiliated Hospital, Sun Yat-sen University
2010-2022
Zhongshan Hospital
2010-2022
Ten Chen Hospital
2022
Shanghai Jiao Tong University
2017-2021
The Friedewald formula (FF) is useful for calculating serum low-density lipoprotein cholesterol (LDL-C) values, but has a remarkable deviation and limitation especially in hypertriglyceridemia. We modify the which now more suitable LDL-C calculation. 2180 cases were classified into three groups according to their TG concentrations (A: < 200 mg/dl, n = 1220; B: 200-400 480; C: 400-1000 480). of measured or estimated by 1) direct measurement (DM); 2) FF; 3) our modified (MFF): (mg/dl)...
Bactrian camels serve as an important means of transportation in the cold desert regions China and Mongolia. Here we present a 2.01 Gb draft genome sequence from both wild domestic bactrian camel. We estimate camel to be 2.38 Gb, containing 20,821 protein-coding genes. Our phylogenomics analysis reveals that shared common ancestors with other even-toed ungulates about 55–60 million years ago. Rapidly evolving genes lineage are significantly enriched metabolic pathways, these changes may...
Increasing evidence suggests a critical role for mitochondrial aldehyde dehydrogenase 2 (ALDH2) in protection against cardiac injuries; however, the downstream cytosolic actions of this enzyme are largely undefined.Proteomic analysis identified significant downregulation ALDH2 heart rat failure model after myocardial infarction. The mechanistic insights underlying action were elucidated using murine models overexpressing or its mutant with ablation gene (ALDH2 knockout) and neonatal...
To gain molecular insights of HBV integration that may contribute to HCC tumorigenesis, we performed whole transcriptome sequencing and genome copy number profiling hepatocellular carcinoma (HCC) samples from 50 Chinese patients. We identified a total 33 HBV-human sites in 16 44 HBV-positive tissues, which were enriched genotype C-infected In addition, significantly recurrent HBV-MLL4 (18%; 8/44) was found this cohort Using long-range PCR Sanger sequencing, comprehensively characterized gDNA...
ABSTRACT To realize the wideband and efficient operation of Doherty power amplifier (DPA) in multi‐band mode, this paper proposes a tri‐band DPA design method based on phase impedance‐constrained optimization. First, phases required for impedance transformation networks across are determined when operates at back‐off (BOP) saturation. Then, judgment using multiple constraint circles was employed to determine optimal load impedances. Finally, constraints frequencies were used optimize carrier...
Single-cell RNA sequencing (scRNA-seq) is a powerful tool for characterizing tumor heterogeneity, yet accurately identifying malignant cells remains challenging. Here, we propose scMalignantFinder, machine learning specifically designed to distinguish from their normal counterparts using data- and knowledge-driven strategy. To develop the tool, multiple cancer datasets were collected, initially annotated calibrated nine carefully curated pan-cancer gene signatures, resulting in over 400,000...
Infections of the prostate by bacteria, human papillomaviruses, polyomaviruses, xenotropic murine leukemia virus (MLV)-related gammaretroviruses, cytomegaloviruses and other members herpesvirus family have been widely researched. However, many studies yielded conflicting controversial results. In this study, we systematically investigated transcriptomes samples for unique genomic signatures these pathogens using RNA-seq data from both western Chinese patients. Human nonhuman reads were...
Tandem mass spectrometry (MS/MS) technology has been applied to identify proteins, as an ultimate approach confirm the original genome annotation. To be able gene fusion a special database containing peptides that cross over breakpoints is needed.It impractical construct includes all possible originated from potential breakpoints. Focusing on 6259 reported and predicted pairs ChimerDB 2.0 Cancer Gene Census, we for first time created CanProFu comprehensively annotates formed by exon-exon...
The burden of symptoms and risk exacerbations are the main drivers overall assessment Chronic Obstructive Pulmonary Disease (COPD) adequate treatment approaches per current Global Initiative for Lung (GOLD). Physical activity has emerged as both functional outcome non-pharmacological intervention in COPD patients, despite lack standardized measures or guidelines clinical practice. This study aimed to explore more depth 24-h respiratory symptoms, physical level (PAL) relationship between...
Synthetic lethality (SL) has emerged as a promising approach to cancer therapy. In contrast the costly and labour-intensive genome-wide siRNA or CRISPR-based human cell line screening approaches, computational approaches prioritize potential synthetic pairs for further experimental validation represent an attractive alternative. this study, we propose efficient comprehensive in-silico pipeline rank novel SL gene by mining vast amounts of accumulated tumor high-throughput sequencing data in...
Complicated skin and soft tissue infections (cSSTI) are some of the most commonly treated in hospitals, place heavy economic burdens on patients society. Here we report findings from an analysis cSSTI based a retrospective study which was conducted within Chinese inpatient population. We focused our research patient population, antibiotic treatment, clinical outcome burden. The population comprised 527 selected hospitalized between 2008 2013. Among hospitalizations with microbiological...
Abstract: Urinary tract infections (UTIs) are common nosocomial infections. This study evaluated the prevalence, pathogens, antibiotic resistances, clinical outcomes, and hospitalization costs associated with complicated UTIs in southern China, risk factors delaying patient discharge. We retrospectively reviewed electronic medical records of 4,284 (61.4% women) UTI-related hospitalizations from 2008 to 2013. Average age was 61.1 years median hospital stay 11 days. Pathogens were isolated...
The Goto-Kakizaki (GK) rat, which has been developed by repeated inbreeding of glucose-intolerant Wistar rats, is the most widely studied rat model for Type 2 diabetes (T2D). However, detailed genetic background T2D phenotype in GK rats still largely unknown. We report a survey susceptible variations based on high-quality whole genome sequencing and have generated list GK-specific (228 structural variations, 2660 CNV amplification 2834 deletion, 1796 protein affecting SNVs or indels)...
Breast cancer is a significant health issue both globally and within China. Here, we present epidemiological data for female patients diagnosed with breast treated at West China Hospital, Sichuan University, between 2005 2009. Patients who were 2009 enrolled. Data cut-off in this analysis was October 2013, allowing minimum of 3 years' follow-up, or follow-up until death. collected subject to statistical analyses assess relationships patient characteristics, treatment patterns long-term...
Abstract Background Transcriptional interactome of chromatin is one the important mechanisms in gene transcription regulation. By conformation capture and 3D FISH experiments, several interactions cases among sequence-distant genes or even inter-chromatin were reported. However, on genomics level, there still little evidence to support these mechanisms. Recently based Hi-C experiment, a genome-wide picture human cells was presented. It provides useful material for analysing whether mechanism...
Background: Nasopharyngeal carcinoma (NPC) is an Epstein-Barr virus (EBV)-associated epithelial malignancy.Large-scale genetics or epigenetics studies of NPC have been relatively scarce and sporadic, there are no effective targeted drugs for NPC.Integrative analysis multiple different omics profiles has proved to be approach shed new light on cancer.Methods: We developed a pipeline aggregate consensus differentially expressed genes (DEGs) from expression datasets platforms.Integrated...
Phospholipid transfer protein (PLTP) is highly expressed in adipose tissues. Thus, the effect of tissue PLTP on plasma lipoprotein metabolism was examined.We crossed PLTP-Flox-ΔNeo and adipocyte 2 (aP2)-Cre recombinase (Cre) transgenic mice to create PLTP-Flox-ΔNeo/aP2-Cre that have a 90 60% reduction mRNA macrophages, respectively. ablation resulted significant activity (22%), high-density lipoprotein-cholesterol (21%), lipoprotein-phospholipid (20%), apolipoprotein A-I (33%) levels, but...