A5048353180- Cardiac Imaging and Diagnostics
- Acute Myocardial Infarction Research
- Cardiovascular Function and Risk Factors
- Heart Failure Treatment and Management
- Neonatal Respiratory Health Research
- Phytoestrogen effects and research
- Viral Infections and Immunology Research
- Cardiac, Anesthesia and Surgical Outcomes
- MicroRNA in disease regulation
- Hypothalamic control of reproductive hormones
- Cardiac Fibrosis and Remodeling
- Cancer, Hypoxia, and Metabolism
- Atrial Fibrillation Management and Outcomes
- Neuroscience and Neuropharmacology Research
- Venous Thromboembolism Diagnosis and Management
- Adipose Tissue and Metabolism
- Peroxisome Proliferator-Activated Receptors
- Signaling Pathways in Disease
- Advanced Polymer Synthesis and Characterization
- Blood Pressure and Hypertension Studies
- Animal Nutrition and Physiology
- Nanoparticle-Based Drug Delivery
- Cell Adhesion Molecules Research
- Cancer-related molecular mechanisms research
- Cardiac tumors and thrombi
Gansu Provincial Hospital
2024-2025
Capital Medical University
2012-2025
Beijing Friendship Hospital
2010-2025
Capital Normal University
2016-2024
Dingxi City People's Hospital
2023-2024
Beijing University of Chinese Medicine
2023-2024
Beijing Obstetrics and Gynecology Hospital
2024
Ministry of Ecology and Environment
2024
University of Minnesota System
2024
Nanchang University
2023
Bactrian camels serve as an important means of transportation in the cold desert regions China and Mongolia. Here we present a 2.01 Gb draft genome sequence from both wild domestic bactrian camel. We estimate camel to be 2.38 Gb, containing 20,821 protein-coding genes. Our phylogenomics analysis reveals that shared common ancestors with other even-toed ungulates about 55–60 million years ago. Rapidly evolving genes lineage are significantly enriched metabolic pathways, these changes may...
Since it was first described in 1968, immunoglobulin (Ig)A nephropathy (IgAN) has become the most commonly diagnosed form of primary glomerular disease worldwide. A number reports have shown that toll‑like receptor 9 (TLR9) and B‑cell activating factor (BAFF) may be associated with IgAN; however, sufficient evidence not yet to delivered. In present study, serum levels BAFF as well TLR9 mRNA protein peripheral blood mononuclear cells (PBMCs) were assessed. Expression PBMCs examined by...
Objective: Janus kinase (JAK)-signal transducer and activator of transcription (STAT) signaling pathway is closely related to tumorigenesis. Suppressors cytokine 3 (SOCS3) a negative regulator JAK-STAT pathway. MiR-340 expression significantly upregulated in gastric cancer (GC) tissue. This study investigated the role miR-340 regulating SOCS3 affecting GC cell proliferation, cycle, apoptosis.Patients methods: Dual luciferase assay was used verify targeted relationship between SOCS3. tissue...
Cardiac dysfunction in diabetic cardiomyopathy may be associated with abnormal Ca2+ homeostasis. This study investigated the effects of alterations homeostasis and sarcoplasmic reticulum Ca2+-associated proteins on cardiac function development cardiomyopathy. Sprague–Dawley rats were divided into 4 groups (n = 12, each): a control group, streptozotocin-induced rat models diabetes groups, examined after 4, 8, or 12 weeks. Evaluations structure performed by echocardiography hemodynamic...
Hepatocellular carcinoma (HCC) is the sixth most lethal neoplasm worldwide. Traditional biomarkers often exploit relationship between a certain gene and cancer progression, but they cannot predict patient survival or prognosis accurately. We aim to construct new DNA repair-related signature that combines several genes improve prediction in HCC.We selected an HCC mRNA sequencing (mRNA-seq) dataset (n=365) from The Cancer Genome Atlas (TCGA), set enrichment analysis (GSEA) was used explore...
Dobutamine, a sympathomimetic agent, is widely used clinically, influencing cardiac output, heart rate (HR), and blood pressure (BP), which may impact cerebral flow (CBF), critical for brain metabolism. However, the effects of dobutamine on CBF internal carotid artery (ICA) remain unclear, with contradictory reported in both clinical animal studies. It necessary to investigate cervical hemodynamics. This study aimed evaluate infusion ICA CBF, explore their relationship, identify factors...
The development of 5G remote robot-assisted gastrointestinal surgery is an important breakthrough in the field four-level surgery. This paper will review history robot assisted surgery, and share Gansu province people's hospital about preoperative preparation, network equipment connection,"3+2" Trocar layout, safety emergency treatment mechanism exploratory experience, for status prospect
BACKGROUND Ezrin-radixin-moesin (ERM) plays an important role in multiple links of tumors. It also involved breast cancer invasion and metastasis, might be a potential biomarker cancer. Another study suggested that ERM expression was regulated directly by miR-200c, had critical miR-200c suppressing cell migration. This aimed to investigate the effect miR-200b on line its influence metastasis ability vitro. MATERIAL AND METHODS Breast lines MCF-7 MDA-MB-231 with different metastatic...
Previous studies found that iron accumulates in the substantia nigra of Parkinson's disease patients. However, it is still unclear whether other brain regions have accumulation as well. In this experiment, rats with rotenone-induced were treated by gastric perfusion baicalin or intraperitoneal injection deferoxamine. Immunohistochemical staining demonstrated accumulated not only pars compacta, but also significantly striatum globus pallidus, dentate gyrus granular layer hippocampus,...
Abstract Background With the decline of cognitive function in vascular impairment, burden on family and society will increase. Therefore, early identification mild impairment (VaMCI) is crucial. The focus VaMCI attention risk factors. this study aimed to investigate relationship between diabetes among Chinese, hoping predict by move forward. Methods We collected data from seven clinical centers nine communities China. All participants were over 50 years age had complaints. basic information...
Exendin-4, a glucagon-like peptide-1 receptor agonist, demonstrated cytoprotective actions beyond glycemic control in recent studies. The aims of the present study were to investigate effects exendin-4 on high glucose (HG)-induced cardiomyocyte apoptosis and possible mechanisms. Rat cardiomyocytes divided into 3 groups: normal group (NG group), HG +exendin-4 (HG+Ex Group). Cardiomyocyte was evaluated by double-staining with annexin V-fluorescein isothiocyanate (FITC)/propidium iodide (PI)...
The purpose of this study was to explore the effect traditional Chinese medicine Fuyou formula on precocious puberty (PP). Fy may exert an in female rats with PP and GT-7 cells through GPR54/GnRH signaling pathway. To confirm pathway, we first treated GT1-7 observed changes expression related genes proteins GnRH secretion. Then, randomly divided young Sprague-Dawley into control group, model leuprorelin group group. A established by injection danazol postnatal day 5, administered PND15. time...
Obstructive sleep apnea syndrome (OSAS) is related to hypertension. Vascular remodeling both the pathogenesis and structural change basis of OSAS-related Exploring miRNA functioning in hypertension may offer novel diagnostic therapeutic targets for controlling hypertension-associated cardiovascular diseases. However, role miR-199a-5p has not been demonstrated yet.In this study, we investigated HIF-1α by performing vitro cell experiments vivo animal experiments. Rat aortic smooth muscle cells...
Previous studies have shown that baicalin prevented iron accumulation after substantia nigra injury, reduced divalent metal transporter 1 expression, and increased ferroportin expression in the of rotenone-induced Parkinson's disease rats. In current study, we investigated relationship between transferrin C6 cells, to explore mechanisms inhibitory effect on observed Iron content was detected using inductively coupled plasma-atomic emission spectroscopy. Results showed decreased 41% blocking...