A5100355736- Reproductive System and Pregnancy
- Autophagy in Disease and Therapy
- Pregnancy and preeclampsia studies
- Birth, Development, and Health
- Gestational Diabetes Research and Management
- Cancer-related molecular mechanisms research
- Endometriosis Research and Treatment
- Endometrial and Cervical Cancer Treatments
- Preterm Birth and Chorioamnionitis
- Pregnancy and Medication Impact
- Uterine Myomas and Treatments
- Systemic Lupus Erythematosus Research
- COVID-19 Impact on Reproduction
- Nutrition and Health in Aging
- Maternal and fetal healthcare
- Ureteral procedures and complications
- MicroRNA in disease regulation
- Sepsis Diagnosis and Treatment
- Kidney Stones and Urolithiasis Treatments
- Cardiovascular Health and Risk Factors
- Bariatric Surgery and Outcomes
- Iron Metabolism and Disorders
- Ectopic Pregnancy Diagnosis and Management
- Fuel Cells and Related Materials
- PI3K/AKT/mTOR signaling in cancer
Nanjing Drum Tower Hospital
2018-2024
Nanjing University of Chinese Medicine
2024
National Health and Family Planning Commission
2024
Peking University
2021-2024
First Hospital of Shanxi Medical University
2024
Shanxi Medical University
2023-2024
Second Xiangya Hospital of Central South University
2013-2023
Central South University
2013-2023
Weifang Medical University
2022-2023
McMaster University
2022-2023
Background Given the high prevalence of chronic kidney disease (CKD), primary care physicians (PCPs) frequently manage early stage CKD. Nonetheless, there are challenges in providing optimal CKD setting. This study sought to understand PCPs' perceptions barriers and facilitators management Study design Mixed methods Settings participants Community-based PCPs four US cities: Baltimore, MD; St. Louis, MO; Raleigh, NC San Francisco, CA. Methodology We used a self-administered questionnaire...
LncRNA PTCSC3 is a tumor suppressor in thyroid cancer, and its role drug resistance of anaplastic cancer (ATC) to chemotherapy doxorubicin was investigated this study.Expression RNA protein analyzed by qRT-PCR western blot, respectively. Flow cytometry used analyze the expression rate CD133+ cells. The endogenous related genes modulated recombinant plasmids cell transfection. Combination condition interaction between STAT3 were determined RIP pull-down assay, MTT assay performed detect...
Since it was first described in 1968, immunoglobulin (Ig)A nephropathy (IgAN) has become the most commonly diagnosed form of primary glomerular disease worldwide. A number reports have shown that toll‑like receptor 9 (TLR9) and B‑cell activating factor (BAFF) may be associated with IgAN; however, sufficient evidence not yet to delivered. In present study, serum levels BAFF as well TLR9 mRNA protein peripheral blood mononuclear cells (PBMCs) were assessed. Expression PBMCs examined by...
BackgroundRecurrent implantation failure (RIF) remains a critical and challenging problem in assisted reproductive technology mainly due to impaired decidualization. The endocytic transcytotic activity the endometrium are crucial for most representative gene is C-terminal Eps15 homology domain-containing 1 (EHD1), but whether EHD1-mediated function responsible embryo during decidualization unclear.MethodsA transcriptomic analysis was performed evaluate differentially expressed genes between...
Epithelial membrane protein 1 (EMP1), a member of the EMP family, is overexpressed in large number tumors and thought to be cellular connexin on cell involved proliferation, invasion, metastasis tumor cells, epithelial-mesenchymal transition (EMT). Nevertheless, its biomedical function ovarian cancer still unclear. EMP1 was detected lines by whole transcriptome resequencing. The mRNA examined qRT-PCR. relationship between expression clinical classification, metastasis, shortened survival...
With technological advancements, radiotherapy (RT) has become an effective non-surgical treatment for hepatocellular carcinoma (HCC), comprehensively improving the local control rate of patients with HCC. However, some HCC still experience radio-resistance, cancer recurrence, and distant metastasis following RT. Our previous study revealed that hexokinase 2 (HK2), a potent oncogene, was overexpressed in radio-resistant cell lines; however, its role radio-resistance remains elusive. Here, we...
Sex-specific influences have been shown for a variety of diseases. Whether donor or recipient sex and hormone levels impact alloimmune responses remains unclear. In unifactorial multifactorial analyses more than 400 000 SRTR listed kidney transplant patients, we found that younger female recipients had an inferior death-censored graft survival was independent sex. contrast, superior in older recipients, suggesting the hormones over chromosomal mismatches. Those clinical changes were...
AT-rich interactive domain 1A (ARID1A) is a tumor suppressor gene that encodes the BAF250a protein. Recent studies have shown loss of ARID1A expression in several types tumors. We aimed to investigate clinical and pathologic role endometrial carcinoma.We examined its correlation with p53, estrogen receptor, progesterone glucocorticoid hypoxiainduciblefactor-1α, vascular endothelial growth factor normal various malignant tissues.The BAF250 was significantly down-regulated carcinoma when...
Dendritic cells are the primary antigen-presenting that contact trophoblasts at beginning of pregnancy. Excessive DCs maturity is described in some pregnancy complications, such as pre-eclampsia and fetal growth restriction, which characterized by impaired trophoblast invasion. However, mechanism unclear. The long non-coding RNA DC (lnc-DC) expressed exclusively conventional human induces differentiation maturation promoting signal transducer activator transcription 3 (STAT3)...
Bortezomib (bort) is an effective therapeutic agent for patients with multiple myeloma (MM); however, most develop drug resistance. Autophagy, a highly conserved process that recycles cytosol or entire organelles via lysosomal activity, essential the survival, homeostasis, and resistance in MM. Growing evidence has highlighted E3 ligase tripartite motif-containing protein 21 (TRIM21) not only interacts autophagy regulators but also participates various cancers. However, to date, direct...
The common use of singleton fetal growth standard to access twin might lead over-monitoring and treatment. We aimed develop standards for Chinese twins based on ultrasound measurements, compare it with Zhang's other charts.A cohort uncomplicated pregnancies were prospectively followed in 2014-2017. Smoothed estimates percentiles both monochorionic (MC) dichorionic (DC) obtained using a linear mixed model. also created charts model-based approach proposed by Zhang et al. Our compared...
Recurrent implantation failure (RIF) caused by various etiological factors remains a challenge for fertility clinicians using assisted reproductive technology (ART) worldwide. Dysregulation of leukemia inhibitory factor (LIF) in the endometria women with RIF is involved impaired endometrial receptivity and embryo adhesion. However, mechanism through which LIF expression regulated still poorly understood. Our previous study noted that abnormally increased Krüppel-like 12 (KLF12) led to...
Background Serological tests are indispensable in the diagnosis of early infection. At present, only procalcitonin (PCT) and C‐reactive protein (CRP) commonly used clinical practice. Recently, serum amyloid A1 (SAA1) heparin binding (HBP) have been shown to be new biomarkers, because SAA1 is highly sensitive specific for viral infections, HBP predictive septic shock. In this study, PCT, CRP, HBP, were detected different combinations improve diagnostic accuracy infection using biotin‐avidin...
The impact of strabismus on visual function, self-image, self-esteem, and social interactions might decrease health-related quality life (HRQoL). This study aimed to evaluate the psychometric properties clinical applications two strabismus-specific HRQoL questionnaires in cultural context China. Chinese versions Adult Strabismus Quality Life Questionnaire (AS-20) Amblyopia (ASQE) were self-administered 304 adults with strabismus. Cronbach's α coefficient was calculated assess internal...