A5101720108- Metabolomics and Mass Spectrometry Studies
- Traditional Chinese Medicine Analysis
- Natural product bioactivities and synthesis
- Microbial Natural Products and Biosynthesis
- Phytochemistry and Biological Activities
- Ginseng Biological Effects and Applications
- Fungal Biology and Applications
- Tryptophan and brain disorders
- Gut microbiota and health
- Pharmacological Effects of Natural Compounds
- Phytochemistry and Bioactive Compounds
- Essential Oils and Antimicrobial Activity
- Streptococcal Infections and Treatments
- Wood and Agarwood Research
- Cultural Heritage Materials Analysis
- Neonatal and Maternal Infections
- Diet and metabolism studies
- Traditional Chinese Medicine Studies
- Antimicrobial Resistance in Staphylococcus
- Microbial Metabolism and Applications
- Sphingolipid Metabolism and Signaling
- Plant Pathogens and Fungal Diseases
- Phytochemicals and Medicinal Plants
- Liver Disease Diagnosis and Treatment
- Phytochemical Studies and Bioactivities
Chinese Academy of Medical Sciences & Peking Union Medical College
2015-2024
State Administration of Traditional Chinese Medicine of the People's Republic of China
2021-2024
Guangzhou University of Chinese Medicine
2024
First Affiliated Hospital of Jinan University
2024
Peking Union Medical College Hospital
2016-2020
Institute of Medicinal Plant Development
2016-2019
Heilongjiang Bayi Agricultural University
2015
Jinan University
2013
Xinjiang University
2006-2009
Emerging evidence highlights the role of gut microbiota in regulating pathogenesis coronary heart disease. Here, we performed 16S rRNA gene sequencing and UPLC-Q-TOF/MS-based metabolomics to investigate microbiome metabolomes cecal contents isoproterenol (ISO)-induced acute myocardial ischemia (AMI) rats. As expected, considerable alterations were observed AMI rats compared with control rats, paralleling intestinal inflammation apoptosis. At phylum level, abundance Firmicutes was...
A pair of coumarin-based polycyclic meroterpenoid enantiomers (+)/(−)-gerbeloid [(+)-1a and (−)-1b] were isolated from the medicinal plant Gerbera piloselloides, which have a unique caged oxatricyclo [4.2.2.03,8] decene scaffold. Their planar three-dimensional structures exhaustively characterized by comprehensive spectroscopic data X-ray diffraction analysis. Guided hypothetical biosynthetic pathway, biomimetic synthesis racemic 1 was achieved using 4-hydroxy-5-methylcoumarin citral as...
Abstract Depression is a complex disease characterized by series of pathological changes. Research on depression mainly focused the changes in brain, but not liver. Therefore, we initially explored metabolic profiles hepatic extracts from rats treated with chronic unpredictive mild stress (CUMS) UPLC-Q-TOF/MS. Using multivariate statistical analysis, total 26 altered metabolites distinguishing CUMS-induced normal control were identified. two-stage receiver operating characteristic (ROC) 18...
<italic>Flos Chrysanthemi Indici</italic> (FCI), is a common functional food for the treatment of inflammatory diseases. UPLC-MS/MS and network pharmacology were combined to investigate comprehensive chemical profile FCI with anti-inflammatory effect.
Abstract Accumulating evidence suggests that the gut microbiota dysbiosis and their host metabolic phenotype alteration is an important factor in human disease development. A traditional Chinese herbal formula, Chaihu-Shu-Gan-San (CSGS), has been effectively used treatment of various gastrointestinal (GI) disorders. The present study was carried out to investigate whether CSGS modulates under condition dysbiosis. metabonomics studies biochemical changes urine feces antibiotic-induced rats...
This study first reports the metabolic variations at early stage of liver injury related to autoimmune hepatitis.
Overexpression of laeA in Chaetomium globosum CBS148.51 up-regulated expression the chaetoglobosin gene cluster and resulted isolation a new cytochalasan, Z (1), together with six known analogues, chaetoglobosins A (2), B (3), D (4), E (5), O (6), V (7). RT-PCR analysis confirmed that key genes were significantly up-regulated. The structure compound (1) was elucidated using NMR data. relative absolute configurations determined by NOESY electronic circular dichroism combined quantum-chemical...
Wild Chi-Nan agarwood is regarded as the highest quality from Aquilaria spp. However, comprehensive research on chemical composition of wild limited. An integrated strategy using SHS-GC-MS and UPLC-Q/Tof-MS was applied to explore phytochemical characteristics a kind induced newly identified germplasm A. sinensis. Progenesis QI MS-Dial were used preprocess GC-MS raw data, respectively. Principle component analysis (PCA) orthogonal partial least squares latent structure-discriminant (OPLS-DA)...
Asthma is a chronic inflammatory disorder of the airway and characterized by remodeling, hyperresponsiveness, shortness breath. Modified Kushen Gancao Formula (mKG), derived from traditional Chinese herbal medicines (TCM), has been demonstrated to have good therapeutic effects on experimental allergic asthma. However, its anti-asthma mechanism remains currently unknown. In present work, metabolomics studies biochemical changes in lung tissue plasma ovalbumin (OVA)-induced asthma mice with...
The health-promoting benefits of medicine and food homology (MFH) are known for thousands years in China. However, active compounds biological mechanisms unclear, greatly limiting clinical practice MFH. advent gut microbiota analysis metabolomics emerge as key tools to discover functional compounds, therapeutic targets, Such studies hold great promise promote optimize efficacy development MFH-based products, example, foods daily dietary supplements or special medical purposes. In this...
Pulmonary fibrosis (PF) is a serious progressive lung disease and it originates from inflammation-induced parenchymal injury with excessive extracellular matrix deposition to result in the destruction of normal architecture. Modified Kushen Gancao Formula (mKG), derived traditional Chinese herbal medicine, has prominent anti-inflammatory effect. The present study explore inhibitory effects mKG on bleomycin (BLM)-induced pulmonary mice. significantly decreased alveolitis, scores,...
Trematosphones A (1) and B (2), two unique dimers with novel structural features, were isolated from the special bioenvironmental desert plant endophytic fungus Trematosphaeria terricola. Their structures assigned on basis of spectroscopic approaches including NMR, calculated electronic circular dichroism data, X-ray diffraction analysis. Possible biosynthetic pathways these compounds proposed. Trematosphone exhibited protective activities against corticosterone-induced damages in PC12.