A5101525572- Pain Mechanisms and Treatments
- Immune cells in cancer
- Hormonal and reproductive studies
- Neuropeptides and Animal Physiology
- Immune Response and Inflammation
- Urinary and Genital Oncology Studies
- Parkinson's Disease Mechanisms and Treatments
- Medicinal Plants and Neuroprotection
- Folate and B Vitamins Research
- Receptor Mechanisms and Signaling
- Biochemical Analysis and Sensing Techniques
- Regulation of Appetite and Obesity
- Healthcare and Venom Research
- Liver Disease Diagnosis and Treatment
- Viral Infections and Immunology Research
- Cancer Treatment and Pharmacology
- Coronary Interventions and Diagnostics
- Ion Channels and Receptors
- Ziziphus Jujuba Studies and Applications
- Alzheimer's disease research and treatments
- Autoimmune and Inflammatory Disorders Research
- Neutropenia and Cancer Infections
- interferon and immune responses
- Selenium in Biological Systems
- Muscle metabolism and nutrition
Zhujiang Hospital
2024
Heilongjiang Provincial Academy of Agricultural Sciences
2023
Nanjing University of Science and Technology
2020-2023
Affiliated Hospital of Qingdao University
2015-2022
Qingdao University
2012-2022
Nanjing University of Chinese Medicine
2018-2021
Auburn University
2014-2020
Xingtai Medical College
2020
Xingtai People's Hospital
2020
Hebei Medical University
2020
Enterovirus-induced myocardial injury can lead to severe heart failure. To date, little is known about the early innate stress response that contributes host defense in heart. Toll-like receptor 3 (TLR3) important initiation of antiviral response. We investigated involvement TLR3, which recognizes viral double-stranded RNA, on encephalomyocarditis virus (EMCV) infection. examine contribution TLR3 protection from EMCV infection, we infected mice deficient with 50 plaque-forming units EMCV....
Apolipoprotein (apo) C-III plays a regulatory role in VLDL lipolysis and clearance. In this study, we determined potential intracellular of apoC-III hepatic assembly secretion. Stable expression recombinant McA-RH7777 cells resulted increased secretion efficiency VLDL-associated triacylglycerol (TAG) apoB-100 gene-dosage-dependent manner. The stimulatory effect on TAG was manifested only when were cultured under lipid-rich (i.e., media supplemented with exogenous oleate) but not lipid-poor...
Impaired hepatic phosphatidylcholine (PC) synthesis lowers plasma lipids. We, therefore, tested the hypothesis that lack of phosphatidylethanolamine N-methyltransferase (PEMT), a enzyme catalyzing PC biosynthesis, attenuates development atherosclerosis.Mice deficient in both PEMT and low-density lipoprotein receptors (Pemt(-/-)/Ldlr(-/-) mice) were fed high-fat/high-cholesterol diet for 16 weeks. Atherosclerotic lesion area was approximately 80% lower (P<0.01) Pemt(-/-)/Ldlr(-/-) mice than...
In-Stent Restenosis (ISR) is the major reason for recurrent ischemia and amputation after endovascular treatment of Peripheral Artery Disease (PAD). Our previous study demonstrated that miR-140-3p significantly down-regulated in PAD arteries. However, expression function ISR human are currently unclear.The aim this to determine its regulative role PAD.The RNA level was determined by quantitative real-time polymerase chain Reaction (qRT-PCR) situ hybridization. Primary cultured ASMCs were...
Pulmonary fibrosis (PF) is a serious progressive lung disease and it originates from inflammation-induced parenchymal injury with excessive extracellular matrix deposition to result in the destruction of normal architecture. Modified Kushen Gancao Formula (mKG), derived traditional Chinese herbal medicine, has prominent anti-inflammatory effect. The present study explore inhibitory effects mKG on bleomycin (BLM)-induced pulmonary mice. significantly decreased alveolitis, scores,...
Selenium (Se) is an important trace element in human and animal health. Approximately 0.5–1 billion people worldwide are facing Se deficiency which can result various endemic diseases. Cabbage one of the most popular vegetables accumulate through biofortification. Therefore, producing Se-enriched cabbage may be effective method to alleviate deficiency. In this study, effects different concentrations selenite application on growth nutritional quality were investigated results showed that was...
Melanocortin 4 receptor (MC4R) is implicated in the initiation and maintenance of neuropathic pain. Although effect MC4R on pain known, it remains unclear how mediates In vitro activates mitogen-activated kinase (MAPK). Accordingly, we investigate whether p38MAPK cascade vivo to trigger behavior Wistar rats after chronic constriction injury (CCI). Intrathecal injection antagonist HS014 (5 μg/day) at moment CCI for seven days attenuated thermal hyperalgesia mechanical allodynia. Similarly,...
Background: Neuropathic pain is characterised by spontaneous ongoing or shooting and evoked amplified responses after noxious non-noxious stimuli. develops as a result of lesions disease affecting the somatosensory nervous system either in periphery centrally. Melanocortin 4 receptor (MC4R) plays an important role initiation neuropathic but underlying mechanisms are still unclear. Methods: Adult male Wistar rats were given chronic constriction injury (CCI) sham operations. Part CCI...
Background: Neuropathic pain can develop after nerve injury, when deleterious changes occur in injured neurons and glia cells. Melanocortin 4 receptor (MC4R) was involved the regulation of due to its high expressions brain. Moreover, MC4R could mediate c-Jun N-terminal kinase (JNK) signaling pathway, but whether MC4R-regulated JNK pathway participated neuropathic chronic constriction injury (CCI) is still unclear. Methods: 128 Sprague-Dawley rats were allocated into experiment groups: SHAM...
It is well known that Alzheimer's disease (AD) a progressive neurodegenerative characterized by memory deficits and cognitive decline. Amyloid-β (Aβ) deposition synaptic dysfunction play important roles in the pathophysiology of (AD). The Huatuo Zaizao pill (HT) Traditional Chinese Medicine (TCM) has been used clinically for many years China, mainly post-stroke rehabilitation decline; however, mechanism function not clear. In this study, we investigated effect HT on hippocampal function,...
The aim of the study is to compare effects exercise therapy with chondroitin sulfate (CS) in an experimental model osteoarthritis (OA). Twenty-one New Zealand rabbits were randomly divided into four groups: normal group (N group, n = 3); OA control (C 6); plus medication (CS and (E 6). Four weeks after modeling, subjected (artificial, 30 min/time, 4 times/week) or medicated CS (2% CS, 0.3 ml/time, once/week) for weeks. Histopathological changes treated joints examined staining. X-ray...
Breast cancer is one of the most common malignancies in women. Neoadjuvant trastuzumab therapy improves prognosis certain Her‑2‑positive breast patients, however around two‑thirds patients with do not benefit from Her‑2‑targeted therapy. To investigate key mechanisms resistance, potential biomarkers for neoadjuvant sensitivity were investigated using gene expression omnibus (GEO) database mRNA microarray data who received GEO profiles 22 a complete response and 48 partial identified...
Purpose: Neuropathic pain is a chronic intractable disease characterized by allodynia and hyperalgesia. Effective treatments are unavailable because of the complicated mechanisms neuropathic pain. Transient receptor potential canonical 6 (TRPC6) nonselective calcium (Ca 2+ )-channel protein related to Dexmedetomidine (Dex) an alpha-2 (α 2) adrenoreceptor agonist that mediates intracellular Ca levels alleviate However, relationship between TRPC6 Dex currently unclear. We speculated α 2 would...
Abstract Overweight and obese men face numerous health problems, including type 2 diabetes, subfertility, even infertility. However, few studies have focused on the effects of nutritional status obesity‐related regulatory signals fertility deficiency. Our previous observations shown that elevation plasma 5'‐adenosine monophosphate (5'‐AMP) accumulation adenosine in liver muscle diabetic db / mice are related to insulin resistance. Here, we found testis is a common marker both genetic obesity...
Renal ischemia-reperfusion injury is a major trigger of acute kidney and leads to permanent renal impairment, effective therapies remain unresolved. Riclinoctaose an immunomodulatory octasaccharide composed glucose galactose monomers. Here we investigated whether riclinoctaose protects against injury. In mice, pretreatment with significantly improved function, structure, the inflammatory response after ischemia-reperfusion. Flow cytometry analysis revealed that inhibited...
Parkinson's disease (PD), the typical neurodegenerative disease, is characterized by progressive loss of dopaminergic neurons in substantia nigra (SN). However, no therapeutic agent used currently could slow down neuronal cell so as to decelerate or halt progression PD. Traditional Chinese medicine (TCM) has been utilized treat dysfunction autonomic nervous system. Wen-Shen-Yang-Gan decoction (WSYGD) a good effect on clinical treatment PD with constipation. it not clear which ingredients and...
This study aimed to explore the protective effects of Wenshen-Yanggan decoction on dopaminergic (DA) neuron injury in a rotenone‐induced mouse model with chronic Parkinson’s disease (PD) and its mechanism action. Ultraperformance liquid chromatography‐tandem mass spectrometry (UPLC‐MS/MS) was used measure content six main components decoction. The PD established by treating 10‐month‐old healthy wild C57BL/6 male mice rotenone 30 mg/kg/day for 28 days succession. pole test rotarod were...