A5101833600- Coagulation, Bradykinin, Polyphosphates, and Angioedema
- Autoimmune Bullous Skin Diseases
- Urticaria and Related Conditions
- Cancer-related molecular mechanisms research
- Uterine Myomas and Treatments
- Genetics and Neurodevelopmental Disorders
- Corneal surgery and disorders
- Urinary and Genital Oncology Studies
- Cancer Cells and Metastasis
- Dermatological and Skeletal Disorders
- Renal and related cancers
- Ocular Surface and Contact Lens
- Glycosylation and Glycoproteins Research
- Mesenchymal stem cell research
- Gynecological conditions and treatments
- Endometrial and Cervical Cancer Treatments
- Circular RNAs in diseases
- Teratomas and Epidermoid Cysts
- Heavy Metal Exposure and Toxicity
- melanin and skin pigmentation
- Veterinary Pharmacology and Anesthesia
- Endometriosis Research and Treatment
- Xenotransplantation and immune response
- RNA regulation and disease
- Cervical Cancer and HPV Research
Taizhou People's Hospital
2014-2024
Nantong University
2014-2024
Hunan University
2024
Nanchang University
2021-2024
Nanjing Medical University
2022-2024
Heilongjiang Provincial Academy of Agricultural Sciences
2023
Dalian Medical University
2023
Dalian University
2023
Jiangxi Chest Hospital
2022
Second Hospital of Shandong University
2021
Selenium (Se) is an important trace element in human and animal health. Approximately 0.5–1 billion people worldwide are facing Se deficiency which can result various endemic diseases. Cabbage one of the most popular vegetables accumulate through biofortification. Therefore, producing Se-enriched cabbage may be effective method to alleviate deficiency. In this study, effects different concentrations selenite application on growth nutritional quality were investigated results showed that was...
Waardenburg syndrome (WS) is a genetic disorder characterized by hearing loss and pigmentary abnormalities with variable penetrance. Though heterozygous mutations in MITF are major cause for type 2 (WS2), homozygous this gene the associated phenotype have been rarely characterized. In study, we identified novel p.R223H mutation Chinese Han family WS features. Both parents carried mutation. They had normal hearing, premature greying of hair their only abnormality. contrast, two children both...
BackgroundCorneal neovascularization (angiogenesis and lymphangiogenesis) compromises corneal transparency transplant survival, however, the molecular mechanisms of host epithelial stromal cells in have not yet been fully elucidated. Furthermore, contribution mechanism endothelial involved are largely unexplored.MethodsLiquid chromatography-mass spectrometry, immunoblotting, ELISA were used to screen identify potential neovascularization-related factors human full-thickness vascularized...
A remarkable shift in Mesenchymal stromal cells (MSCs) plays an important role cancer metastasis, but the molecular mechanism is still unclear. CPNE7, a calcium-dependent phospholipid-binding protein, mediates signal transduction and metastasis many tumours. Here, we demonstrated that MSCs derived from OSCC (OSCC-MSCs) promoted of by transwell assay animal models through epithelial to mesenchymal transition (EMT) (p < 0.05). RNA-sequencing, ELISA, neutralizing antibody CXCR2 inhibitor...
Abstract Human papillomavirus (HPV) infection is the leading cause of cervical cancer and precancerous lesions. Knowledge regarding prevalence genotype distribution HPV in women important to establish strategies for screening vaccination. This study aimed evaluate characteristics Taizhou, China. 10,733 who visited Taizhou People's Hospital from November 2016 October 2018 was determined using a PCR hybridization-based detection test. The overall, high risk (HR), low (LR) infections 34.58%,...
Somatic mutations in mediator complex subunit 12 (MED12) have emerged as a critical genetic change the development of uterine leiomyomas. Studies, however, focused largely on cohorts consisting Caucasian patients. In this study, leiomyomas from Chinese patients were examined for MED12 mutations. addition, polymerase chain reaction (PCR)-based high-resolution melting analysis (HRMA) was compared with direct sequencing potentially more sensitive method detection mutations.Tissue samples...
Mucous membrane pemphigoid (MMP) is a type of subepithelial autoimmune bullous disease, affecting various mucosae, occasionally with skin lesions. Both diagnosis and treatment MMP are difficult. Although multiple autoantigens have been identified for MMP, the pathogenesis still unclear. In this study, we presented female case extensive oral mucosal lesions lesions, particularly on extremities. IgG IgA autoantibodies against including BP180, laminin 332, integrinα6β4 desmoglein 3, IgM BP180...
RNase P ribozyme can be engineered to a sequence-specific gene-targeting agent with promising application in both basic research and clinical settings. By using an vitro selection system, we have previously generated variants that better catalytic activity cleaving mRNA sequence than the wild type ribozyme. In this study, one of was used target encoding human cytomegalovirus (HCMV) essential transcription factor immediate-early protein 2 (IE2). The variant able cleave IE2 50-fold A reduction...
Autoimmune bullous diseases (AIBDs), presenting cutaneous and/or mucosal lesions, are classified into pemphigus and pemphigoid diseases. A longtime observation for complicated AIBD cases is rarely reported. In this study, serum samples of one patient were collected at seven different time points during the disease course including a relapse, which examined by our conventional newly developed methods detection autoantibodies. Interestingly, we found changes both presence titers various...
: Ocular predominant mucous membrane pemphigoid (oMMP) is a severe subtype of autoimmune blistering disease (AIBD), which can result in scarring and vision loss. The diagnosis oMMP challenging as patients often have undetectable levels circulating autoantibodies by conventional assays. Likewise, the principal autoantigen has been an area debate.
Abstract Background Long non-coding RNAs (lncRNAs) and microRNAs (miRNAs) were reported to be aberrantly expressed related the pathogenesis of ovarian cancer. However, role regulatory mechanism MSC-AS1 in cancer has yet fully elucidated. Methods Expression lncRNA (MSC-AS1) microRNA-425-5p (miR-425-5p) tissue samples cell lines was examined by quantitative real-time polymerase chain reaction (qRT-PCR). The functions on proliferation, cycle apoptosis determined using MTT, colony formation flow...
To provide prenatal diagnosis for a pregnant woman with genetic history of intellectual disability.A Chinese pedigree disability was collected in this study. Cytogenetic analysis, chromosomal microarray analysis (CMA) and whole exome sequencing (WES) followed by Sanger validation were conducted to identify the pathogenesis. A novel heterozygous deletion c.370_374delTTCCC TBR1 gene identified, leading frameshift mutation starting at Phe124 premature stop codon position 141 (p.Phe124Valfs∗18)....