A5017968924- Nerve injury and regeneration
- Spinal Cord Injury Research
- Neurogenesis and neuroplasticity mechanisms
- Mesenchymal stem cell research
- Nerve Injury and Rehabilitation
- Neuroinflammation and Neurodegeneration Mechanisms
- Tissue Engineering and Regenerative Medicine
- Stroke Rehabilitation and Recovery
- Coagulation, Bradykinin, Polyphosphates, and Angioedema
- Cerebral Palsy and Movement Disorders
- Lung Cancer Diagnosis and Treatment
- Neurological Disease Mechanisms and Treatments
- Alzheimer's disease research and treatments
- Neuroscience and Neuropharmacology Research
- Hepatocellular Carcinoma Treatment and Prognosis
- Neurogenetic and Muscular Disorders Research
- Periodontal Regeneration and Treatments
- Intracerebral and Subarachnoid Hemorrhage Research
- Breast Cancer Treatment Studies
- Vascular Tumors and Angiosarcomas
- Autophagy in Disease and Therapy
- Spondyloarthritis Studies and Treatments
- Cholinesterase and Neurodegenerative Diseases
- Neonatal and Maternal Infections
- Preterm Birth and Chorioamnionitis
Beihang University
2009-2025
Beijing United Family Hospital
2025
Capital Medical University
2009-2024
State Key Laboratory of Oncogene and Related Genes
2022
Shanghai Jiao Tong University
2021-2022
Nanchang University
2022
Chinese Academy of Medical Sciences & Peking Union Medical College
2009-2021
Beijing Advanced Sciences and Innovation Center
2021
Shanghai Ninth People's Hospital
2021
Peking Union Medical College Hospital
2009-2020
Significance Spinal cord injury (SCI) is a debilitating medical condition with no cure at present time. In this study we have discovered that biodegradable material, chitosan, when loaded with, Neurotrophin-3 (NT3), allowed for slow release of neural trophic factor, providing an optimal microenvironment regeneration. NT3-chitosan, inserted into 5 mm gap completely transected and excised rat thoracic spinal cord, elicited robust activation endogenous stem cells forming functional networks,...
Significance Spinal cord injury (SCI) is a severe medical condition often leading to permanent loss of sensory, motor, and autonomic functions, currently with no cure. This study provides evidence that in monkeys SCI, bioactive biodegradable material, NT3-chitosan, elicited robust de novo neural regeneration including, for example, long-distance axonal growth cortical motor neurons the spinal tract, as well sensory functional recovery. In this study, we utilized battery minimally invasive...
Spinal cord injury (SCI) is considered incurable because axonal regeneration in the central nervous system (CNS) extremely challenging, due to harsh CNS environment and weak intrinsic capability of neurons. We discovered that neurotrophin-3 (NT3)-loaded chitosan provided an excellent microenvironment facilitate nerve growth, new neurogenesis, functional recovery completely transected spinal rats. To acquire mechanistic insight, we conducted a series comprehensive transcriptome analyses...
Object A glial scar is thought to be responsible for halting neuroregeneration following spinal cord injury (SCI). However, little quantitative evidence has been provided show the relationship of a and axonal regrowth after injury. Methods In this study performed in rats dogs, traumatic SCI model was made using weight-drop device, tissue sections were stained with H & E immunohistochemical analysis. The function behavior animals tested electrophysiological recording...
Adenomyosis, typically associated with heavy menstrual bleeding and pelvic pain, is rarely linked to neurological complications. This case presents a rare instance of ischemic stroke in young patient adenomyosis vascular abnormalities, underscoring the role anemia, hypercoagulability, factors as potential contributors cerebral infarction. We describe 41-year-old female history who presented right-sided hemianopia dizziness following severe bleeding. Imaging revealed multiple acute...
Assessing residual motor function in complete spinal cord injury (SCI) patients using surface electromyography (sEMG) is clinically important. Due to the prolonged loss of control and peripheral sensory input, may struggle effectively activate during sEMG assessments. The study proposes virtual reality (VR) technology enhance embodiment, imagery (MI), memory, aiming improve activation increase sensitivity By Recruiting a sample 12 with AIS A/B capturing electromyographic signals before,...
The surface growth mode can induce the anomalous compressive strain in thicker VO<sub>2</sub>/Al<sub>2</sub>O<sub>3</sub> epitaxial films, which can't be explained by conventional lattice-mismatch. Strain may an effective tool for manipulating MIT of VO<sub>2</sub> films.
Attempts have been made to use cell transplantation and biomaterials promote proliferation, differentiation, migration, survival, as well angiogenesis, in the context of brain injury. However, whether bioactive materials can repair damage caused by ischemic stroke activating endogenous neurogenesis angiogenesis is still unknown. In this study, we applied chitosan gel loaded with basic fibroblast growth factor cavity 7 days after rats. The slowly released factor, which improved local...
Head and neck squamous cell carcinoma (HNSCC), one of the most common malignancies worldwide, often has a poor prognosis due to associated metastasis chemoresistance. Hence, development more effective chemotherapeutics is critical. Neferine, bisbenzylisoquinoline alkaloid isolated from seed embryo Nelumbo nucifera (common name: Lotus), exerts antitumor effects by regulating apoptosis autophagy pathways, making it potential therapeutic option for HNSCC. In our study, was revealed that...
Objective: Effective biomarkers for early detection of ovarian cancer are needed.Our study previously showed that basement membrane protein, nidogen-1 plasma level was significantly increased in patients.This aimed to examine the levels a large patient population evaluate its effectiveness serous carcinoma and expression tumor tissues.Methods: The concentration circulating specimens 265 patients 98 healthy individuals were assayed by enzyme linked immunosorbent assay.The medical records...
Community-acquired pneumonia is a common illness worldwide. In adults, community-acquired bacterial has been well studied, but viral less understood. We designed this study to identify respiratory pathogens, including pneumonia-causing bacteria, viruses and atypical using reverse transcription-polymerase chain reaction.We conducted retrospective of outpatients with at the Fever Clinic Peking University Third Hospital. collected sputum or throat swabs from patients diagnosed pneumonia....
Neural circuit reconstruction is the main target of functional restoration after adult spinal cord injury (SCI). The microenvironment SCI hostile to neural regeneration. Here, we designed a bFGF controlled releasing system (bFGF-CRS) by loading onto sodium hyaluronate collagen scaffolds modify microenvironment. We found that bFGF-CRS had proper mechanical properties for regeneration and could slowly release up 6 weeks under physiological condition. After implantation, reduce microglial...
Objectives To develop effective nomograms for predicting pneumothorax and delayed after microwave ablation (MWA) in lung malignancy (LM) patients.Methods LM patients treated with MWA were randomly allocated to a training or validation cohort at ratio of 7:3. The predictors identified by univariate multivariate analyses the used predictive nomogram. C-statistic was evaluate accuracy both cohorts. A second nomogram developed validated using identical methods.Results total 552 (training cohort:...
Primary hepatic angiosarcoma (PHA) is a rare and aggressive solid tumor, with high rates of local recurrence distant metastasis, poor prognosis. There are no established treatment guidelines for PHA. A 78-year-old asymptomatic man PHA that was successfully treated pazopanib plus PD-1 inhibitor RetroNectin-activated killer cells (RAK cells). After one month treatment, there clear reduction in the size number liver metastases; after nearly 15 months, most lesions were stable, new had...
Abstract JOURNAL/nrgr/04.03/01300535-202403000-00039/inline-graphic1/v/2023-09-27T141015Z/r/image-tiff Stroke can cause Wallerian degeneration in regions outside of the brain, particularly corticospinal tract. To investigate fate major glial cells and axons within affected areas tract following stroke, we induced photochemical infarction sensorimotor cortex leading to along full extent We first used a routine, sensitive marker axonal injury, amyloid precursor protein, examine An antibody...
JOURNAL/nrgr/04.03/01300535-202508000-00024/figure1/v/2024-09-30T120553Z/r/image-tiff Patients with complete spinal cord injury retain the potential for volitional muscle activity in muscles located below level. However, because of prolonged inactivity, initial attempts to activate these may not effectively engage any remaining neurons descending pathway. A previous study unexpectedly found that a brief clinical round passive significantly increased activation, as measured by surface...
JOURNAL/nrgr/04.03/01300535-202510000-00024/figure1/v/2024-11-26T163120Z/r/image-tiff The presence of endogenous neural stem/progenitor cells in the adult mammalian brain suggests that central nervous system can be repaired and regenerated after injury. However, whether it is possible to stimulate neurogenesis reconstruct cortical layers II VI non-neurogenic regions, such as cortex, remains unknown. In this study, we implanted a hyaluronic acid collagen gel loaded with basic fibroblast...
The purpose of this study was to assess the pathological variation in white matter tracts adult severe thoracic contusion spinal cord injury (SCI) rat models combined with vivo magnetic resonance imaging (MRI), as well effect spared (WM) quantity on hindlimb motor function recovery. 7.0T MRI conducted for all experimental animals before SCI and 1, 3, 7, 14 days after SCI. tract different regions examined by luxol fast blue (LFB) staining, NF200 immunochemistry, diffusion tensor (DTI)...