A5014621110- Nerve injury and regeneration
- Neurogenesis and neuroplasticity mechanisms
- Spinal Cord Injury Research
- Tissue Engineering and Regenerative Medicine
- Mesenchymal stem cell research
- Urinary Bladder and Prostate Research
- Neuroscience and Neural Engineering
- Neuroscience of respiration and sleep
- Nerve Injury and Rehabilitation
- Urological Disorders and Treatments
- Anesthesia and Neurotoxicity Research
- Pluripotent Stem Cells Research
- Lung Cancer Diagnosis and Treatment
- Traumatic Brain Injury Research
- Electrospun Nanofibers in Biomedical Applications
- Genetic Neurodegenerative Diseases
- Tracheal and airway disorders
- Macrophage Migration Inhibitory Factor
- Spinal Dysraphism and Malformations
- Hernia repair and management
- Wound Healing and Treatments
- Neonatal and fetal brain pathology
- Diagnosis and treatment of tuberculosis
- Chronic Myeloid Leukemia Treatments
- Muscle Physiology and Disorders
Capital Medical University
2016-2025
Southern University of Science and Technology
2023-2024
Beijing Chao-Yang Hospital
2022-2024
Beihang University
2018
Abstract Spinal cord injury (SCI) is a severe damage usually leading to limb dysesthesia, motor dysfunction, and other physiological disability. We have previously shown that NT3-chitosan could trigger an acute SCI repairment in rats non-human primates. Due the negative effect of inhibitory molecules glial scar on axonal regeneration, however, role treatment chronic remains unclear. Compared with fresh wound SCI, how handle lesion core scars major issue related chronic-SCI repair. Here we...
Abstract Tumor-associated macrophages (TAMs) are highly heterogeneous and play vital roles in tumor progression. Here we adopted a C57BL/6 mouse model imitating the late-stage colorectal liver metastasis (CRLM) by Mc38 cancer cell injection via portal vein. With serial sections of CRLM biopsies, defined 7–9 days post-injection as critical period for neovascularization, which was initiated from innate vessels vessel cooption extended vascular mimicry thereof growth CD34 + cells. In samples...
An implanted neurotrophin-3 (NT3)-chitosan scaffold can recruit endogenous neural stem cells to migrate a lesion region and differentiate into mature neurons after adult spinal cord injury (SCI). However, the identities of these newborn whether they form functional synapses circuits promote recovery paraplegia remain unknown. By using combined advanced technologies, we revealed here that several subtypes received synaptic input from corticospinal tract (CST), rubrospinal (RST), supraspinal...
Attempts have been made to use cell transplantation and biomaterials promote proliferation, differentiation, migration, survival, as well angiogenesis, in the context of brain injury. However, whether bioactive materials can repair damage caused by ischemic stroke activating endogenous neurogenesis angiogenesis is still unknown. In this study, we applied chitosan gel loaded with basic fibroblast growth factor cavity 7 days after rats. The slowly released factor, which improved local...
Although autogenous nerve transplantation is the gold standard for treating peripheral defects of considerable length, it still has some shortcomings, such as insufficient donors and secondary injury. Composite chitosan scaffolds loaded with controlled release growth factor can promote neuronal survival axonal regeneration after short-segment sciatic defects. However, effects on extended remain poorly understood. In this study, we used 8 weeks to repair long-segment (20 mm) in adult rats....
Neural circuit reconstruction is the main target of functional restoration after adult spinal cord injury (SCI). The microenvironment SCI hostile to neural regeneration. Here, we designed a bFGF controlled releasing system (bFGF-CRS) by loading onto sodium hyaluronate collagen scaffolds modify microenvironment. We found that bFGF-CRS had proper mechanical properties for regeneration and could slowly release up 6 weeks under physiological condition. After implantation, reduce microglial...
Activation of endogenous neurogenesis by bioactive materials enables restoration sensory/motor function after complete spinal cord injury (SCI) via formation new relay neural circuits. The underlying wiring logic newborn neurons in adult central nervous system (CNS) is unknown. Here, we report neurotrophin3-loaded chitosan biomaterial substantially recovered bladder SCI. Multiple neuro-circuitry tracing technologies using pseudorabies virus (PRV), rabies (RV), and anterograde...
Bone marrow mesenchymal stem cells undergo differentiation to different lineages with efficiencies when induced by factors. We added a bFGF-chitosan controlled release system (bFGF-CCRS) as an inducer into conditioned medium facilitate the oriented of BMSCs neural lineage (eventually mature neurons); furthermore, we synchronized G0/G1 phase via serum starvation observe effect on direction and efficiency. The nonsynchronized group, chitosan alone (not loaded bFGF) soluble bFGF group served...
The purpose of this study was to assess the pathological variation in white matter tracts adult severe thoracic contusion spinal cord injury (SCI) rat models combined with vivo magnetic resonance imaging (MRI), as well effect spared (WM) quantity on hindlimb motor function recovery. 7.0T MRI conducted for all experimental animals before SCI and 1, 3, 7, 14 days after SCI. tract different regions examined by luxol fast blue (LFB) staining, NF200 immunochemistry, diffusion tensor (DTI)...
In this article, we reported a 28-year-old female patient who presented with intermittent hemoptysis, cough, and sputum production. Laboratory tests showed no abnormalities in the blood counts or inflammatory markers, cultures were negative. A chest computed tomography scan bronchiectasis associated infection middle lower lobes of right lung pleural thickening. We performed bronchoalveolar lavage by bronchoscopy dorsal segment lobe found Mycobacterium avium intracellulare complex (MAC) Next...
JOURNAL/nrgr/04.03/01300535-202510000-00024/figure1/v/2024-11-26T163120Z/r/image-tiff The presence of endogenous neural stem/progenitor cells in the adult mammalian brain suggests that central nervous system can be repaired and regenerated after injury. However, whether it is possible to stimulate neurogenesis reconstruct cortical layers II VI non-neurogenic regions, such as cortex, remains unknown. In this study, we implanted a hyaluronic acid collagen gel loaded with basic fibroblast...
Different types of traumatic brain injury (TBI) have posed a hazard to human health for while, and their aftereffects significant negative impact on patients' quality life. Despite the increased attention that TBI has received recently, clinical treatment plan is currently in place only consists palliative therapy neuroprotection or mitigation secondary injury, which minimally positive prognosis life patients. After TBI, regenerative seeks improve patient's function. Cell therapy, become one...
The repair of peripheral nerve injury is still a great challenge in clinic. Autologous transplantation the gold standard for treatment long-distance defects, but this method remains associated with high morbidity donor site and lack matching donor. In study, novel chitosan scaffold (CS) loaded control-released basic fibroblast growth factor (bFGF) was used to 20 mm sciatic defects adult rat. ultrastructure bFGF-CS observed by scanning electron microscope. tensile tester nano-indentation were...
Muscle spindles, an important proprioceptor scattered in the skeletal muscle, participate maintaining muscle tension and fine regulation of random movement. Although spindles exist all muscles, explanations about distribution morphology remain lacking for indetermination spindle location across muscles. In this study, traditional time-consuming histochemical technology was utilized to determine anatomical morphological characteristics lower extremity C57BL/6 mice. The relative distance from...
A 64-year-old female patient was admitted to Beijing Chao-Yang Hospital on February 21, 2023 because of right-sided chest pain for more than 4 years and left-sided 9 months. She had a past medical history previous tuberculosis rheumatoid arthritis. CT in October 2018 revealed multiple pulmonary nodules. CT-guided biopsy showed no tumors, adenosine deaminase levels the pleural effusion were elevated, suggesting high likelihood tuberculosis. As result, anti-tuberculosis treatment initiated...