A5004361828- Pituitary Gland Disorders and Treatments
- Growth Hormone and Insulin-like Growth Factors
- Adrenal and Paraganglionic Tumors
- Glioma Diagnosis and Treatment
- Neurogenesis and neuroplasticity mechanisms
- Meningioma and schwannoma management
- Mesenchymal stem cell research
- Alzheimer's disease research and treatments
- Neuroinflammation and Neurodegeneration Mechanisms
- Cerebrospinal fluid and hydrocephalus
- Head and Neck Surgical Oncology
- Adrenal Hormones and Disorders
- Neurological Disease Mechanisms and Treatments
- Nerve injury and regeneration
- Pluripotent Stem Cells Research
- Extracellular vesicles in disease
- Neurological Disorders and Treatments
- Acute Ischemic Stroke Management
- Parkinson's Disease Mechanisms and Treatments
- Neuroendocrine Tumor Research Advances
- Biomedical Ethics and Regulation
- Cancer, Hypoxia, and Metabolism
- MicroRNA in disease regulation
- Nuclear Receptors and Signaling
- Immune cells in cancer
Chinese Academy of Medical Sciences & Peking Union Medical College
2016-2025
Peking Union Medical College Hospital
2016-2025
West China Hospital of Sichuan University
2024
Sichuan University
2024
Tongren Hospital
2021
Beijing Tongren Hospital
2021
Yangzhou University
2020
National Health and Family Planning Commission
2019
Creative Commons
2016
Dalian Medical University
2015
Alzheimer's disease (AD) is a leading cause of dementia worldwide, associated with cognitive deficits and brain glucose metabolic alteration. However, the associations changes dysfunction are less detailed. Here, we examined brains APP/presenilin 1 (PS1) transgenic (Tg) mice aged 2, 3.5, 5 8 months using 18F-labed fluorodeoxyglucose (18F-FDG) microPET to assess age- region-specific metabolism. FDG uptake was calculated as relative standardized value (SUVr). Morris water maze (MWM) used...
<b><i>Background:</i></b> There are no reliable predictive models for recurrence after transsphenoidal surgery (TSS) Cushing’s disease (CD). <b><i>Objectives:</i></b> This study aimed to develop machine learning (ML)-based CD initial TSS and evaluate their performance. <b><i>Method:</i></b> A total of 354 patients were included in this retrospective, supervised learning, data mining study. Predictive developed according...
Intracerebral hemorrhage (ICH) is a severe stroke subtype with limited therapeutic options.Programmed cell death (PCD) crucial for immunological balance, and includes necroptosis, pyroptosis, apoptosis, ferroptosis, necrosis.However, the distinctions between these programmed modalities after ICH remain to be further investigated.We used single-cell transcriptome (single-cell RNA sequencing) spatial (spatial techniques investigate PCD-related gene expression trends in rat brain following...
Our objective was to achieve the enhanced delivery of vascular endothelial growth factor (VEGF) ischemically disordered brain through transferrin-coupled liposomes (Tf-PLs) via intravenous administration, and observe effect Tf-VEGF-PLs on ischemic neuroprotection angiogenesis. Cerebral VEGF overexpression achieved with Tf-PLs by injection 48 hr after an acute stroke. β-Galactosidase expression monitored; saline injected as a control. The success postischemic gene transduction confirmed...
Transplantation of bone marrow-derived mesenchymal stem cells (BMSCs) is a potential therapy for cerebral ischemia. Although BMSCs-induced angiogenesis considered important neurological functional recovery, the neurorestorative mechanisms are not fully understood. We examined whether enhances tissue perfusion and creates suitable microenvironment within ischemic brain, which in turn accelerates endogenous neurogenesis leads to improved recovery. Adult female rats subjected 2 h middle artery...
Abstract Invasive pituitary adenomas (PAs) are often refractory to standard therapy and salvage treatment with temozolomide (TMZ). Hyperactivation of the phosphoinositide 3-kinase (PI3K)/AKT/mammalian target rapamycin (mTOR) pathway contributes chemotherapy resistance in many cancers. XL765, a novel dual-PI3K/mTOR inhibitor, has recently shown its efficacy as monotherapy combination conventional therapeutics The hyperactive PI3K/AKT/mTOR frequently occurs invasive PAs. In this study, we...
Alzheimer's disease (AD), the most frequent type of dementia, is featured by Aβ pathology, neural degeneration and cognitive decline. To date, there no cure for this disease. Neural stem cell (NSC) transplantation provides new promise treating AD. Many studies report that intra-hippocampal murine NSCs improved cognition in rodents with AD alleviating neurodegeneration via neuronal complement or replacement. However, few reports examined potential human NSC In study, we implanted...
Background: Prediction of the tumor consistency before surgery is vital importance to determine individualized therapeutic schemes for patients with acromegaly. The present study was performed noninvasively predict based on magnetic resonance imaging and radiomics analysis. Methods: In total, 158 acromegaly were randomized into primary cohort (n = 100) validation 58). classified as soft or firm according neurosurgeon's evaluation. critical features determined using elastic net feature...
The tumor immune microenvironment is associated with clinical outcomes and immunotherapy responsiveness.To investigate the intratumoral profile of pituitary adenomas (PAs) its relevance to explore a novel classification for predicting responsiveness.The transcriptomic data from 259 PAs 20 normal pituitaries were included analysis. ImmuCellAI algorithm was used estimate abundance 24 types tumor-infiltrating cells (TIICs) expression checkpoint molecules (ICMs).The distributions TIICs differed...
Studies on hyperprolactinemia and hypopituitarism in acromegaly are limited. We aimed to analyze the preoperative status, postoperative alterations, correlated factors of patients.This is a single-center cohort study with long-term follow-up. prospectively enrolled 529 patients. Hyperprolactinemia were evaluated by testing hypothalamus-pituitary-end organ (HPEO) axes hormones before after surgery.Hyperprolactinemia (39.1%) (34.8%) common acromegaly. The incidences axis-specific varied...
OBJECTIVE Treatment outcomes following initial transsphenoidal surgery (TSS) for acromegaly are erratic. Identifying outcome patterns can assist in informing patients about possible treatment and planning individualized adjuvant treatments advance. In this study, the authors aimed to investigate immediate long-term endocrine remission rates TSS acromegaly, identify clinical determinants of outcomes, explore during a follow-up pattern-specific patient features. METHODS This prospective,...
Attempts have been made to use cell transplantation and biomaterials promote proliferation, differentiation, migration, survival, as well angiogenesis, in the context of brain injury. However, whether bioactive materials can repair damage caused by ischemic stroke activating endogenous neurogenesis angiogenesis is still unknown. In this study, we applied chitosan gel loaded with basic fibroblast growth factor cavity 7 days after rats. The slowly released factor, which improved local...
Ischemic stroke is a significant global health crisis, frequently resulting in disability or death, with limited therapeutic interventions available. Although various intrinsic reparative processes are initiated within the ischemic brain, these mechanisms often insufficient to restore neuronal functionality. This has led intensive investigation into use of exogenous stem cells as potential option. comprehensive review outlines ontogeny and activation endogenous neural adult brain following...