A5074121633- Respiratory viral infections research
- Pleural and Pulmonary Diseases
- Prenatal Screening and Diagnostics
- Lung Cancer Diagnosis and Treatment
- Occupational and environmental lung diseases
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Parvovirus B19 Infection Studies
- Congenital Heart Disease Studies
- Aortic Disease and Treatment Approaches
- RNA modifications and cancer
- Viral gastroenteritis research and epidemiology
- Hemoglobinopathies and Related Disorders
- Fetal and Pediatric Neurological Disorders
- Cardiac Valve Diseases and Treatments
- Congenital Diaphragmatic Hernia Studies
- Pneumonia and Respiratory Infections
- Iron Metabolism and Disorders
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Genetic Syndromes and Imprinting
- Virus-based gene therapy research
- Gestational Diabetes Research and Management
- Pregnancy and preeclampsia studies
- Blood groups and transfusion
- Viral Infections and Immunology Research
- Genomic variations and chromosomal abnormalities
Capital Medical University
2015-2025
Chinese Academy of Medical Sciences & Peking Union Medical College
2020-2025
Beijing Children’s Hospital
2017-2025
First Affiliated Hospital of Henan University
2024
Beijing Chao-Yang Hospital
2010-2024
Beijing Obstetrics and Gynecology Hospital
2023-2024
Peking Union Medical College Hospital
2024
Shanghai University of Traditional Chinese Medicine
2024
Southern Marine Science and Engineering Guangdong Laboratory (Guangzhou)
2024
Jinan University
2024
<b><i>Background:</i></b> The differential diagnosis of pleural effusions can present a considerable challenge, and the etiology varies depending on population studied. <b><i>Objective:</i></b> This study aimed to assess efficacy safety medical thoracoscopy in patients with undiagnosed Chinese population. <b><i>Methods:</i></b> Between July 2005 June 2014, (MT) using semirigid instrument was performed 833 unknown our...
Diabetes is a global health crisis with rising incidence, mortality, and economic burden. Traditional markers like HbA1c are insufficient for capturing short-term glycemic fluctuations, leading to the need more precise metrics such as Glucose Variability (GV) Time in Range (TIR). Continuous Monitoring (CGM) AI integration offer real-time data analytics personalized treatment plans, enhancing control reducing complications. The combination of transcutaneous auricular vagus nerve stimulation...
Medical thoracoscopy has been shown to be an efficacious procedure in diagnosing unexplained exudative pleural effusions with excellent safety. This study aimed assess the diagnostic significance of management patients malignant effusion (MPE). Consecutive were retrospectively reviewed, and their demographic, radiographic, thoracoscopic histological data collected. Between July 2005 June 2014, 342 833 undergoing finally confirmed suffer from MPE. The top three frequent causes MPE metastatic...
Although some parameters of positron emission tomography with 18F-fluorodeoxyglucose (18F-FDG) and computed (PET-CT) are somehow helpful in differentiating malignant pleural effusion (MPE) from benign effusions, no individual parameter offers sufficient evidence for its implementation the clinical practice. The aim this study was to establish diagnostic accuracy a scoring system based on PET-CT (the score) diagnosing MPE.One prospective derivation cohort patients effusions (84 115 benign)...
Abstract Background Mycoplasma pneumoniae ( M. ) is an important pathogen of community-acquired pneumonia (CAP) in children. The coinfection rate (MPP) can reach 52% some areas, but the effects with different pathogens have not been clearly recognized. Methods cases MPP hospitalized Beijing Children’s Hospital from 1/1/2014 to 12/31/2016 were screened. patients coinfected Human adenovirus (HAdV) categorized into research group. Patients single infection control group, matching group by age...
To identify the variations in fusion (F) protein gene of RSV China, a molecular epidemiological study was conducted. A total 553 positive specimens were collected from 2338 pediatric patients hospitalized with community-acquired pneumonia during multi-center conducted 2014-2016. 252 samples (183 A, 69 B) selected for F sequencing, and analyzed together 142 sequences downloaded GenBank. The result showed that all Chinese B strains could be divided respectively into three branches. Compared...
Thoracoscopy is highly sensitive and accurate for detecting pleural effusions. However, most respiratory physicians are not familiar with the use of more common rigid thoracoscope or flexible bronchoscope, which difficult to manipulate within cavity. The semi-rigid combines best features instruments. Since practice this instrument limited in China, diagnostic utility thoracoscopy (namely medical thoracoscopy) under local anesthesia undiagnosed exudative effusions was evaluated.In 50 patients...
Inflammatory signaling networks between tumor cells and immune contribute to the development of malignant pleural effusion (MPE). B have been found in MPE; however, little is known about their roles there. In present study, by using mouse MPE models, we noted that although total were decreased as compared with corresponding blood spleen, percentage activated naïve expressing higher levels CD80, CD86, myosin heavy chain-II, CD44, CD69, programmed cell death-ligand 1 (PD-L1) molecules...
The aim of this retrospective study is to determine the monogenic syndromes in fetuses with isolated first-trimester increased nuchal translucency (NT) order provide more accurate parental counseling.Medical trio exome sequencing (ES) was performed on DNA extracted from chorionic villi 73 NT (≥3.5 mm) and normal chromosomal microarray analysis (CMA). This testing targets coding exons for 4200 clinically relevant disease-causing genes. interpretation variants according American College...
Qingfei Paidu decoction (QFPD) has been repeatedly recommended for the clinical treatment of novel coronavirus disease 2019 (COVID-19) in multiple provinces throughout China. A possible complication COVID-19 lung involvement is pulmonary fibrosis, which causes chronic breathing difficulties and affects patient's quality life. Therefore, there an important question regarding whether QFPD can alleviate process fibrosis its potential mechanisms. To explore this issue, study demonstrated...
β2-Microglobulin (β2M), the light chain of major histocompatibility complex class I (MHC I), has been identified as a proaging factor and is involved in pathogenesis neurodegenerative disorders by driving cognitive regenerative impairments. However, little attention focused on effect β2M development lung emphysema. Here, we found that concentrations plasma were significantly elevated patients with emphysema than those normal control subjects (1.89 ± 0.12 vs. 1.42 0.06 mg/l, P < 0.01)....
Respiratory syncytial virus (RSV) is the most common viral cause of pediatric bronchiolitis and pneumonia worldwide. Risk factors for high mortality prolonged morbidity after RSV infection include premature birth, bronchopulmonary dysplasia, congenital heart disease, Down syndrome. However, some previously healthy, full-term children who are infected with also require hospitalization even experience severe sequelae or death. In this report, we present case an RSV-associated death a child was...
In adults, the emerging human adenovirus (HAdV) type 55 (HAdV-55) has been reported to cause more severe cases of induced acute lower respiratory tract infections (ALRTIs) compared other HAdV serotypes (HAdV-3, HAdV-7, HAdV-14). However, there is a dearth comparative studies in children that address differences clinical epidemiological features between HAdV-55 and can also induce infection (such as HAdV-7).We conducted retrospective review pediatric patients hospitalized at Beijing...
Abstract Background Selective intrauterine fetal growth restriction (sIUGR) in monochorionic diamniotic twins, especially types 2&3 with abnormal umbilical artery Doppler, results increased risk of fetal/perinatal mortality and postnatal disability. We investigate whether the hair metabolome profiles neonates were associated pathophysiological differences across different clinical forms sIUGR twins. Methods Hair samples collected at delivery from 10 pairs type 1 8 11 twins without sIUGR....
Abstract Aims This study aimed to evaluate the association between gestational diabetes mellitus (GDM) and circulating folate metabolites, folic acid (FA) intake, methylenetetrahydrofolate reductase ( MTHFR ) methionine synthase MTRR genotype. Materials Methods A prospective pregnancy cohort was conducted in Beijing, China, from 2022 2023. Circulating including red blood cell (RBC) 5‐methyltetrahydrofolate (5‐MTHF), 5, 10‐methylene‐tetrahydrofolate (5,10‐CH2‐THF), 5‐ formyltetrahydrofolate...
Background: No data on the incidence of pleural effusion (PE) in Chinese patients with pulmonary embolism are available to date. The aim current study was investigate frequency PE a population embolism. Methods: This retrospective observational single-center study. All computed tomography angiography (CTPA) performed over 6-year period adult clinically suspected were analyzed. Results: From January 2008 until December 2013, identified 423 3141 (13.5%) who underwent CTPA. (19.9%)...
In the present study, 50 nasopharyngeal swabs from children with community‐acquired pneumonia (CAP) but negative for 18 common respiratory viruses, as measured by Luminex xTAG Respiratory Viral Panel Assay, were subjected to multiplex metagenomic analyses using a next‐generation sequencing platform. Taxonomic analysis showed that all sequence reads could be assigned specific species. An average of 95.13% Bacteria kingdom, whereas, only 0.72% potentially virus derived. This snapshot tract...
Abstract The role of IL‐10 in malignant pleural effusion (MPE) remains unknown. By using murine MPE models, we observed that an increase was a significant predictor increased risk death. We noted T H 1‐ and 17‐cell content higher –/– mice than WT mice, deficiency promoted differentiation into 1 but not 17 cells. A fraction cells the expressed CXCR3 compared with mice. also demonstrated Lewis lung cancer colon adenocarcinoma secreted large amounts CXCL10, ligand CXCR3, which induced migration...