A5103282377- Plant Molecular Biology Research
- Gestational Diabetes Research and Management
- Plant Reproductive Biology
- Pregnancy and preeclampsia studies
- Tryptophan and brain disorders
- Plant nutrient uptake and metabolism
- Diabetes and associated disorders
- Thyroid Disorders and Treatments
- Birth, Development, and Health
- Extracellular vesicles in disease
- Immune Cell Function and Interaction
- Light effects on plants
- Clostridium difficile and Clostridium perfringens research
- Gut microbiota and health
- Neuroinflammation and Neurodegeneration Mechanisms
- Photosynthetic Processes and Mechanisms
- Genetics and Neurodevelopmental Disorders
- Medical Research and Treatments
- Genetic Associations and Epidemiology
- Immunodeficiency and Autoimmune Disorders
- Plant Physiology and Cultivation Studies
- Polysaccharides and Plant Cell Walls
- Growth Hormone and Insulin-like Growth Factors
- Quinazolinone synthesis and applications
- Hippo pathway signaling and YAP/TAZ
Beijing Obstetrics and Gynecology Hospital
2022-2024
Capital Medical University
2022-2024
Hebei Normal University
2022-2024
Xian Yang Central Hospital
2024
Kunming Medical University
2021-2023
First Affiliated Hospital of Kunming Medical University
2021-2023
Zhejiang A & F University
2023
Nanjing Agricultural University
2023
Hengshui University
2023
Sun Yat-sen University
2022
Abstract Hepatocellular carcinoma (HCC), a common liver malignancy worldwide, has high morbidity and mortality. β-Thujaplicin, tropolone derivative, been used in some health-care products clinical adjuvant drugs, but its use for HCC is unknown. In this study, we found that β-Thujaplicin inhibits the growth of cells, not normal with nanomolar potency. Mechanistically, could induce autophagy, as judged by western blot, confocal microscopy, transmission electron microscopy. Further using...
Congenital hypothyroidism (CH), the most common neonatal metabolic disorder, is characterized by impaired neurodevelopment. Although several candidate genes have been associated with CH, comprehensive screening of causative has limited.One hundred ten patients primary CH were recruited in this study. All exons and exon-intron boundaries 21 for analyzed next-generation sequencing. And inheritance pattern was study family pedigrees.Our results showed that 57 (51.82%) carried biallelic...
Metformin exhibits therapeutic potential in behavioural deficits induced by methamphetamine (METH) rats. Emerging studies suggest gut microbiota may impact psychiatric symptoms, but there is no direct evidence supporting metformin's participation the pathophysiology of withdrawal symptoms via modulation microbiota.In order to define functional impacts and metformin during METH withdrawal, we utilized a combination fecal transplantation (FMT), high-throughput sequencing, untargeted...
Lateral roots (LRs) are an important part of plant root systems. In dicots, for example, after plants adapted from aquatic to terrestrial environments, filamentous pseudorhizae evolved allow nutrient absorption. A typical system comprises a primary root, LRs, hairs, and cap. Classical exhibit geotropism (the tendency grow downward into the ground) can synthesize hormones other essential substances. Root vascular bundles complex spatial structures enable absorb water nutrients meet their...
Abstract In cell–cell communication, noncell-autonomous transcription factors play vital roles in controlling plant stem cell fate. We previously reported that AUXIN RESPONSE FACTOR3 (ARF3), a member of the ARF family with critical floral meristem maintenance and determinacy, has distinct accumulation pattern differs from expression domain its encoding gene shoot apical (SAM). However, biological meaning this difference is obscure. Here, we demonstrate ARF3 Arabidopsis (Arabidopsis thaliana)...
Despite decades of research in the field substance withdrawal, molecular biomarkers and related mechanistic study have generally been lacking. In addition to known neurotransmitters, circulating miRNAs are found small vesicles as exosomes within blood that diagnostic potential contribute psychiatric disorders. The aim this work was characterize changes neurotransmitter exosomal miRNA profiles during heroin methamphetamine withdrawal using a cross-sectional design, determine their...
After germination in the dark, plants produce a shoot apical hook and closed cotyledons to protect quiescent meristem (SAM), which is critical for seedling survival during skotomorphogenesis. The factors that coordinate these processes, particularly SAM repression, remain enigmatic. Plant cuticles, multilayered structures of lipid components on outermost surface aerial epidermis all land plants, provide protection against desiccation external environmental stresses. Whether how cuticles...
species have great potential in fighting chronic and hidden hunger. In this study, five
Abstract Aims To identify the gestational weight gain (GWG) patterns in women with diabetes mellitus (GDM) and evaluate their association offspring status from birth to 40 months. Materials methods This study included 2,723 GDM-mother–child pairs Beijing Birth Cohort Study. The between GWG trajectories identified by latent class model outcomes months were evaluated, after adjustment for maternal age, parity, pre-pregnancy body mass index, height, blood glucose levels. Results Three rate...
Abstract Aims This study aimed to evaluate the association between gestational diabetes mellitus (GDM) and circulating folate metabolites, folic acid (FA) intake, methylenetetrahydrofolate reductase ( MTHFR ) methionine synthase MTRR genotype. Materials Methods A prospective pregnancy cohort was conducted in Beijing, China, from 2022 2023. Circulating including red blood cell (RBC) 5‐methyltetrahydrofolate (5‐MTHF), 5, 10‐methylene‐tetrahydrofolate (5,10‐CH2‐THF), 5‐ formyltetrahydrofolate...
Time to flower, a process either referring juvenile–adult phase change or vegetative–reproductive transition, is strictly controlled by an intricate regulatory network involving at least both FT/TFL1 and the micro RNA (miR)156-regulated SPL family members. Despite substantial progresses recently achieved in Arabidopsis other plant species, information regarding involvement of these genes during orchid development flowering competence still limited. Dendrobium catenatum, popular exhibits...
Abstract Context Hashimoto’s thyroiditis (HT) and Graves’ disease (GD) are the 2 main autoimmune thyroid diseases that have both similarities differences. Determining genetic basis distinguishes HT from GD is key for a better understanding of differences between these closely related diseases. Objects To identify susceptibility genes in Chinese cohort compare HT. Design In current study, 18 SNPs established risk loci were selected then genotyped 2682 patients with HT, 4980 GD, 3892 controls....
Heroin addiction and withdrawal influence multiple physiological functions, including immune responses, but the mechanism remains largely elusive. The objective of this study was to investigate molecular inflammatory interactome, particularly cytokines transcriptome regulatory network in heroin addicts undergoing withdrawal, compared healthy controls (HCs). Twenty-seven were simultaneously assessed 41 addicts, 20 at acute (AW) stage 21 protracted (PW) stage, 38 age- gender-matched HCs....
Aims The global COVID-19 pandemic has required a drastic transformation of prenatal care services. Whether the reformulation antenatal systems affects maternal and infant outcomes remains unknown. Particularly, women with gestational diabetes mellitus (GDM) are among those who bear greatest brunt. Thus, this study aimed to evaluate impact lockdown during late pregnancy on in stratified by GDM status China. Study design participants were experienced (3185 2020 cohort) or not (2540 2019 that...
<h3>Importance</h3> Thyrotoxic periodic paralysis (TPP) is a potentially lethal complication of hyperthyroidism. However, only 1 specific susceptibility locus for TPP has been identified. Additional genetic determinants should be detected so that prediction model can constructed. <h3>Objective</h3> To investigate the architecture and distinguish from Graves disease cohorts. <h3>Design, Setting, Participants</h3> This population-based case-control study used 2-stage genome-wide association to...
Abstract Background Maternal overweight/obesity and excessive gestational weight gain (GWG) are frequently reported to be risk factors for obesity other metabolic disorders in offspring. Cord blood metabolites provide information on fetal nutritional health could an early window of detection potential issues among newborns. The aim the study was explore impact maternal prepregnancy GWG cord profiles. Methods A case control including 33 pairs mothers with their neonates, 30 32 mother-neonate...
Abstract Context: Graves disease (GD) is a common autoimmune triggered by genetic predisposition and environmental factors. However, the mechanisms of interaction between factors contributing to development GD remain unknown. Objective: We aimed identify susceptibility variants genes on Xq21.1 locus interpret contribution GD. Design: performed refining study in 2-stage carried out expression quantitative trait analysis best association signal with Setting Participants: A total 4316 patients...