A5101654360- Aquaculture disease management and microbiota
- interferon and immune responses
- RNA modifications and cancer
- Mechanical Circulatory Support Devices
- RNA and protein synthesis mechanisms
- Traditional Chinese Medicine Analysis
- Ultrasound and Hyperthermia Applications
- Thermoelastic and Magnetoelastic Phenomena
- Complement system in diseases
- Cell death mechanisms and regulation
- Natural product bioactivities and synthesis
- Invertebrate Immune Response Mechanisms
- Epigenetics and DNA Methylation
- Cardiac Arrest and Resuscitation
- RNA Research and Splicing
- Calpain Protease Function and Regulation
- Dermatologic Treatments and Research
- Ubiquitin and proteasome pathways
- Burn Injury Management and Outcomes
- Cancer, Hypoxia, and Metabolism
- Laser Applications in Dentistry and Medicine
- Advanced Power Generation Technologies
- Advanced Drug Delivery Systems
- High Entropy Alloys Studies
- Titanium Alloys Microstructure and Properties
Liaoning Normal University
2019-2025
Dalian Polytechnic University
2020-2025
Shanghai Jiao Tong University
2018-2025
Shanghai Institute of Materia Medica
2019-2023
Chinese Academy of Sciences
2014-2023
Jiangsu Province Hospital
2021-2022
Nanjing Medical University
2021-2022
Tianjin Medical University General Hospital
2021
Shanghai Ninth People's Hospital
2017-2018
China National Building Materials Group (China)
2016
Congenital hypothyroidism (CH), the most common neonatal metabolic disorder, is characterized by impaired neurodevelopment. Although several candidate genes have been associated with CH, comprehensive screening of causative has limited.One hundred ten patients primary CH were recruited in this study. All exons and exon-intron boundaries 21 for analyzed next-generation sequencing. And inheritance pattern was study family pedigrees.Our results showed that 57 (51.82%) carried biallelic...
Seawater electrolysis has emerged as a promising approach for the generation of hydrogen energy, but production deleterious chlorine derivatives (e.g., chloride and hypochlorite) presents significant challenge due to severe corrosion at anode. Transition metal-coordinated polymers have garnered attention electrocatalysts alkaline seawater oxidation (ASO), attributed their remarkable resistance, high conductivity, facile synthesis. In this study, we employ an anodic...
Abstract The Rels, a class of nuclear factor κB (NF-κB) complexes, regulate diverse physiological processes by modulating the transcription effector genes. IκBs are critical proteins that inhibit NF-κB translocation, thereby disrupting NF-κB-mediated signaling pathways. Despite this, precise role and underlying molecular mechanisms Rel IκB transcriptional regulation mediated in lamprey, member oldest surviving vertebrates, remain incompletely understood. In this study, we cloned identified 4...
The present study was carried out to investigate the potential of cationic functionalization on imatinib nanocrystals improve mucoadhesiveness and, thus, delivery lesion cervicovaginal tumors. Amino-group-functionalized (NC@PDA-NH₂) were prepared with near-spheroid shape, nanoscale size distribution, positive zeta potential, and relatively high drug content aid polydopamine-coating technique. Efficient interaction between NC@PDA-NH₂ mucin proven by adsorption which related zeta-potential...
The programmed cell death (PDCD) family plays a significant role in the regulation of survival and apoptotic death. However, evolution, distribution PDCD lampreys have not been revealed. Thus, we identified gene lamprey genome classified genes into five subfamilies based on orthologs genes, conserved synteny, functional domains, phylogenetic tree motifs. immune response stimulated by different pathogens were also demonstrated. In addition, investigated molecular function PDCD2, PDCD5 PDCD10....
The human genome encodes two melatonin receptors (MT1 and MT2) that relay signals to cellular interior. Accumulating evidence has linked multiple health benefits, among which its anticancer effects have become well-established. However, the implications of in lung adenocarcinoma so far remained incompletely understood.This study aims investigate response MT1 receptor treatment dynamic regulation by ubiquitin-specific protease 8 (USP8) adenocarcinoma.The mRNA levels MT2 were analyzed with...
Abstract Introduction Olfactory dysfunction is a common and early sign of many neurodegenerative disorders, but little known about olfactory in Wilson’s disease (WD). We aimed to evaluate function patients with WD identify selective screening odors. Methods measured identification ability 25 healthy controls using the University Pennsylvania Smell Identification Test (UPSIT). Patients were evaluated Global Assessment Scale for (GAS). Cognitive was Mini–Mental State Examination. Results worse...
Alternative splicing of pre-mRNAs greatly contributes to diversity in products generated from a single gene. However, the underlying regulatory mechanisms are poorly understood. In present study, we describe evolutionarily conserved intra-intronic and inter-intronic RNA secondary structures. Mutation experiments revealed that structure causes steric hindrance enforce mutual exclusivity, while pairing largely functions through looped-out mechanism. Moreover, mutually exclusive may be...
Studies have shown an association of the UNC5D gene with kidney and bladder cancer neuroblastoma. We investigated whether acts as a tumor suppressor in papillary thyroid carcinoma (PTC).Primary PTC tumors matched normal tissues were obtained from 112 patients to detect mRNA by real-time PCR. Genomic DNA sequencing was performed BRAF mutation tumors. The between expression clinicopathological data reviewed retrospectively. PTC-derived cell lines TPC-1 K1 stable transfection used investigate...
Cryosurgery is a surgical technique that employs freezing to destroy target tumor tissue. While the main objective during cryosurgical procedure ensure tissue destruction within cryolesion, greatest challenge how spare surrounding healthy tissues from cryoablation. In this work, historical review of field cryosurgery presented followed by theoretical study where mathematical model developed for on basal cell carcinoma (BCC) using liquid nitrogen ( LN 2 ) spray. The takes into consideration...
It is common in some cryosurgical procedures to rely on freeze-thaw cycle(s) destroy undesirable tissues. Most research cryosurgery focuses the freezing process and much less attention has been paid thawing or re-warming. However, as ice melts during thawing, extracellular solution can become locally hypotonic, driving water into cells, resulting cell expansion ultimately, membrane rupture. Therefore, thermal history of target tissue both processes critical for viability. To better...
To study the correlation between mean arterial pressure (MAP) level in first 6 hours of extracorporeal cardiopulmonary resuscitation (ECPR) and patients' neurological outcomes.Sex, age, basic comorbidities, time from cardiac arrest to start CPR, membrane oxygenation (ECMO), standardized ECMO flow, pH value at beginning after were recorded. MAP was recorded every 2 during hours, average calculated. The lactic acid clearance rate Evaluated prognosis patients discharge. Then divided into groups...
Basel cell carcinoma (BCC) is the most common human skin malignancy. Its incidence has increased significantly in Australia, Europe and North America over past decade. A number of modalities are currently used for treatment BCC, including cryosurgery which offers a potential high cure rate, low cost, minimal bleeding good cosmetic effect. However, not frequently BCC because no current method exists to design adequate parameters. We present numerical analysis on thermal history target tissue...
The eradication of <i>Trichophyton rubrum</i> has been attempted via laser irradiation because it could result advantageous relative to current clinical therapies. Anticipating that the necessary thermal effects unintentionally damage underlying toe dermal layer, we have explored two auxiliary approaches: (a) under vacuum pressure, with and without water dousing and, (b) cooling followed by heating (thermal shock). rationale is at low pressures, temperature achieve evaporation/boiling...