A5045589827- Dermatologic Treatments and Research
- Optical Coherence Tomography Applications
- Laser Applications in Dentistry and Medicine
- Skin Protection and Aging
- Vascular Malformations and Hemangiomas
- Cutaneous Melanoma Detection and Management
- Advanced Fluorescence Microscopy Techniques
- Photoacoustic and Ultrasonic Imaging
- Photodynamic Therapy Research Studies
- Optical Imaging and Spectroscopy Techniques
- Thermoregulation and physiological responses
- Cell Image Analysis Techniques
- Advanced Biosensing Techniques and Applications
- Facial Rejuvenation and Surgery Techniques
- Nail Diseases and Treatments
- Genetic and rare skin diseases.
- Nonmelanoma Skin Cancer Studies
- melanin and skin pigmentation
- Vascular Tumors and Angiosarcomas
- Ocular and Laser Science Research
- Cutaneous lymphoproliferative disorders research
- Diagnosis and Treatment of Venous Diseases
- Acne and Rosacea Treatments and Effects
- Tumors and Oncological Cases
- Body Contouring and Surgery
University of California, Irvine
2015-2024
Beckman Laser Institute and Medical Clinic
2015-2024
Johns Hopkins University
2024
University of Kansas Medical Center
2024
John Wiley & Sons (United States)
2023
Liechtenstein Institute
2023
Massachusetts General Hospital
2023
University of Hong Kong
2023
University of Nevada, Las Vegas
2023
Ghent University
2022
Background: Cryogen spray cooling can be used to provide epidermal protection while still achieving spatially selective photocoagulation in the upper dermis.The objective of this study is determine efficacy and safety cryogen combination with a nonablative Nd:YAG ( = 1320 nm) laser treatment facial rhytides human volunteers.Observations: Thirty-five adults bilateral periorbital were treated 3 treatments performed sequentially at intervals 2 weeks.Small but statistically significant...
Basal cell carcinomas (BCCs) are diagnosed by clinical evaluation, which can include dermoscopic biopsy, and histopathologic examination. Recent translation of multiphoton microscopy (MPM) to practice raises the possibility noninvasive, label-free in vivo imaging BCCs that could reduce time from consultation treatment.To demonstrate capability MPM image BCC lesions human skin, evaluate if criteria be identified images.Imaging patients with was performed at University California-Irvine Health...
Abstract Monitoring of atypical nevi is an important step in early detection melanoma, a clinical imperative preventing the disease progression. Current standard diagnosis based on biopsy and histopathologic examination, method that invasive highly dependent upon physician experience. In this work, we used multiphoton microscope to image vivo noninvasively melanocytic at three different stages: common without dysplastic changes, with structural architectural atypia, melanoma. We analyzed...
In vivo, label-free evaluation of mitochondrial function in human skin epithelia noninvasively differentiates healthy from cancerous tissues.
Due to the significant risk profile associated with traditional ablative resurfacing, a safer and less invasive treatment approach known as fractional deep dermal ablation (FDDA) was recently developed. We report results of first clinical investigation this modality for photodamaged skin.Twenty-four subjects received treatments on inner forearm prototype CO(2) laser device (Reliant Technologies Inc., Mountain View, CA) at settings 5-40 mJ/MTZ 400 MTZ/cm(2). Clinical histological effects were...
The ability to quantitatively determine tissue fluorescence is of interest for the purpose better understanding details photodynamic therapy skin cancer. In particular, we are interested in quantifying protoporphyrin IX (PpIX) vivo. We present a method correcting effects native absorption and scattering properties spatially resolved manner that preserves resolution imaging system, based off homogeneous representation tissue. Validation was performed using series liquid turbid phantoms having...
The combined use of nonlinear optical microscopy and broadband reflectance techniques to assess melanin concentration distribution thickness in vivo over the full range Fitzpatrick skin types is presented. Twelve patients were measured using multiphoton (MPM) spatial frequency domain spectroscopy (SFDS) on both dorsal forearm volar arm, which are generally sun-exposed non-sun-exposed areas, respectively. Both MPM SFDS volume fractions between (skin type I non-sun-exposed) 20% VI sun...
Importance Improvements in skin appearance resulting from treatment with fractionated picosecond‐lasers have been noted, but optimizing the efficacy depends on a thorough understanding of specific response. The development non‐invasive laser imaging techniques conjunction therapy can potentially provide feedback for guidance and clinical outcome. Objective purpose this study was to demonstrate capability multiphoton microscopy (MPM), high‐resolution, label‐free technique, characterize vivo...
The β-blocker carvedilol has been shown to prevent skin carcinogenesis in vitro and vivo. Since systemic absorption of the may cause cardiovascular disturbance, we developed a loaded transfersome for skin-targeted delivery. Transfersomes were prepared using phospholipids surfactants at various ratios characterized. One formulation (F18) selected further analysis was composed carvedilol, soy phosphatidylcholine, Tween-80 ratio 1:3:0.5, which had particle size 115.6 ± 8.7 nm, zeta potential...
Over the past few years, high-resolution optical imaging technologies such as coherence tomography (OCT), reflectance confocal microscopy (RCM), and multiphoton (MPM) have advanced significantly new methodologies for clinical research real-time detection, diagnosis, therapy monitoring of skin diseases. Implementation these into practice requires clinicians to an understanding their capabilities, benefits, limitations. This concise review provides insights on application OCT, RCM, MPM through...
Objective of the study is to assess effects wound healing with a commercially available light emitting diode (LED) photo biomodulation (PBM) device that emits three wavelengths (465, 640 and 880nm) after ablative fractional laser (AFL) treatment healthy skin on bilateral inner biceps. We conducted prospective intraindividual randomized controlled 25 volunteers. AFL was performed Subjects applied LED for 30 min assigned bicep 3 times week over 4 weeks, beginning day 0. were followed up days...
Breast cancer survivors (BCSs) have many lifelong symptoms of anxiety, depression, lymphedema, and fatigue that can be exacerbated by sleep disturbance. However, little is known about unique factors contributing to disturbance among BCSs with lymphedema; this requires further investigation offer appropriate support treatment these individuals. Therefore, the objective study was capture perceptions experiences lymphedema lymphedema.