Abstract Background and purpose Targeted therapy immunotherapy have led to dramatic change in the treatment of lung cancer, however, overall 5-year survival rate cancer patients is still suboptimal. It important exploit new potential molecularly targeted therapies. High-frequency somatic mutations KEAP1/NRF2 (27.9%) been identified squamous cell carcinoma. In this research, we explored role KEAP1 development LSCC whether a nuclear factor erythroid 2-related 2(NRF2) inhibitor be target...

Abstract JMJD3, a stress-inducible H3K27 demethylase, plays critical regulatory role in the initiation and progression of malignant hematopoiesis. However, how this histone modifier affects cell type-dependent manner remains unclear. Here, we show that contrast to its oncogenic effect preleukemia state lymphoid malignancies, JMJD3 relieves differentiation-arrest certain subtypes (such as M2 M3) acute myeloid leukemia (AML) cells. RNA sequencing ChIP−PCR analyses revealed exerts anti-AML by...

Chronic obstructive pulmonary disease (COPD) is a major public health problem and cause of mortality worldwide. However, COPD in the early stage usually not recognized diagnosed. It necessary to establish risk model predict development.A total 441 patients 192 control subjects were recruited, 101 single-nucleotide polymorphisms (SNPs) determined using MassArray assay. With 5 clinical features as well SNPs, 6 predictive models established evaluated training set test by confusion matrix...

Neutrophil infiltration is frequently observed in lung cancer tissues. Extracellular RNAs (exRNAs) may facilitate tumor progression. The present study investigated the cross‑talk of exRNAs and neutrophil extracellular traps (NETs) cancer. Lewis carcinoma (LLC) cells were cultured with deprived sera. And cell culture supernatants (CCS) analyzed vitro vivo. results revealed that from CCS promoted inflammatory cytokine interleukin‑1β reduced vascular adhesion molecule‑1 expression epithelial...

Abstract Background Ovarian cancer poses a serious threat to women's health. Due the difficulty of early detection, most patients are diagnosed with advanced-stage disease or peritoneal metastasis. We found that LncRNA MEG3 is novel tumor suppressor, but its role in occurrence and development still unclear. Methods investigated expression level pan-cancer through bioinformatics analysis, especially gynecological tumors. Function assays were used detect effect on malignant phenotype ovarian...

Develop a predicting model that can help stratify patients with epithelial ovarian cancer (EOC) before platinum-based chemotherapy. 148 pathologically confirmed EOC and minimum 5-year follow-up were retrospectively enrolled. Patients classified into platinum-sensitive platinum-resistant groups according to treatment responses. The correlation between clinical factors drug sensitivity was evaluated using statistical tests. Approximately 700,000 single-nucleotide polymorphism (SNP) sites...

Intravascular large B‑cell lymphoma (IVLBCL) is a rare subtype of lymphoma. The concurrence IVLBCL and papillary thyroid carcinoma (PTC) extremely rare. A 63‑year‑old woman was diagnosed with double‑expression that presented as hemophagocytic syndrome, complicated by PTC. positron emission tomography/computed tomography (PET/CT) before bone marrow biopsy. Immunofixation electrophoresis displayed M proteins positive IgG kappa light chains the differential diagnosis should have included both...

Cancer of unknown primary (CUP) is a malignancy characterized by metastatic disease at diagnosis with an unidentified site, accounting for 3–5% all cancers. Despite significant advancements in cancer and treatment recent years, CUP management has been challenging due to its complexity heterogeneity; therefore, prognosis remains poor. This report presents three cases CUP. The first case involved 59-year-old female whose abdominal was identified be originating from cervical using 90-gene...

Abstract Histone lysine demethylase 6a (Kdm6a) mediates the removal of repressive trimethylation from histone H3 27 (H3K27me3) to activate target gene expression. Obesity is associated with metabolic inflammation, and adipose tissue macrophages (ATMs) are key players orchestrating inflammation. However, it still unclear whether Kdm6a pathway in ATMs regulates energy homeostasis. Here, we identified as a critical epigenetic switch that modulates macrophage polarisation further disrupts...

Stroke is followed by an intricate immune interaction involving the engagement of multiple cells, including neutrophils. As one first responders recruited to brain, crucial roles neutrophils in ischemic brain damage are receiving increasing attention recent years. Notably, not homogenous, and yet there still a lack full knowledge about extent impact neutrophil heterogeneity. The biological understanding response both innate pathological conditions rapidly evolving as single-cell-RNA...

Insulin like growth factor 2 mRNA binding protein 3 (IGF2BP3) is a critical m6A reader.It encodes proteins that contain several KH domains, which are important in RNA binding, synthesis and metabolism.Lots of researches have studied the malignant potential readers tumors.However, biological functional analysis IGF2BP3 hepatocellular carcinoma (HCC) pan-cancer not comprehensive.In this study, we used bioinformatics approach to comprehensively analyze significance HCC through analyzing its...

Summary Objective Evidence from animal models and human studies suggests that CYP2J2 plays a mechanistic role in the development of hypertension. The present study aims to investigate potential genetic contribution gene etiology essential hypertension (EH) individual blood pressure. Methods We selected eight polymorphisms in/or around performed case‐control association involving 841 Han Chinese subjects, including 415 unrelated hypertensives 426 age‐, gender‐ area‐matched normotensives....

Investigated the association of DNA repair gene xeroderma pigmentosum group A(XPA) and C(XPC) polymorphisms with risk gastric cardiac adenocarcinoma (GCA) in a high incidence region north China.Polymorphisms number genes may contribute to variations capacity genetic susceptibility different cancers.Two single nucleotide XPA 3 XPC were genotyped 253 GCA patients 612 healthy controls.Family history upper gastrointestinal cancer increase developing GCA. Compared A/A genotype, A/G+G/G genotype...

Crizotinib is an orally administered drug for the treatment of patients with anaplastic lymphoma kinase (ALK)-positive locally advanced or metastatic non‑small cell lung cancer (NSCLC). Despite impressive efficacy crizotinib in ALK‑positive cancer, acquired resistance eventually develops majority patients. The microRNA (miR)‑200c reverses cells to various chemotherapeutic drugs and molecular targeted drugs, however, whether it can reverse remains unknown. present study established a...

Mounting epidemiology studies have reported the potential associations between ambient air pollution exposure and colorectal cancer (CRC). However, genetic association CRC remains unclear. Using Genome-wide study (GWAS) data from UK biobank, we explored of (5,657 cases 372,016 controls) with four pollutants (PM2.5, PM10, NO2, NOx; n = 423,796 to 456,380) under framework Mendelian randomization (MR). Our results revealed a significant long-term NO2 (per 10 µg/m3) increased risk, an odds ratio...

Piericidin A1, a member of ɑ-pyridone antibiotic, exhibits various biological activities such as antimicrobial, antifungal, and antitumor properties possesses potent respiration-inhibitory activity against insects due to its competitive binding capacity mitochondrial complex I. The biosynthetic pathway piericidin A1 has been reported in Streptomyces piomogeues var. Hangzhouwanensis, while the regulatory mechanism remains poorly understood. In this study, antibiotic protein (SARP) family...

Background: Vascular endothelial growth factor (VEGF) is a major angiogenic involved in number of pathological processes, including neovascularization, crucial step the development solid malignancies. The aim this study was to investigate association polymorphisms VEGF gene with susceptibility epithelial ovarian cancer (EOC). Methods: This case-control included 303 EOC patients and healthy controls. Genotyping at −460 C/T , −1154 G/A −2578 C/A +936 were performed by polymerase chain reaction...

Real-time dynamic imaging of immunoactivation-related cytokines is crucial for evaluating the efficacy immune checkpoint blockade therapy and optimizing treatment regimen. We introduce herein a spatiotemporally controlled nanodevice that allows in situ photoactivated interferon-gamma (IFN-γ) secretion from T cells vitro vivo. The constructed by rational engineering an aptamer-embedded, UV-cleavable PC-DNA probe further integration with upconversion nanoparticles- CRISPR-Cas12a-enhanced...

Lung cancer is the leading cause of death worldwide and accounts for more than one-third all newly diagnosed cases in China. Therefore, it great clinical significance to explore new driver gene mutations non-small-cell lung (NSCLC). Using an initial bioinformatic analysis, we identified somatic 13 patients with NSCLC confirmed these by targeted sequencing extended validation group 88 patients. Recurrent were detected UNC5D (7.9%), PREX1 (5.0%), HECW1 (4.0%), DACH1 (2.0%), GPC5 (2.0%). A...

Ozone (O3) is an important urban air pollutant having strong correlations with respiratory diseases. Several lines of evidence suggest that O3 exposure causes airway hyperresponsiveness (AHR) and pulmonary inflammation. Inhibitory innate immune receptors, such as NLRP12, have been demonstrated to alleviate inflammation, but the functional role for NLRP12 in O3-induced lung inflammatory inflammation remains be reported. Here, we determined whether took a protective AHR via suppression...