A5073803027- Viral Infections and Immunology Research
- COVID-19 Clinical Research Studies
- Air Quality and Health Impacts
- SARS-CoV-2 and COVID-19 Research
- CRISPR and Genetic Engineering
- RNA regulation and disease
- Viral gastroenteritis research and epidemiology
- Animal Disease Management and Epidemiology
- interferon and immune responses
- Cytomegalovirus and herpesvirus research
- Climate Change and Health Impacts
- COVID-19 epidemiological studies
- Bacteriophages and microbial interactions
- Antimicrobial Resistance in Staphylococcus
- Antibiotic Resistance in Bacteria
- Heme Oxygenase-1 and Carbon Monoxide
- COVID-19 and healthcare impacts
- Long-Term Effects of COVID-19
- COVID-19 and Mental Health
- Bacterial biofilms and quorum sensing
- Herpesvirus Infections and Treatments
- Mosquito-borne diseases and control
- Cancer-related molecular mechanisms research
- Inflammasome and immune disorders
- RNA Research and Splicing
Zhengzhou University
2016-2025
Zhengzhou Children's Hospital
2024
Xinxiang University
2024
Duke Medical Center
2018-2019
Duke University Hospital
2018-2019
Hepatitis B remains a major global public health challenge, with particularly high prevalence in medically disadvantaged western Pacific and African regions. Although clinically available technologies for the qPCR detection of HBV are well established, research on point-of-care testing has not progressed substantially. The development rapid, accurate test is essential prevention control hepatitis rural areas. CRISPR/Cas system nucleic acid allowed pathogen detection. Here, we developed rapid...
Epidemiological studies have shown that exposure to ambient fine particulate matter (PM2.5 ) is associated with respiratory diseases. Lung inflammation a central feature of many pulmonary diseases, which can be induced by PM2.5 exposure. However, the mechanisms underlying -induced lung remain unclear. To characterize role epidermal growth factor receptor (EGFR) and inflammasome in mice, 30 BALB/c mice were intrabroncheally instilled saline suspension (4.0 mg/kg b.w.) for 5 consecutive days,...
Growing evidences indicate that inflammation induced by PM2.5 exposure has been considered as a major driving force for the development of cardiovascular diseases. However, mechanisms underlying -induced cardiac injury remain unclear. This study aims to investigate role NLRP3 inflammasome in functional and pathological mice. In this study, BALB/c mice were intratracheally instilled with suspension (4.0 mg/kg BW) 5 days set up model, which was evaluated electrocardiogram monitoring, HE Masson...
Severe acute respiratory syndrome coronavirus (SARS-CoV) was discovered as a novel pathogen in the 2002-2003 SARS epidemic. The emergence and disappearance of this have brought questions regarding its source evolution. Within genome sequences 281 SARS-CoVs, severe 2 (SARS-CoV-2), SARS-related CoVs (SARSr-CoVs), ~430 bp genomic region (from 27 701 to 28 131 AY390556.1) with regular variations investigated. This overlaps ORF8 gene is prone deletions nucleotide substitutions. Its complexity...
Abstract Background In the aftermath of COVID-19 pandemic, there has been a surge in human metapneumovirus (HMPV) transmission, surpassing pre-epidemic levels. We aim to elucidate clinical and epidemiological characteristics HMPV infections post-COVID-19 pandemic era. Methods this retrospective single-center study, participants diagnosed with laboratory confirmed infection through Targeted Next Generation Sequencing were included. The study encompassed individuals admitted Henan Children's...
Purpose The childhood hand, foot and mouth disease (HFMD) sequelae cohort study (HNHFMDCS) is an ambispective of patients with HFMD based in Henan Province, China, consisting treated a key hospital for the diagnosis treatment Province. aims to investigate long-term survivors provide comprehensive understanding potential harm caused by this infectious disease. Participants In retrospective phase study, children diagnosed from January 2014 2023 were included, clinical demographic information...
Traffic-related air pollution (TRAP) remains a concern for public health. However, the exact mechanisms through which TRAP affects respiratory system are still not fully understood. This study aimed to investigate nasal microbiome change in healthy adults after short-term exposure TRAP, contributing understanding of adverse health effects associated with TRAP. A randomized crossover controlled trial was conducted from 9 March 30 2024 among college students aged 19–24 years. Twenty were...
Abstract Fine particulate matter (PM 2.5 ) is a known risk factor for heart failure (HF), while plant-based dietary patterns may help reduce HF risk. This study examined the combined impact of PM exposure and diet on incidence. A total 190,092 participants from UK Biobank were included in this study. cases identified through linkage to National Health Services register, with follow-up lasting until October 2022 England, August Scotland, May Wales. Annual mean concentration was obtained using...
Enterovirus 71 (EV71) is associated with severe hand-foot-mouth disease. Recently, outbreaks of EV71 infection high mortality have been reported in the Asia-Pacific region, posing a great challenge for global public health.