A5055886549- Viral Infections and Immunology Research
- SARS-CoV-2 and COVID-19 Research
- COVID-19 epidemiological studies
- COVID-19 Clinical Research Studies
- Viral gastroenteritis research and epidemiology
- RNA regulation and disease
- Cardiac Fibrosis and Remodeling
- Animal Disease Management and Epidemiology
- Air Quality and Health Impacts
- Climate Change and Health Impacts
- interferon and immune responses
- COVID-19 and healthcare impacts
- COVID-19 and Mental Health
- Viral Infections and Outbreaks Research
- Hematopoietic Stem Cell Transplantation
- Acute Myeloid Leukemia Research
- Eosinophilic Disorders and Syndromes
- Peripheral Neuropathies and Disorders
- Influenza Virus Research Studies
- IL-33, ST2, and ILC Pathways
- COVID-19 impact on air quality
- Kawasaki Disease and Coronary Complications
- Immune Cell Function and Interaction
- Hydrogen's biological and therapeutic effects
- Hepatitis Viruses Studies and Epidemiology
Zhengzhou University
2020-2025
Zhengzhou Children's Hospital
2024
Purpose The childhood hand, foot and mouth disease (HFMD) sequelae cohort study (HNHFMDCS) is an ambispective of patients with HFMD based in Henan Province, China, consisting treated a key hospital for the diagnosis treatment Province. aims to investigate long-term survivors provide comprehensive understanding potential harm caused by this infectious disease. Participants In retrospective phase study, children diagnosed from January 2014 2023 were included, clinical demographic information...
CVA6 is one of Enteroviruses causing worldwide epidemics HFMD with neurological and systemic complications. A suitable animal model necessary for studying the pathogenesis evaluating antiviral vaccine efficacy. In this study, we generated a mouse-adapted strain that successfully infected 10-day-old ICR mice via oral route. All were paralyzed died within 11 dpi. Analysis pathological changes virus loads in fourteen tissues showed triggered systematic damage similar to i.p. inoculation Unlike...
To reduce the incidence of severe illness and fatalities, promote awareness protection precaution, increased vaccination, strengthen physical fitness, frequent ventilation, health education should be enhanced among vulnerable populations as essential measures for future control COVID-19.
Abstract Pulmonary edema that comes on suddenly is the leading cause of mortality in hand‐foot‐and‐mouth disease (HFMD) patients; however, its pathogenesis still largely unclear. A range research suggest immunopathogenesis during occurrence pulmonary severe HFMD patients. Herein, to investigate potential mechanism immune dysregulation development upon Enterovirus (EV) infection, we established mouse infection models for Enteroviruses (EVs) including Coxsackievirus (CV) A6, A71 (EVA71), and...
Coxsackievirus (CV) A2 has emerged as an important etiological agent in the pathogen spectrum of hand, foot, and mouth disease (HFMD). The symptoms CVA2 infections are generally mild, but worsen rapidly some people, posing a serious threat to children’s health. However, compared with enterovirus 71 detected frequently fatal cases, limited attention been paid because its benign clinical course. In present study, we identified three strains from HFMD used cell-adapted strain HN202009 inoculate...
Coxsackievirus A2 (CVA2) is an emerging pathogen that results in hand-foot-and-mouth disease (HFMD) outbreaks. Systemic inflammatory response and central nervous system inflammation are the main pathological features of fatal HFMD. However, immunopathogenesis CVA2 infection poorly understood. We first detected transcriptional levels 81 inflammation-related genes neonatal mice with infection. Remarkably, induced higher expression chemokine (C-X-C motif) ligand 10 (CXCL10) multiple organs...
Enterovirus A71 (EV-A71) is a common small RNA virus that highly neuroinvasive. Emerging evidence indicates the complement fragment C5a and its receptor C5aR1 are important drivers of neuroinflammation. However, potential role C5a-C5aR1 axis in EV-A71 encephalitis remains largely elusive. Our previous studies revealed can infect astrocytes result activation vivo. Here, we investigated how factors interact with to promote severe inflammatory response upon infection. data infected mainly...
Coxsackievirus A2 (CVA2) has emerged as an active pathogen that been implicated in hand, foot, and mouth disease (HFMD) herpangina outbreaks worldwide. It reported severe cases with CVA2 infection develop into heart injury, which may be one of the causes death. However, mechanisms CVA2-induced injury have not well understood. In this study, we used a neonatal mouse model to investigate possible injury. We detected replication apoptosis tissues from infected mice. The activity total aspartate...
ABSTRACTCoxsackievirus A19 (CVA19) is a member of Enterovirus (EV) C group in the Picornaviridae family. Recently, we reported case CVA19-infected hand, foot, and mouth disease (HFMD) for first time. However, current body knowledge on CVA19 infection, particularly pathogenesis encephalomyelitis diarrhoea still very limited, due to lack suitable animal models. Here, successfully established mouse model via oral route based 7-day-old ICR mice. Our results found virus strain could directly...
Abstract Coxsackievirus A6 (CVA6) is currently considered as a predominant pathogen of hand, foot, and mouth disease (HFMD), occasionally linked to myocardial injury. We first established mouse model CVA6-induced Next, we analyzed the immune cell phenotypes CVA6-infected mice hearts by fluorescence-activated sorting, found that CVA6 led massive neutrophils infiltration, suggesting their potential link with occurrence further used either αGr-1 or αLy6G antibody deplete neutrophils,...
Coxsackievirus (CV) A6 has emerged as an important causative agent in global outbreaks of hand, foot, and mouth disease (HFMD), which typically presents a mild illness with large generalized rash, herpes. However, some patients can develop encephalitis, pneumonia, myocarditis liver injury. Our previous study took the view that CVA6 could replicate mouse liver, leading to acute injury; however, precise underlying mechanism remains elusive. 10-day-old wild-type (WT, C57BL/6J) NLRP3 knock-out...
Objective: To analyze the characteristics of COVID-19 case spectrum and spread intensity in different provinces China except Hubei province. Methods: The daily incidence data information were collected from official websites provincial municipal health commissions. morbidity rate, severity case-fatality ratio calculated. Results: As 20 March, 2020, a total 12 941 cases had been conformed, including 116 deaths, average rate 0.97/100 000, 13.5% 0.90%, respectively. rates Zhejiang (2.12/100...
Abstract Background The incubation period is a key index of epidemiology in understanding the spread infectious diseases and decision-making disease control. However, emerging COVID-19 still unclear. Methods Between January 19, 2020 September 21, 2020, we collected information on 11545 patients Mainland China outside Hubei. 218 with precise data was validation population. fitted lognormal model by coarseDataTools package R. Results In patients, mean 7.1 days (95% Confidence interval [CI],...
Coxsackievirus A2 (CVA2) has recently been constantly detected, and is associated with viral myocarditis in children. Our previous study demonstrated that CVA2 led to heart damage a neonatal murine model. However, the molecular mechanism of injury caused by remains largely unknown. Emerging evidence suggests significant functions miRNAs infection. To investigate potential involved CVA2, our study, for first time, conducted RNA-seq vivo employing infected mice hearts. In total, 87, 101 76...
To investigate the roles of angiotensin-converting enzyme 2 (ACE2) in ozone-induced pulmonary inflammation and airway remodeling mice.Sixteen wild-type (WT) C57BL/6J mice 16 ACE2 knock-out (KO) were exposed to either filtered air or ozone (0.8 ppm) for 3 h per day 5 consecutive days. Masson's staining HE used observe lung pathologies. Bronchoalveolar lavage fluid (BALF) was collected total cell count determined. The proteins cytokines BALF determined by BCA ELISA method. transcription levels...
Abstract Background: Coronavirus Disease 2019 (COVID-19) has spread across China and the world, since outbreak at end of 2019. Although COVID-19 is generally considered as self-limiting, some cases develop in to fatal respiratory restress, multiple organ failure even sudden death. According data released by provincial health commissions, there are obvious regional differences mortality. To explore possible factors related severity mortality laboratory-confirmed from Henan Zhejiang.Methods:...