A5101858046- Ferroptosis and cancer prognosis
- Renal cell carcinoma treatment
- Glycosylation and Glycoproteins Research
- Cancer, Lipids, and Metabolism
- Neurological Disease Mechanisms and Treatments
- Peptidase Inhibition and Analysis
- Gastric Cancer Management and Outcomes
- Immunotherapy and Immune Responses
- Monoclonal and Polyclonal Antibodies Research
- Adenosine and Purinergic Signaling
- Cancer, Stress, Anesthesia, and Immune Response
- Carbohydrate Chemistry and Synthesis
- Cancer Immunotherapy and Biomarkers
- HIV/AIDS Research and Interventions
- HIV Research and Treatment
- Pancreatic function and diabetes
- Cancer Mechanisms and Therapy
- Heat shock proteins research
- Bioinformatics and Genomic Networks
- Protein Kinase Regulation and GTPase Signaling
- Flavonoids in Medical Research
- RNA regulation and disease
- Cell death mechanisms and regulation
- Bacteriophages and microbial interactions
- Anesthesia and Sedative Agents
Linyi University
2025
Ningxia Medical University
2023-2024
Zhengzhou University
2023
University of Florida
2019-2022
Wenzhou Medical University
2021-2022
First Affiliated Hospital of Wenzhou Medical University
2021-2022
Gainesville Obstetrics & Gynecology
2020
Army Medical University
2019
Soochow University
2019
Xinqiao Hospital
2019
The goal of this study was to assess risk factors associated with HIV/AIDS progression. Between May 2007 and December 2014, 114 subjects were enrolled in Wuxi City examined every 6 months. pol gene sequence amplified ascertain the HIV-1 subtype. A Cox proportional hazards regression model used estimate median follow-up time for all 26.70 months (IQR: 18.50-41.47), while progression 38 progressed 24.80 14.13-34.38). Overall, CRF01_AE subtype correlated a significant accelerated compared...
Papillary thyroid cancer (PTC) is the most common malignancy of endocrine system, with an increase in incidence frequency. Major vault protein (
B and T lymphocyte attenuator (BTLA) is a newly identified immune checkpoint molecular belonging to the CD28 immunoglobulin superfamily. However, expression clinical value of BTLA in skin cutaneous melanoma (SKCM) has not been widely characterized. We found that levels were upregulated metastatic compared normal tissues primary melanoma. Higher was also correlated with improved prognosis SKCM based on several datasets. The multivariate Cox regression model revealed an independent survival...
Previous studies on the antioxidant activity of sedatives have predominantly been in vitro investigations that are lacking clinical data, resulting conclusion without cogency. The aim present prospective, randomized study was to use single sedative drugs for anesthesia induction compare their properties. effects system midazolam, propofol and dexmedetomidine were assessed using oxidative stress indicators micronuclei (MN). Forty-nine patients undergoing esophageal cancer radical...
Glycosphingolipids (GSLs), including gangliosides, are essential components of the cell membrane. Because their vital biological functions, a facile method for analysis and comparison GSLs in issues is desired. To this end, new GSL was developed based on two-stage matching carbohydrate glycolipid product ions experimental reference MS/MS spectra GSLs. The applicability to gangliosides tissues verified using human plasma mouse brains spiked with standards. then used characterize endogenous...
To explore the mechanism of AP1S1 in breast cancer.In different datasets, we found that is more highly expressed tumors, which was furthermore verified our local cohort.Immune infiltration analysis showed related to a variety immune cells. The higher expression negatively correlated with infiltrating cells, suggesting may affect cellular immunity.Clinical patients had estrogen receptor gene and were prone distant metastasis lymph node metastasis.The overall survival rate, disease-specific...
Background: In the present study, we aimed to investigate effect of proviral integration site for moloney murine leukemia virus-1 (Pim-1) inhibitor (SMI-4a) on progression non-small cell lung cancer (NSCLC). Materials and methods: The effects SMI-4a proliferation, apoptosis, cycle NSCLC cells were examined by in vitro experiments using human lines (A549 Ltep-a-2). pathway regulated was detected Western blot. Furthermore, performed vivo assess tumor growth mouse models with NSCLC. Results:...
Two myo-inositol derivatives having an Nα,Nε-diacetyl-l-lysine (Ac2Lys) moiety linked to the inositol 1-O-position through a self-cleavable linker and metabolically stable 2-azidoethyl group 3-O- 4-O-positions, respectively, were designed synthesized. The Ac2Lys blocking required for GPI biosynthesis was expected be removable by combination of two enzymes, histone deacetylase (HDAC) cathepsin L (CTSL), abundantly expressed in cancer cells, but not normal transform these into biosynthetically...
To investigate the factors associated with sexually transmitted infection and Human Immunodeficiency Virus (STI-HIV) co-infection among men who have sex (MSM). A total of 357 HIV-infected participants (84 STI-HIV 273 HIV infections only) were recruited from Jiangsu, China. Logistic regression analyses used to estimate related co-infection. Marginal structural models adopted effect transmission drug resistance (TDR) on For all participants, logistic revealed that those diagnosed HIV-1 for...
Analogues of cancer-associated Lewis Y (Ley) antigen with varying structures at the reducing end were synthesized by a highly efficient strategy involving one-pot preactivation-based iterative glycosylation to obtain key tetra-/pentasaccharide intermediates, which was followed stereoselective fucosylation. After global deprotection, these oligosaccharides coupled carrier protein keyhole limpet hemocyanin. The resultant glycan-protein conjugates subjected immunological studies in mice. It...
Abstract Coxsackievirus A6 (CVA6) is currently considered as a predominant pathogen of hand, foot, and mouth disease (HFMD), occasionally linked to myocardial injury. We first established mouse model CVA6-induced Next, we analyzed the immune cell phenotypes CVA6-infected mice hearts by fluorescence-activated sorting, found that CVA6 led massive neutrophils infiltration, suggesting their potential link with occurrence further used either αGr-1 or αLy6G antibody deplete neutrophils,...
Lycium barbarum polysaccharide (LBP) is the main active component of Fructus Lycii, exhibiting various biological activities. This study aims to explore protective effects LBP on human corneal epithelial cells (HCEC) and a rat injury model. Potential target points for improving repair were screened from public databases, functional pathway enrichment analyses core targets conducted using Gene Ontology (GO) Kyoto Encyclopedia Genes Genomes (KEGG). Rat alkali burns HCEC oxidative stress models...
MSH-PE38KDEL is a chimeric molecule composed of MSH, and fused to truncated mutant form Pseudomonas exotoxin (PE38KDEL).Our study aims evaluate the specific cytotoxicity recombinant immunotoxin on melanoma cells A875 B16 in vitro, as well its inhibition metastatic vivo.MSH-PE38KDEL was expressed Escherichia coli, greater than 90% purity obtained.The purified found be selectively cytotoxic MSH receptor-positive vitro.The over 85% by cell viability assay; however, had no human 2BS cells.The...
Abstract Background Gan-song Yin (GSY) is originated from the scripture “Gan-song Pills”, a medical work of Ningxia ethnic minorities, and its treatment kidney diseases has good results. Its method treating Renal clear cell carcinoma (KIRC) still unknown, nevertheless. Methods Firstly, utilizing network pharmacology strategy to screen GSY for active components targets looking up KIRC-related in GeneCards GEO databases. Secondly, protein interaction networks were constructed analyzed GO KEGG...
Diabetic retinopathy (DR) is a common microvascular complication of diabetes mellitus. Its blindness rate high; therefore, finding reasonable and safe treatment plan to prevent control DR crucial. Currently, there are abundant diverse research results on the by Chinese medicine Traditional compounds potentially advantageous for prevention because its effective therapeutic effects.
Abstract Background Gan Song Drink (GSY) is originated from the scripture "Gan Pills", a medical work of Ningxia ethnic minorities, and its treatment kidney diseases has good results. Its method treating clear cell carcinoma (KIRC) still unknown, nevertheless. Methods Screening GSY for active ingredients targets using network pharmacology approach searching KIRC-related via Genecards GEO databases.Further construction protein interaction GO KEGG enrichment analyses were carried out. After...
Abstract Background: Gan-song Yin (GSY) is originated from the scripture "Gan-song Pills", a medical work of Ningxia ethnic minorities, and its treatment kidney diseases has good results. Its method treating Renal clear cell carcinoma (KIRC) still unknown, nevertheless. Methods: Firstly, utilizing network pharmacology strategy to screen GSY for active components targets looking up KIRC-related in GeneCards GEO databases. Secondly, protein interaction networks were constructed analyzed GO...