A5100445799- Cancer-related molecular mechanisms research
- RNA modifications and cancer
- Circular RNAs in diseases
- RNA Research and Splicing
- Cancer, Lipids, and Metabolism
- Cancer-related Molecular Pathways
- Cancer Treatment and Pharmacology
- Galectins and Cancer Biology
- Autophagy in Disease and Therapy
- Lymphoma Diagnosis and Treatment
- Bioactive Compounds and Antitumor Agents
- Microtubule and mitosis dynamics
- Ferroptosis and cancer prognosis
- Protease and Inhibitor Mechanisms
- Cytokine Signaling Pathways and Interactions
- Thyroid Cancer Diagnosis and Treatment
- Cancer Immunotherapy and Biomarkers
- MicroRNA in disease regulation
- Immunotherapy and Immune Responses
- Cancer Mechanisms and Therapy
- Breast Implant and Reconstruction
- Redox biology and oxidative stress
- CNS Lymphoma Diagnosis and Treatment
- Genetic Syndromes and Imprinting
- Thyroid and Parathyroid Surgery
First Affiliated Hospital of Wenzhou Medical University
2012-2023
Wenzhou Medical University
2013-2023
Second Affiliated Hospital of Jilin University
2023
Army Medical University
2022
Daping Hospital
2022
Xi'an Medical University
2021
Expression profile analysis of long noncoding RNA in HER-2-enriched subtype breast cancer by next-generation sequencing and bioinformatics Fan Yang, Shixu Lyu, Siyang Dong, Yehuan Liu, Xiaohua Zhang, Ouchen Wang Department Surgical Oncology, The First Affiliated Hospital Wenzhou Medical University, Wenzhou, Zhejiang, People's Republic China Background: Human epidermal growth factor receptor 2 (HER-2)-enriched is associated with a more aggressive phenotype shorter survival time. Long RNAs...
Triple-negative breast cancer (TNBC) is an aggressive subgroup of human cancer. Patients with TNBC have poor clinical outcome as they are non-responsive to current targeted therapies. There urgent need identify new therapeutic targets and develop more effective treatment options for patients. Osthole, a natural product from C. monnieri, has been shown inhibit certain cells. However, the mechanisms action well its effect on cells not currently known.We investigated osthole in cultured...
The CD44 isoform containing variant exon v6 (CD44v6) plays an important role in the progression, metastasis, and prognosis of colorectal cancer (CRC). Recently, it was found that CD44v6 is involved acquired drug resistance. This study aimed to investigate molecular mechanism resistance CRC cells chemotherapy. A stable overexpression model SW480 established via lentiviral transduction. chemosensitivity 5-fluorouracil (5-FU) oxaliplatin (L-OHP) determined by cell counting kit (CCK)-8, lactate...
MicroRNA-27a (miR-27a) has been reported to be an onco-microRNA in multiple cancers promoting tumor growth and metastasis, but the role of miR-27a regulating cancer sensitivity chemotherapy remains unknown. In this study, upregulation was validated by real-time PCR analysis breast (BC) cell lines samples BC patients. A negative correlation between bak also observed normal epithelial line MCF-10A lines, suggesting that is potential target miR-27a. could modulate metastasis cells. More...
Background and Purpose Gastric cancer is one of the leading causes morbidity mortality worldwide. Akt an anti‐apoptotic kinase that plays a dynamic role in cell survival implicated pathogenesis gastric cancer. MK‐2206, first allosteric inhibitor Akt, clinical trials for number cancers. Although preclinical studies showed promise, reported it had no effect when given alone at tolerated doses. The aim our study was to delineate effects MK‐2206 on cells explore ability combination treatments...
Luminal subtype breast cancer accounts for a predominant number of cancers. Considering the heterogeneity disease, it is urgent to develop novel biomarkers improve risk stratification and optimize therapy choices. Long non-coding RNA (lncRNA) represents an emerging understudied class transcripts that play significant role in biology. Growing knowledge cancer-associated lncRNAs contributes development molecular markers prognosis evaluation gene therapy.Three pairs primary luminal tissues...
Abstract Triple‐negative breast cancer (TNBC) is a subtype of with poor clinical outcome and currently no effective targeted therapies are available. Alantolactone (ATL), sesquiterpene lactone, has been shown to have potential anti‐tumour activity against various cells. However, the underlying mechanism therapeutic effect ATL in TNBC largely unknown. In present study, we found that suppresses cell viability by reactive oxygen species (ROS) accumulation subsequent ROS‐dependent endoplasmic...
Tamoxifen and anastrozole are widely used as adjuvant treatment for early stage breast cancer, but their hepatotoxicity is not fully defined. We aimed to compare of with tamoxifen in the setting postmenopausal cancer patients. Three hundred fifty-three Chinese women hormone receptor-positive were randomized or after optimal primary therapy. The end-point was fatty liver disease, defined a liver-spleen ratio <0.9 determined using computed tomography scan. secondary end-points included...
Non–small cell lung cancer (NSCLC) accounts for approximately 80–85% of all cancers and is usually diagnosed at an advanced stage with poor prognosis. Targeted therapy has produced unprecedented outcomes in patients NSCLC as a number oncogenic drivers have been found. Crizotinib, selective small-molecule inhibitor, widely used the treatment ALK gene rearrangements. A recent study also shown that (S)-enantiomer crizotinib exhibits anticancer activity by targeting protein mutT homologue...
Breast cancer (BC) is the most frequent malignancy occurring in women worldwide. Emerging evidence indicates that small nucleolar RNAs (snoRNAs) play a role tumor development. In current study, we evaluated expression profiles and functions of snoRNAs associated with BC.We analyzed levels between breast normal tissues TCGA database found SNORA7B upregulated BC. We confirmed this result clinical BC cell lines via qRT-PCR. Then, investigated significance public datasets biological function...
Aging | doi:10.18632/aging.204967. Yufeng Qi, Haodong Wu, Tianru Zhu, Zitian Liu, Conghui Congzhi Yan, Zhixuan Yiying Xu, Ying Bai, Lehe Yang, Dezhi Cheng, Xiaohua Zhang, Haiyang Zhao, Chengguang Xuanxuan Dai
B and T lymphocyte attenuator (BTLA) is a newly identified immune checkpoint molecular belonging to the CD28 immunoglobulin superfamily. However, expression clinical value of BTLA in skin cutaneous melanoma (SKCM) has not been widely characterized. We found that levels were upregulated metastatic compared normal tissues primary melanoma. Higher was also correlated with improved prognosis SKCM based on several datasets. The multivariate Cox regression model revealed an independent survival...
PCA3 (prostate cancer antigen 3) gene is one of the most prostate cancer-specific genes at present. Consequently, prostate-specific expression and sharp up-regulation mRNA in suggest a unique transcriptional regulation, which possibly can be attributed to promoter polymorphism. In our study, we evaluated whether there polymorphism region also assess association with cancer.We designed specific primer set screen by polymerase chain reaction (PCR)-based cloning sequencing DNA extracted from...
Genomic instability (GI) is among the top ten characteristics of malignancy. Long non-coding RNAs (lncRNAs) are promising cancer biomarkers that reportedly involved in GI. So far, clinical value GI-related lncRNAs (GIlncs) papillary thyroid (PTC) has not been clarified.Integrative analysis lncRNA expression and somatic mutation profiles was performed to identify GIlncs. Analysis differentially expressed group with high- low- cumulative number mutations revealed significant GIlncs PTC....
Airway remodeling is a remarkable pathological characteristic of chronic obstructive pulmonary disease (COPD), and long noncoding RNAs have been demonstrated to participate in COPD development pathogenesis. Here, we investigate the role RNA GAS5 cigarette smoke (CS)-induced airway remodeling. expression significantly lower lung tissues CS-exposed mice than control without exposure CS. Forced overexpression suppresses CS-induced inflammation also inhibits CS extract-induced...
Papillary thyroid carcinoma (PTC) is the most common type of carcinoma, which associated with a high incidence lymph-node metastasis. Multiple biomarkers have been identified for precise diagnosis PTC at an early stage. However, their role in remains poorly elucidated. Previously, we reported that lipase H (LIPH), membrane-bound protein, was highly expressed PTC. This study aimed to fully elucidate causal LIPH development and investigated its relationship metastasis PTC.Quantitative reverse...