A5005659380- Prostate Cancer Treatment and Research
- Acute Myeloid Leukemia Research
- Acute Lymphoblastic Leukemia research
- Cancer-related molecular mechanisms research
- Prostate Cancer Diagnosis and Treatment
- Immune Cell Function and Interaction
- Radiopharmaceutical Chemistry and Applications
- Spondyloarthritis Studies and Treatments
- Epigenetics and DNA Methylation
- Microbial metabolism and enzyme function
- Hearing, Cochlea, Tinnitus, Genetics
- Childhood Cancer Survivors' Quality of Life
- Systemic Lupus Erythematosus Research
- Cancer-related cognitive impairment studies
- Macrophage Migration Inhibitory Factor
- Lymphoma Diagnosis and Treatment
- Myeloproliferative Neoplasms: Diagnosis and Treatment
- Reproductive tract infections research
- Kruppel-like factors research
- Cancer, Lipids, and Metabolism
- Retinoids in leukemia and cellular processes
- Cancer Research and Treatments
- Fungal Infections and Studies
- interferon and immune responses
- Syphilis Diagnosis and Treatment
First Affiliated Hospital of Wenzhou Medical University
2010-2023
Wenzhou Medical University
2010-2023
Abstract Background Recently, several studies have reported an association between lipid profiles and sudden sensorineural hearing loss (SSNHL), yet there is considerable variability the individual in defining precise serum lipids levels SSNHL. This study sought to identify a possible relationship dyslipidemia prevalence prognosis of Methods A case‐control was carried out at two independent medical centers, including 2,288 SSNHL patients healthy controls. Clinical characteristics parameters...
PCA3 (prostate cancer antigen 3) gene is one of the most prostate cancer-specific genes at present. Consequently, prostate-specific expression and sharp up-regulation mRNA in suggest a unique transcriptional regulation, which possibly can be attributed to promoter polymorphism. In our study, we evaluated whether there polymorphism region also assess association with cancer.We designed specific primer set screen by polymerase chain reaction (PCR)-based cloning sequencing DNA extracted from...
Despite the outstanding advances made over past decade regarding our knowledge of acute leukemia (AL), relapsed AL remains to be associated with a dismal prognosis. A better understanding relapse and monitoring D‑dimer lactate dehydrogenase (LDH) plasma levels following chemotherapy may aid clinicians in determining whether occur subsequent phases disease. The present study evaluated LDH 204 patients AL. Data were collected at initial onset AL, complete remission (CR) significantly increased...
To gain further insights into the predisposing risk factors for central nervous system (CNS) involvement in patients with acute lymphocytic leukemia (ALL), impact of CD56 expression these was investigated.We reviewed clinical features 588 consecutive ALL treated systemic chemotherapy regimens between 2000 and 2014. The categorical data from CD56+ were compared those CD56- patients.Among studied, 18.9% showed expression. significantly associated CD33+, CD10-, CD15+, TdT-, CD5+...
This study aimed to investigate the mechanisms underlying development of androgen-independent phenotype in prostate cancer. Methylation patterns were detected and androgen-dependent lymph node carcinoma (LNCaP) cells based on methylated DNA immunoprecipitation-bisulfite sequencing data differentially regions (DMRs) identified. Differentially expressed genes (DEGs) micro RNAs (miRNAs) with DMRs (named MDEGs MDEmiRNAs) identified by combining transcriptome methylation data, transcription...
Key Clinical Message To investigate an oncogenic mutation of SETBP 1 in the evolution from acute myelomonocytic leukemia (M4) to secondary aCML . data and molecular studies were analyzed paired 'normal' DNA a case with M4. We identified (encoding p.Asp868Ala alteration). The analysis sample indicated that was acquired during leukemic evolution.
The aim of this research was to estimate the expression interleukin-10 in acute lymphoblastic leukemia (ALL) patients before and after chemotherapy order evaluate its role as a marker disease progression.Flow cytometry used detect serum IL-10 levels ALL during chemotherapy. Patients were divided into either complete remission (CR) group non-remission (NR) group, B-ALL T-ALL WT-1 positive BCR-ABL1 group. changes concentration analyzed.IL-10 significantly elevated at onset disease, it also...
Objectives To explore the clinical significance of tyrosine kinase receptor RON mRNA expression and it's splicing variant in bladder tumors. Methods Sixty-three cases transitional cell carcinoma (TCCB), including 30 pathological grade I , 15 Ⅱ 18 Ⅲ (44 stage Tis + T1, T2 T3 +T4), 7 inverted papilloma ( IPB), 9 papillary urothelial neoplasm low malignant potential (PUNLMP) 12 normalbladder mucosa RT-PCR was employed with internal standard (GAPDHmRNA) to detect mRNA. PCR direct sequencing then...
Objective To study the relationship between valine/leucine247 (817G/T) polymorphism in exon 7 of apolipoprotein H (apoH) gene and generation antiphospholipid (APL)antibodies patients Han nationality with systemic lupus erythematosus (SLE) Wenzhou region.Methods This included 165 SLE 160 healthy controls region.Venous blood samples were obtained from all subjects followed by isolation plasma,sera white cells.PCR DNA sequencing carried out to assess Leu/Va1247 apoH gene.Lupus anticoagulant...
Background: The emergence of resistance to azithromycin complicates the treatment Neisseria gonorrhoeae, causative agent gonorrhea. Objectives: main objective this study was investigate impact mutations in different sites rplD gene on (AZM-R) and molecular characteristics N. gonorrhoeae. This aimed provide evidence for drug transmission. Methods: A total 37 isolates gonorrhoeae were collected within January 2018 December 2020. These obtained from urine, semen, or vaginal secretions patients....
Objective To establish a detection method based on DHPLC for determining the polymorphisms of PCA3 gene promoter.Methods Primers were designed amplification promoter gene.The cloning plasmids containing C_2T_6,C_2T_5,C_3T_5,C_2T_5/C_2T_6, C_3T_5/C_3T_4,C_3T_5/C_4T_5,C_3T_5/C_2T_5,C_3T_5/C_2T_6, C_3T_5/C_1T_8 C_2T_5/C_3T_4 and C_2T_6/C_2T_7 detected in our previous study,were used as reference.The polymorphism profiles promoters from established by optimized DHPLC.One hundred forty-seven out...