A5100456025- Particle physics theoretical and experimental studies
- Quantum Chromodynamics and Particle Interactions
- High-Energy Particle Collisions Research
- COVID-19 Clinical Research Studies
- SARS-CoV-2 and COVID-19 Research
- Autophagy in Disease and Therapy
- Clostridium difficile and Clostridium perfringens research
- Antifungal resistance and susceptibility
- Dark Matter and Cosmic Phenomena
- Pharmacological Effects of Natural Compounds
- Streptococcal Infections and Treatments
- Heme Oxygenase-1 and Carbon Monoxide
- Biosensors and Analytical Detection
- Animal Virus Infections Studies
- COVID-19 epidemiological studies
- Parasitic Diseases Research and Treatment
- Fungal Biology and Applications
- Long-Term Effects of COVID-19
- Viral Infections and Vectors
- Adipose Tissue and Metabolism
- SARS-CoV-2 detection and testing
- Reproductive tract infections research
- Insect symbiosis and bacterial influences
- Respiratory viral infections research
- Parasite Biology and Host Interactions
Nankai University
2024
Xian Center for Disease Control and Prevention
2024
Wenzhou Medical University
2016-2024
First Affiliated Hospital of Wenzhou Medical University
2016-2024
Peking University Shougang Hospital
2022-2024
Shaoxing People's Hospital
2024
Zhejiang University
2020-2024
Aerospace Center Hospital
2022-2024
Shandong University of Traditional Chinese Medicine
2024
Southwest Medical University
2023
Understanding the role and underlying regulation mechanism of autophagy in lipopolysaccharide-induced lung injury (LPS-LI) may provide potentially new pharmacological targets for treatment acute injury. The aim this study was to investigate functional significance LPS-LI. human pulmonary microvascular endothelial cells (HPMVECs) mice inhibited before they were challenged with LPS. In vitro, permeability, vitality, LDH release rate detected, zonula occluden-1 (ZO-1) expression stress fiber...
Abstract Background Although people of all ages are susceptible to the novel coronavirus infection, which is presently named “Coronavirus Disease 2019” (COVID-19), there has been relatively few cases reported among children. Therefore, it necessary understand clinical characteristics COVID-19 in children and differences from adults. Case presentation We report one pediatric case COVID-19. A 14-month-old boy was admitted hospital with a symptom fever, diagnosed mild form The child’s mother...
Acute lung injury (ALI) is a condition characterized by inflammation and oxidative damage. 3-methyladenine (3-MA) has great potential for regulating apoptosis, but its regulatory role in ALI unknown.
Background/Aims: Ischemia is one of the main causes high rate absorption transplanted autologous fat. Autophagy allows cells to survive by providing energy under starvation. Rapamycin has been found play a role in promoting autophagy. In this study, we investigated whether rapamycin participates survival and adipogenesis ischemia-challenged adipose-derived stem (ADSCs) regulating Methods: Before were exposed oxygen-glucose deprivation (OGD), simulated ischemic microenvironment, level...
Since the first report of blaNDM-1, 16 blaNDM variants have been identified among Gram-negative bacteria worldwide. Recently, a novel variant, blaNDM-13, was in chromosome an ST101 Escherichia coli isolate from Nepal. Here we reported plasmid-mediated blaNDM-13 carbapenem-resistant E. ST5138 clinical associated with hospital-acquired urinary tract infection China. and blaSHV-12 coexisted on ~54 Kb self-transferable plasmid. Compared NDM-1, NDM-13, NDM-3 NDM-4 had two amino acid substitutions...
Tumor necrosis factor receptor-associated 3 (TRAF3) has specific regulatory effects on a wide range of diseases, including tumors. However, the effect and mechanism TRAF3 lung adenocarcinoma (LUAD) are still unknown. The aim present study was to make clear role potential in LUAD.TIMER2.0 database western blot were applied detect expression tissue. Kaplan-Meier Plotter utilized explore clinical prognosis patients. Specific siRNA used inhibit LUAD cells (A549 H1299). CCK-8 EdU assays performed...
Integrin αvβ5 mediates pulmonary endothelial barrier function and acute lung injury (LI), but its roles in cell apoptosis autophagy are unclear. Thus, the aims of this study were to investigate significance ischemia-reperfusion (I/R)-induced LI explore relationship between autophagy. Human microvascular cells (HPMVECs) pretreated with an αvβ5-blocking antibody (ALULA) challenged oxygen-glucose deprivation/oxygen-glucose restoration, which mimics I/R; then, cellular detected, permeability was...
BackgroundDespite the increasing reports of re-positive SARS-CoV-2 cases after recovery and discharge from hospitals, our knowledge remains very limited regarding contributing factors re-positivity its roles in transmission epidemiology Omicron variant.MethodsIn this retrospective study, is defined as positive nucleic acid result (Ct < 35) following two consecutive negative results during hospitalization. A total 751 patients Shanghai Shelter Cabin Hospital were enrolled divided with a ratio...
Epidemiological evidence suggests that patients with hypertension infected severe acute respiratory syndrome Coronavirus 2 (SARS-CoV-2) are at increased risk of lung injury. However, it is still not clear whether this related to the usage renin-angiotensin system (RAS) blockers. We collected medical records coronavirus disease 2019 (COVID-19) from First Affiliated Hospital, Zhejiang University School Medicine (Hangzhou, China), and evaluated potential impact an angiotensin II receptor...
T helper 17 (Th17) lymphocytes play an important role in Aspergillus adaptive immune response against fumigatus, but there is little attention focused on the different types of immunosuppressive models which invasive pulmonary aspergillosis (IPA) develops. In addition, expression levels signal transducer and activator transcription 3 (STAT3)/retinoic acid-related orphan nuclear receptor gamma (RORγt)/interleukin (IL)-17A signaling pathway, involved regulation Th17 cells, as well whether are...
Background: The SARS-CoV-2 epidemic is currently spreading across the world. A better knowledge of viral loads at different stages disease progression would help inform clinical management and prevent nosocomial transmission. Methods: More than 3,000 respiratory, stool, serum urine samples were collected from 96 laboratory-confirmed COVID-19 patients. RNA load was measured, relationship between data severity analyzed. Findings: All patients confirmed by testing respiratory specimens, 54.22%...
Background CoronaVac has been authorized worldwide for preventing coronavirus disease 2019. Information on the safety, immunogenicity and consistency of different lots workshops is presented here. Methods In this randomized, double-blind, phase IV clinical trial in healthy children adolescents aged 3-17 years, we aimed to assess lot-to-lot workshop-to-workshop consistency, as well safety seven commercial-scale from three workshops. Eligible participants were enrolled into age cohorts (3-5,...
Objectives To evaluate the safety, toleration, and pharmacokinetics (PKs) comparison of two intravenous voriconazole formulations after three ascending dose administrations in healthy Chinese subjects. Methods A randomized, double-blind, placebo- positive-controlled trial was conducted cohorts with a total 42 Every cohort 14 subjects allocated proportion (8:4:2) to test formulation, positive or placebo successively by single first then multiple administration 3 mg/kg, 4 6 mg/kg. Key findings...
Aspergillus peritonitis is a rare but highly severe complication of peritoneal dialysis with high mortality rate. We report case fumigatus peritonitis. Despite early removal the catheter and oral voriconazole antifungal treatment for 3 weeks, effect was unsatisfactory, resulting in prolonged hospital stay affecting patient's quality life. After switching to liposomalAmphotericin B, inflammation indicators rapidly decreased infection controlled. Liposomalamphotericin B provides an option
Abstract Disclosure: X. Shen: None. M. Génard-Walton: P.L. Williams: T. James-Todd: J.B. Ford: K.M. Rexrode: D. Zhang: J.E. Chavarro: R.B. Hauser: L. Minguez Alarcon: Given the limited evidence on endocrine-disrupting chemicals (EDCs), evaluated as mixture, in relation to lipid biomarkers during pregnancy, we examined whether mixtures of urinary concentrations bisphenol A (BPA), parabens and phthalate metabolites were associated with serum levels among 175 pregnant women who enrolled...