A5109670010- Lung Cancer Treatments and Mutations
- Cancer Immunotherapy and Biomarkers
- Lung Cancer Research Studies
- Cancer Genomics and Diagnostics
- Antifungal resistance and susceptibility
- Fungal Infections and Studies
- Immune cells in cancer
- Advanced Sensor and Energy Harvesting Materials
- Inflammatory Biomarkers in Disease Prognosis
- Infectious Diseases and Mycology
- Ubiquitin and proteasome pathways
- Corrosion Behavior and Inhibition
- Advanced Materials and Mechanics
- Mycobacterium research and diagnosis
- Nanoplatforms for cancer theranostics
- Water Resources and Management
- Immune Cell Function and Interaction
- Transboundary Water Resource Management
- Platelet Disorders and Treatments
- Pleural and Pulmonary Diseases
- Multiple Myeloma Research and Treatments
- Polymer Surface Interaction Studies
- Nail Diseases and Treatments
- Chronic Lymphocytic Leukemia Research
- Advanced Nanomaterials in Catalysis
Nanyang Technological University
2024-2025
First Affiliated Hospital of Wenzhou Medical University
2016-2024
Wenzhou Medical University
2016-2024
Fudan University
2017
PLA Information Engineering University
2016
Bio-inspired fibrillar adhesives have received worldwide attention but their potentials been limited by a trade-off between adhesion strength and switchability, size scale effect that restricts the fibrils to micro/nanoscales. Here, we report class of adhesive achieve unprecedented (∼2 MPa), switchability (∼2000), scalability (up millimeter-scale at single fibril level), leveraging rubber-to-glass (R2G) transition in shape memory polymers (SMPs). Moreover, R2G SMP arrays exhibit >1000 (with...
Achieving high-quality biopotential signal recordings requires soft and stable interfaces between tissues bioelectronic devices. Traditional bioelectronics, typically rigid dependent on medical tape or sutures, lead to mechanical mismatches inflammatory responses. Existing conducting polymer-based bioelectronics offer tissue-like softness but lack intrinsic adhesion, limiting their effectiveness in creating stable, conductive interfaces. Here, we present an intrinsically adhesive hydrogel...
Background Urinary incontinence (UI) is a common and troublesome global problem. The purpose was to explore the relationship between muscle quality index (MQI) UI. Methods We performed secondary analysis of National Health Nutrition Examination Survey (NHANES) database (2011 2014). Weighted logistic regression used analyze MQI Subgroup analyses were further conducted investigate relationship. P for trend interaction also conducted. Results A total 2,779 participants enrolled in study,...
Background Circulating tumor DNA (ctDNA) is a promising biomarker for noninvasive epidermal growth factor receptor (EGFR) mutations detection in lung cancer patients, but the existing methods have limitations sensitivity or availability. In this study, we evaluated performance of novel assay called ADx-SuperARMS detecting EGFR plasma cell-free from patients with advanced adenocarcinoma. Methods A total 109 metastatic adenocarcinoma were recruited who provided both blood samples and matched...
Clinicians may fail to make an early diagnosis of pulmonary cryptococcosis (PC) without HIV infection. Serum cryptococcal capsular polysaccharide antigen (CrAg) test, histopathology and culture lung tissue play different roles in PC.To investigate the performance serum CrAg PC infection.From January 2011 September 2017, patients with proven were recruited from a teaching hospital southern China. Those infection, confirmed by surgery or probable possible excluded study. Latex agglutination...
// Qiang Zhuang 1 , Lina Xiang 2 Hanyan Xu 3 Fang Chongyun Xing Bin Liang Kang Yu Jianhua Feng 1, 4 Department of Hematology, The First Affiliated Hospital Wenzhou Medical University, 325000, PR China Emergency Medicine, Pneumology, Pediatric Hematology-Oncology, Correspondence to: Feng, email: wzfjh@126.com Keywords: multiple myeloma, mean platelet volume, prognosis, survival Received: April 20, 2016 Accepted: August 13, Published: 23, ABSTRACT We retrospectively analyzed the association...
Abstract Adipose-derived stem cells (ADSCs) have been shown to be beneficial in some pulmonary diseases, and the paracrine effect is major mechanism underlying ADSC-based therapy. Autophagy plays a crucial role maintaining cell homeostasis survival. However, of autophagy mediating ADSC effects has not thoroughly elucidated. We examined whether ADSCs participate lipopolysaccharide (LPS)-induced microvascular endothelial (PMVEC) barrier damage manner illuminated regulating effects. PMVECs with...
The aim of this study was to identify the optimal cut-off value T cell enzyme-linked immunospot assay for tuberculosis (T-SPOT.TB) and evaluate its diagnostic performance alone (in peripheral blood) or in combination with adenosine deaminase (ADA) activity test blood pleural fluid) patients tuberculous pleurisy.Adult presenting effusion were included prospective cohort study. Tuberculous pleurisy diagnosed by T-SPOT.TB a ADA fluid blood. Receiver operating characteristic (ROC) curve...
Patients with high-titer anti-IFN-γ autoantibodies present disseminated non-tuberculous mycobacterial (NTM) and other opportunistic infections. Due to its rare occurrence non-specific symptoms, this syndrome is difficult diagnose during early disease stages. Here, we report a case high-concentrations of serum who presented Talaromyces marneffei NTM accompanied Sweet's syndrome.A 62-year-old Chinese woman no previous history was admitted our hospital in August 2016 due intermittent fever for...
Abstract The Aral Sea crisis is the most prominent environmental problem in building Silk Road and Economic Belt, which mainly induced by extensive exploitation of land resources basin since middle last century. upstream part Amu Darya River, as main water source Sea, almost entirely located Tajikistan, thus, development utilization Tajikistan affect whole basin. author puts forward oriented-development green energy under overall framework co-building developing small hydro-power dam-free...
Previous studies have shown that there are different methods used to detect the epidermal growth factor receptor (EGFR) mutation status in plasma cell-free DNA (cfDNA) for advanced lung adenocarcinoma patients including ADx-Amplification Refractory Mutation System (ADx-ARMS). We explored performance of ADx-ARMS detecting EGFR mutations cfDNA.This prospective cohort study enrolled who presented with (stage IIIb/IV) adenocarcinoma. cfDNA and tumor tissues by were detected. Next-generation...
Li-Fraumeni syndrome (LFS) and Li-Fraumeni-like (LFL) are rare hereditary diseases characterized by predisposition to a diverse spectrum of cancer types, primarily sarcoma. The pathogenic variants underlying the majority LFL cases remain be explored.We performed whole-exome sequencing (WES) on 13 core members large family with highly aggregated incidences cancers, including sarcoma, non-small cell lung cardiac angiosarcoma, conducted comprehensive literature review candidate gene...
Abstract Background Programmed death ligand 1 (PD‐L1) has been used as a diagnostic marker to identify patients that will benefit from immune checkpoint inhibitors in non‐small cell lung cancer (NSCLC). Immunohistochemistry with E1L3N clone is one of the most widely and inexpensive laboratory‐developed tests for PD‐L1, but still need be compared validated standard methods clinical application. Methods We investigated performance PD‐L1 testing 299 tumor tissues NSCLC its comparability...
T helper 17 (Th17) lymphocytes play an important role in Aspergillus adaptive immune response against fumigatus, but there is little attention focused on the different types of immunosuppressive models which invasive pulmonary aspergillosis (IPA) develops. In addition, expression levels signal transducer and activator transcription 3 (STAT3)/retinoic acid-related orphan nuclear receptor gamma (RORγt)/interleukin (IL)-17A signaling pathway, involved regulation Th17 cells, as well whether are...
Peptides and their conjugates are appealing as molecular scaffolds for constructing supramolecular biomaterials from the bottom up. Through strategic sequence design interaction modulation, these peptides can self-assemble into diverse nanostructures that can, in turn, mimic structural catalytic functions of contemporary proteins. Here, inspired by histidine brace active site identified metalloenzyme, we developed a triblock polypeptide with hydrophobic polyleucine segment, hydrophilic...
This study investigates the influence of different anions on hydration states and conformational changes poly(sulfobetaine methacrylate) (PSBMA) brushes, unraveling their intricate role in modulating tribomechanical properties antifouling performance. Through bimodal atomic force microscopy (AFM), we reveal that anion identity affects layered structure thicknesses PSBMA brushes accordance with Hofmeister series. Enhanced screening dipole–dipole interactions increased were observed higher...
<title>Abstract</title> Immune checkpoint inhibitors (ICIs) plus chemotherapy have become the first-line standard therapy for patients with gene-negative advanced non-small cell lung cancer (NSCLC). There is a lack of reliable biomarkers to predict treatment outcomes. This study aimed identify relevant lipids that can outcomes in NSCLC receiving ICIs via lipidomics. Plasma samples were collected from Forty-nine stage IIIB/IV before start treatment, and categorized into long-term benefit...
Association between the modified lung immune predictive index and clinical outcomes of advanced non-small cell cancer treated with first-line checkpoint inhibitors combined chemotherapy
Several approaches to the detection of T790M mutations in patient plasma or tissue samples have been implemented date. The present study was designed assess ability different technologies detect mutation and evaluate relative rates re-biopsy subsequent management a clinical setting. Data from patients with advanced NSCLC who visited Department Respiratory Medicine First Hospital Affiliated Wenzhou Medical University between December 2014 July 2018 were retrospectively collected. Following...
Hilar masses with stenosis of the bronchus occur mainly due to malignant diseases, such as lung cancer. resulting from invasive aspergillosis are extremely rare and mostly in severely immunosuppressed patients.In current case report, we have documented a unique presenting mass hilum bronchial under bronchoscopy mimicking cancer 54-year-old man diabetes mellitus. The histological analysis membrane biopsy demonstrated fungal elements 45° branching hyphae positive Periodic Acid-Schiff Grocott...
The 2D simulation project is a core competition of RoboCup Soccer League, which requires the developer to exploit multiple intelligent programs in assigned platform and let them act as players independently make up football team fight against others competition. There are already amount fatal data remained such programs, contest log so on. However, at present evaluation collection teams well their features still stay manual stage, causing subjective factors have great influence. This thesis...