A5100736469- Bone Tissue Engineering Materials
- RNA Interference and Gene Delivery
- Electrospun Nanofibers in Biomedical Applications
- Wound Healing and Treatments
- Mesenchymal stem cell research
- 3D Printing in Biomedical Research
- Graphene and Nanomaterials Applications
- MicroRNA in disease regulation
- Angiogenesis and VEGF in Cancer
- Nanoparticle-Based Drug Delivery
- Advanced Antenna and Metasurface Technologies
- Electromagnetic wave absorption materials
- Neurogenesis and neuroplasticity mechanisms
- Nerve injury and regeneration
- Extracellular vesicles in disease
- Advanced biosensing and bioanalysis techniques
- RNA modifications and cancer
- Nanoplatforms for cancer theranostics
- Cancer-related molecular mechanisms research
- Cancer, Hypoxia, and Metabolism
- Tissue Engineering and Regenerative Medicine
- Dental Implant Techniques and Outcomes
- Hydrogels: synthesis, properties, applications
- Diabetic Foot Ulcer Assessment and Management
- Advanced Photocatalysis Techniques
Sun Yat-sen University
2016-2025
Sun Yat-sen Memorial Hospital
2020-2025
China University of Geosciences
2025
Hexi University
2025
Shanghai Clinical Research Center
2025
Key Laboratory of Guangdong Province
2017-2025
Xuzhou Medical College
2025
Linyi People's Hospital
2015-2025
Soochow University
2025
The First Affiliated Hospital, Sun Yat-sen University
2017-2024
The regeneration of articular cartilage, which scarcely shows innate self-healing ability, is a great challenge in clinical treatment. Stem cell-derived exosomes (SC-Exos), an important type extracellular nanovesicle, exhibit potential for cartilage to replace stem cell-based therapy. Cartilage often takes relatively long time and there currently no effective administration method durably retain at defect sites effectively exert their reparative effect. Therefore, this study, we exploited...
Abstract MicroRNAs (miRNAs) are being developed to enhance tissue regeneration. Here we show that a hyperbranched polymer with high miRNA-binding affinity and negligible cytotoxicity can self-assemble into nano-sized polyplexes ‘double-shell’ miRNA distribution transfection efficiency. These encapsulated in biodegradable microspheres enable controllable two-stage (polyplexes miRNA) delivery. The attached cell-free nanofibrous scaffolds spatially control the release of miR-26a. This...
This paper discusses the key considerations of CBDC design to balance benefits and risks presents best practices in from a global perspective. Using China’s as an illustration, this two-tier or multi-tier ledger proposes ten enablers mass adoption successful implementation. proposed allows central banks manage process flow, focus on monitoring control, without bearing all load exposing over-centralized risks. It concludes that will be primary tool future digital economy, countries are...
Abstract Hypertrophic scar (HS) considerably affects the appearance and causes tissue dysfunction in patients. The low bioavailability of 5-fluorouracil poses a challenge for HS treatment. Here we show separating microneedle (MN) consisting photo-crosslinked GelMA 5-FuA-Pep-MA prodrug response to high reactive oxygen species (ROS) levels overexpression matrix metalloproteinases (MMPs) pathological microenvironment. In vivo experiments female mice demonstrate that retention MN tips provides...
Bio-inspired fibrillar adhesives have received worldwide attention but their potentials been limited by a trade-off between adhesion strength and switchability, size scale effect that restricts the fibrils to micro/nanoscales. Here, we report class of adhesive achieve unprecedented (∼2 MPa), switchability (∼2000), scalability (up millimeter-scale at single fibril level), leveraging rubber-to-glass (R2G) transition in shape memory polymers (SMPs). Moreover, R2G SMP arrays exhibit >1000 (with...
Three-dimensional (3D) gelatin sponge (GS) scaffolds were constructed by ensheathing GS with a thin film of poly-(lactide- co-glycolide) (PLGA). Rat bone marrow-derived mesenchymal stem cells (MSCs) isolated, cultured, and then seeded to the scaffolds. Distribution cell growth, survival, proliferation within determined. Immunofluorescence Western blot analysis employed detect deposition fibronectin on day 3 7 culture. Scaffolds or without MSCs transplanted into transected rat spinal cord....
Extracellular vesicles (EVs) are complex ecosystems that can be derived from all body cells and circulated in the fluids. Characterizing tissue-cellular source contributing to circulating EVs provides biological information about cell or tissue of origin their functional states. However, relative proportion fluid has not been thoroughly characterized. Here, we developed an approach for digital quantification, called EV-origin, enables enumerating contribution plasma extracellular long RNA...
Previously we have demonstrated that a Rhodiola crenulata extract (RCE), containing potent antioxidant salidroside, promotes neurogenesis in the hippocampus of depressive rats. The current study was designed to further investigate protective effect RCE on rat model Alzheimer's disease (AD) induced by an intracerebroventricular injection streptozotocin (STZ), and determine whether this neuroprotective is antioxidative activity salidroside. Our results showed pretreatment with significantly...
Hydrogel-based wound dressings provided a moist microenvironment and local release of bioactive molecules. Single drug loading along with fast rates usually in hydrogel sheets limited their performance. Hence, uniform alginate/CaCO3 composite microparticles (∼430 μm) tunable compositions for sustainable pH-sensitivity were successfully fabricated using microfluidic technology. Due to the presence CaCO3 strong interactions alginate molecules, lyophilized reverted state after rehydration....
Abstract Injury of corpus cavernosa results in erectile dysfunction, but its treatment has been very difficult. Here we construct heparin-coated 3D-printed hydrogel scaffolds seeded with hypoxia inducible factor-1α (HIF-1α)-mutated muscle-derived stem cells (MDSCs) to develop bioengineered vascularized corpora. HIF-1α-mutated MDSCs significantly secrete various angiogenic factors regardless or normoxia. The biodegradable scaffolds, along MDSCs, are implanted into defects a rabbit model show...
Diabetic foot ulcer (DFU) caused by impaired wound healing is a common vascular complication of diabetes. The current study revealed that plasma levels pigment epithelium–derived factor (PEDF) were elevated in type 2 diabetic patients with DFU and db/db mice. To test whether PEDF contribute to skin wound-healing delay diabetes, endogenous was neutralized an anti-PEDF antibody Our results showed neutralization accelerated healing, increased angiogenesis the skin, improved functions numbers...
The process of wound healing is often accompanied by bacterial infection, which a serious threat to human health. abuse antibiotics in traditional therapy aggravates the resistance bacteria and gradually reduces therapeutic effect. Therefore, it important develop effective antibacterial dressings promote prevent infection. Photothermal (PTT) considered quick reliable method suppressing infections without developing drug resistance. unique network structure high water retention hydrogel help...
Abstract Reported herein is an active and durable CoN‐containing oxygen evolution reaction (OER) electrocatalyst which efficiently functions in a neutral medium (pH ≈7). The composite material (N, S)‐RGO@CoN synthesized by delicate atomic layer deposition (ALD) of CoN on nitrogen sulfur S) co‐doped reduced graphene oxide (RGO) substrate. Representative results the comprehensive study are: 1) flower‐like sphere RGO substrate prepared spray drying method features rich physical chemical...
Abstract A highly efficient, low-cost and environmentally friendly photocathode with long-term stability is the goal of practical solar hydrogen evolution applications. Here, we found that Cu 3 BiS film-based meets abovementioned requirements. The -based presents a remarkable onset potential over 0.9 V RHE excellent photoelectrochemical current densities (~7 mA/cm 2 under 0 ) appreciable 10-hour in neutral water solutions. This high directly results good unbiased operating photocurrent ~1.6...
Abstract Development of new therapeutic scaffolds to selectively destruct tumors under gentle conditions meanwhile promoting adipose tissue formation would be a promising strategy for clinical treatment breast cancer. Herein, stimuli‐responsive scaffold composed polyacrylic acid‐ g ‐polylactic acid (PAA‐ ‐PLLA) modified graphene oxide (GO) with cleavable bond in between (GO‐PAA‐ ‐PLLA), gambogic (GA), and polycaprolactone (PCL) is fabricated then preseeded on adipose‐derived stem cells...
Hollow nanostructured hosts are important scaffolds to achieve high sulfur loading, fast charge transfer, and conspicuous restraint of lithium polysulfides (LiPSs) shuttling in lithium-sulfur (Li-S) batteries. However, developing high-efficiency hollow for improving utilization conversion aggregated the chamber remains a longstanding challenge. Herein, N-doped carbon nanocubes confined petal-like ZnS/SnS2 heterostructures (ZnS/SnS2 @NC) as conceptually novel host Li-S batteries reported....
Abstract In 3D (bio)printing, it is critical to optimize the printing conditions obtain scaffolds with designed structures and good uniformities. Traditional approaches for optimizing parameters oftentimes rely on prior knowledge of operators tedious optimization experiments, which can be both time‐consuming labor‐intensive. Moreover, rapid increase in types biomaterial inks geometrical complexities fabricated, such a traditional strategy may prove less effective. To address challenge, an...