A5112401566- Neurofibromatosis and Schwannoma Cases
- Nonmelanoma Skin Cancer Studies
- Gastric Cancer Management and Outcomes
- Advanced Fluorescence Microscopy Techniques
- Optical Coherence Tomography Applications
- Glioma Diagnosis and Treatment
- Acute Ischemic Stroke Management
- Healthcare Policy and Management
- Sexual function and dysfunction studies
- Spectroscopy Techniques in Biomedical and Chemical Research
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Cutaneous Melanoma Detection and Management
- Cancer Mechanisms and Therapy
- Connexins and lens biology
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Effects and risks of endocrine disrupting chemicals
- Sphingolipid Metabolism and Signaling
- Plant Pathogens and Fungal Diseases
- Infectious Diseases and Mycology
- Calpain Protease Function and Regulation
- Hydrogen's biological and therapeutic effects
- Reproductive Biology and Fertility
- Technology and Data Analysis
- Neuroblastoma Research and Treatments
- Melanoma and MAPK Pathways
University of Macau
2025
Shenzhen Institutes of Advanced Technology
2022-2025
Wenzhou Medical University
2024
First Affiliated Hospital of Wenzhou Medical University
2024
China Agricultural University
2024
Anhui Medical University
2023
Wenzhou-Kean University
2023
Chinese Academy of Sciences
2022
Ningxia Medical University
2019-2020
Christopher Newport University
2017
Multimodal optical microscopy can be used to visualize multiple biological targets at the same location and similar spatial resolutions, enabling more comprehensive studies of complex samples. However, current multimodal imaging systems typically use or specially designed excitation lasers. Furthermore, previous have reported only three four types modalities, limiting number targets. This study develops an system based on a single commercialized 1550 nm fiber laser integrates five...
Acute lung injury (ALI) is a condition characterized by inflammation and oxidative damage. 3-methyladenine (3-MA) has great potential for regulating apoptosis, but its regulatory role in ALI unknown.
Two-photon excitation fluorescence microscopy (TPM), owing to its capacity for subcellular resolution, intrinsic optical sectioning, and superior penetration depth in turbid samples, has revolutionized biomedical research. However, layer-by-layer scanning form a three-dimensional image inherently limits the volumetric imaging speed increases phototoxicity significantly. In this study, we develop gradient technique accelerate TPM imaging. The axial positions of fluorophores can be decoded...
Exposure to bisphenol A (BPA) has been shown increase the prevalence of obesity and its related insulin resistance (IR). Ceramide is a sphingolipid known facilitate production proinflammatory cytokines subsequently exacerbate inflammation IR during progression obesity. Here, we investigated effects BPA exposure on ceramide de novo synthesis whether increased ceramides aggravate adipose tissue (AT) obesity-related IR.
Although the role of asialoglycoprotein receptor 1 (ASGR1) in lowering lipid levels is well established, recent studies indicate that ASGR1 inhibition can cause unexpected liver damage pigs, raising a serious issue about whether be good target for treating ASCVD. Here, we utilized CRISPR-Cas9 system to regenerate ASGR1-knockout who displayed decreased profiles without observable damage. This was confirmed by lower serum ALT and AST, reduced expression inflammation markers, normal...
The United States spends nearly twice as much per capita on health care several OECD countries. Based previous research, universal decreases the total expenditure due to single-payer system; it is still unknown whether a mixed system has superiority. In this study, we compare and evaluate both quality of administrative costs among six developed countries, upon three groups: (Australia Canada), two-tier (France Japan), insurance mandate (Switzerland US). results show that are superior...
Objective To investigate the effects of intravenous injection α-crystallin on retinal ganglion cells (RGC) and some important organs Long Evans rats. Methods RGC were retrogradelabeled by fluorogold through bilateral superior colliculus lateral geniculate body for seven days before optic nerve crush injury. Twenty-three rats used this study, including three normal control group 20 experimental group. Twenty randomly divided into saline groups, which received tail vein 1.25 ml isotonic...
With the objective of investigating characteristics influencing high-risk sexual behaviours in elderly men (60-74 years age) Chongqing, China, a total 1433 healthy with intercourse frequencies one to six times/month who were willing participate questionnaires studied at four hospitals. We measured serum testosterone levels and performed follow-ups every months, 1128 followed up after two years. also investigated socio-economic demographic (age, education, income, location, marital status...
Objective To explore the phenomenon of spontaneous regression optic pathway glioma in children, and to improve understanding glioma. Methods The clinical data 3 patients with Beijing Children's Hospital Capital Medical University from September 2012 June 2019 were retrospectively analyzed. Results There 2 girls 1 boy among patients. The median age onset was 4 months (3-5 months), tumor 10 (8-13 interval time 5 (4-10 months). One patient accompanied diencephalic syndrome, other...
Objective To study the therapeutic value of endoscopy for secondary prophylaxis esophagogastricvariceal bleeding(EGVB). Methods Records 117 patients with EGVB who were treated endoscopic ligation and/or histoacryl injection (n=55) and devascularization(n=62) from August 2006 to September 2014 reviewed. Rebleeding rate, time rebleeding, incidence complication, cumulative survival length ward stay mean total costs compared between two groups. Indices according...
Objective To investigate effects of α-crystallin on proliferation lipopolysaccharide (LPS)-activated retinal microglia and bioactivity iNOS.Methods The microglial cells cultured in vitro were analyzed their purity was identified by cell immunofluorescence flow cytometry.After being intervened using LPS at various concentrations,influence activity LPS-activated detected MTT method level NO measured RT-PCR to observe changes iNOS expression microglia.Results Purity primary 94.15％ GSA-IB4...
Abstract Background Upper gastrointestinal cancers are the leading causes of cancer-related deaths in Northwest China and share many similarities terms histological type, risk factors genetic variants. We hypothesized that shared common SNPs among eight p53 pathway existed Ningxia gastric cancer (GC) esophageal (EC) patients. Methods A total 180 GC cases, 113 EC cases 358 cancer-free control subjects from a high-incidence area for upper Ningxia, China, were enrolled this study. The...
Objective To explore the clinical treatment outcomes of optic pathway glioma in children with diencephalic syndrome. Methods The data 8 cases syndrome were analyzed retrospectively who admitted to Department Neurosurgery, Beijing Children′s Hospital, Capital Medical University from July 2015 December 2018. The range children′s ages was 8.0 42.2 months. No weight gain reported all those patients before age 1 year, and they showed a cachexia state extreme emaciation at admission....
Abstract Objective : To investigate the effects of sex disparities on clinicopathological characteristics and prognosis 3937 Chinese gastric cancer (GC) patients. Materials methods A total patients, including 3098 males (78.7%) 839 females (21.3%), diagnosed with GC at General Hospital Ningxia Medical University China were selected through inclusion exclusion criteria, patients was followed up. Clinicopathological features assessed, univariate multivariate survival analyses performed....