A5087618113- Gestational Diabetes Research and Management
- Birth, Development, and Health
- Fatty Acid Research and Health
- Pregnancy and preeclampsia studies
- Metabolomics and Mass Spectrometry Studies
- Obesity, Physical Activity, Diet
- Breastfeeding Practices and Influences
- Gut microbiota and health
- Genomics and Phylogenetic Studies
- Epigenetics and DNA Methylation
- Antibiotic Resistance in Bacteria
- Diabetes, Cardiovascular Risks, and Lipoproteins
- Liver Disease Diagnosis and Treatment
- Metabolism and Genetic Disorders
- Bariatric Surgery and Outcomes
- Diphtheria, Corynebacterium, and Tetanus
- Escherichia coli research studies
- Adipose Tissue and Metabolism
- Nutritional Studies and Diet
- Plant and Fungal Species Descriptions
- Vitamin D Research Studies
- Ovarian function and disorders
- Peroxisome Proliferator-Activated Receptors
- Plant Gene Expression Analysis
- Adipokines, Inflammation, and Metabolic Diseases
Zhejiang University
2022-2025
Shady Grove Fertility Center
2025
Anhui University of Traditional Chinese Medicine
2021-2024
Glotech (United States)
2017-2024
Central South University
2009-2023
Fujian Medical University
2023
National Heart Lung and Blood Institute
2023
Southern Medical University
2017-2023
Huazhong University of Science and Technology
2023
Chinese Academy of Agricultural Sciences
2023
Changes in the microbial community structure are observed individuals with intestinal inflammatory disorders. These changes often characterized by a depletion of obligate anaerobic bacteria, whereas relative abundance facultative Enterobacteriaceae increases. The mechanisms which host response shapes structure, however, remain unknown. We show that nitrate generated as by-product conferred growth advantage to commensal bacterium Escherichia coli large intestine mice. Mice deficient inducible...
Abstract Gut dysbiosis has been linked to type 1 diabetes (T1D); however, microbial capacity in T1D remains unclear. Here, we integratively profiled gut functional and metabolic alterations children with new-onset independent cohorts investigated the underlying mechanisms. In T1D, microbiota was characterized by decreased butyrate production bile acid metabolism increased lipopolysaccharide biosynthesis at species, gene, metabolite levels. The combination of 18 bacterial species fecal...
Despite dietary recommendations of polyunsaturated fatty acids (PUFAs) for cardiometabolic health, n-3 and n-6 PUFAs their interplay in relation to diabetes risk remain debated. Importantly, data among pregnant women are scarce. We investigated individual plasma phospholipid early midpregnancy subsequent gestational mellitus (GDM).Within the National Institute Child Health Human Development (NICHD) Fetal Growth Studies-Singleton Cohort (n = 2,802), levels were measured at weeks (GWs) 10-14,...
Abnormal lipid profiles have been associated with gestational diabetes mellitus (GDM), but studies longitudinal measures of lipids throughout pregnancy are sparse. The aim the present study was to characterize changes in and prospectively examine associations plasma concentrations risk GDM.This a nested case-control including 107 GDM cases 214 matched non-GDM controls from participants National Institute Child Health Human Development (NICHD) Fetal Growth Studies - Singleton cohort. Blood...
Objectives Sequence type (ST) 1193 is emerging as a new, virulent and resistant lineage among fluoroquinolone Escherichia coli (FQr E. coli). In this study, we investigated the prevalence molecular characteristics of clone isolated from Chinese university hospital. Methods 73 phylogenetic group B2-FQr-non-ST131 isolates were collected August 2014 2015 at Isolates screened for ST1193 by Multilocus sequence typing (MLST). then underwent lactose fermentation determination, susceptibility...
Abstract Aim To prospectively and longitudinally investigate vitamin D status during early to mid‐pregnancy in relation gestational diabetes mellitus (GDM) risk. Methods In a nested case‐control study of 107 GDM cases 214 controls within the Fetal Growth Studies‐Singleton Cohort, plasma levels 25‐hydroxyvitamin D2 D3 (25(OH)D) binding protein were measured at weeks 10 14, 15 26, 23 31, 33 39; we further calculated total, free, bioavailable 25(OH)D. Conditional logistic regression models...
Abstract Succession of gut microbial community structure for newborns is highly influenced by early life factors. Many preterm infants cared in the NICU are exposed to parent–infant separation, stress, and pain from medical care procedures. The purpose study was investigate impact stress on trajectory structure. Stool samples very were collected weekly 6 weeks. exposure data daily V4 region 16S rRNA gene amplified PCR sequenced. Zero‐inflated beta regression model with random effects used...
Objective Women with a history of gestational diabetes mellitus (GDM) have an exceptionally high risk for type 2 (T2D). Yet, little is known about genetic determinants T2D in this population. We examined the association score (GRS) two independent populations women GDM and how might be modified by non-genetic T2D. Research design methods This cohort study included 2434 white from Nurses’ Health Study II (NHSII, n=1884) Danish National Birth Cohort (DNBC, n=550). A GRS was calculated using 59...
OBJECTIVE We prospectively evaluated plasma amino acids (AAs) in early pregnancy and midpregnancy their interplay with phospholipid fatty (FAs) association gestational diabetes mellitus (GDM) risk. RESEARCH DESIGN AND METHODS From a longitudinal cohort of 2,802 individuals, concentrations 24 AAs at 10–14 15–26 weeks (GW) were assessed among 107 GDM case subjects 214 non-GDM control subjects. estimated adjusted odds ratios (OR) 95% CI for the associations joint FAs risk, adjusting risk...
Whether and how socioeconomic status (SES) influences the associations between type 2 diabetes mellitus (T2DM) lactation remains unknown. We aimed to evaluate duration T2DM from a perspective of SES disparity. A total 263,859 parous women without at baseline (2004-2008) in China Kadoorie Biobank were included. Lactation was counted for first-child, per-child lifetime. The latent class analysis (LCA) education level, household income, occupation, residence conducted derive as low,...
OBJECTIVE To examine whether gestational diabetes mellitus (GDM), independent of subsequent diabetes, is an early risk factor for renal impairment long term after the index pregnancy. RESEARCH DESIGN AND METHODS In Diabetes & Women’s Health (DWH) study (2012–2016), we examined and joint associations GDM with long-term function among 607 women 619 without in Danish National Birth Cohort (DNBC) pregnancy (1996–2002). At median follow-up 13 years pregnancy, serum creatinine (mg/dL) urinary...
Abnormal blood pressure during pregnancy is associated with impaired fetal growth, predisposing the offspring to cardiometabolic abnormalities over life-course. Placental DNA methylation may be regulatory pathway through which maternal influences and adult health outcomes. Epigenome-wide association study of 301 participants placenta sample examined associations between millimetre mercury increases in systolic diastolic each trimester. Findings were further using gene expression, pathway,...
Abstract The development of next-generation sequencing (NGS) enabled a shift from array-based genotyping to directly genomic libraries for high-throughput genotyping. Even though whole-genome was initially too costly routine analysis in large populations such as breeding or genetic studies, continued advancements genome and bioinformatics have provided the opportunity capitalize on information. As new platforms can routinely provide high-quality data sufficient coverage genotype various...
Evidence has indicated that polyunsaturated fatty acids (PUFAs)-enriched diet could reduce inflammation because of thyroid autoimmunity in vivo, and therefore, enhance function. We investigated whether early pregnancy plasma phospholipid PUFAs benefit maternal function across pregnancy, which is critical to fetal brain development growth pregnancy. Within the National Institute Child Health Human Development Fetal Growth Studies-Singleton Cohort, we collected samples longitudinally from 214...
Background Platycodon grandiflorus belongs to the genus and has many pharmacological effects, such as expectorant, antitussive, anti-tumor properties. Among transcription factor families peculiar eukaryotes, basic leucine zipper (bZIP) family is one of most important, which exists widely in plants participates biological processes, plant growth, development, stress responses. However, genomic analysis bZIP gene related response genes not yet been reported P. . Methods (PgbZIP) were first...
Amino acids, fatty and acylcarnitine metabolites play a pivotal role in maternal fetal health, but profiles of these over pregnancy are not completely established. We described longitudinal trajectories targeted amino acylcarnitines pregnancy. quantified 102 combinations (37 37 28 acylcarnitines) plasma samples from pregnant women the Eunice Kennedy Shriver National Institute Child Health Human Development (NICHD) Fetal Growth Studies-Singletons cohort (n = 214 at 10-14 15-26 weeks, 107...
Trueperella pyogenes is an opportunistic pathogen that causes suppurative infections in animals including humans. Data on phenotypic and genotypic properties of T. isolated from ruminants, particularly goats sheep, are lacking. We characterized, by means, caprine ovine origin, established their phylogenetic relationship with isolates other ruminants. ( n = 50) diagnostic specimens bovine 25), 19), 6) origin were analyzed. Overall, variable biochemical activities observed among the isolates....
Artificially sweetened beverages (ASBs) are commonly consumed and recommended for individuals at high risk cardiometabolic diseases; however, the health effects of ASBs remain contradictory. Given that cross-sectional analyses subject to reverse causation, prospective studies with long-term follow-up needed evaluate associations between health, especially among high-risk individuals.