A5102020263- Gut microbiota and health
- Sexual Differentiation and Disorders
- Diet and metabolism studies
- Growth Hormone and Insulin-like Growth Factors
- Hypothalamic control of reproductive hormones
- Birth, Development, and Health
- Adipokines, Inflammation, and Metabolic Diseases
- Diabetes Management and Research
- Urological Disorders and Treatments
- Genomics and Rare Diseases
- Adipose Tissue and Metabolism
- Genetic and Clinical Aspects of Sex Determination and Chromosomal Abnormalities
- Clostridium difficile and Clostridium perfringens research
- Protist diversity and phylogeny
- Pancreatic function and diabetes
- Diabetes and associated disorders
- Urologic and reproductive health conditions
- Dietary Effects on Health
- Ubiquitin and proteasome pathways
- Genetics and Neurodevelopmental Disorders
- Pelvic floor disorders treatments
- Ovarian cancer diagnosis and treatment
- Obesity, Physical Activity, Diet
- Regulation of Appetite and Obesity
- Hormonal and reproductive studies
Fujian Medical University
2016-2025
Jiangnan University
2023-2024
Shandong First Medical University
2024
State Key Laboratory of Food Science and Technology
2023-2024
Institute of Genetics and Developmental Biology
2023
People's Liberation Army 401 Hospital
2020-2023
Dongbei University of Finance and Economics
2023
Ministry of Agriculture and Rural Affairs
2022
Jimei University
2022
Children's Hospital of Fudan University
2021
Abstract Gut dysbiosis has been linked to type 1 diabetes (T1D); however, microbial capacity in T1D remains unclear. Here, we integratively profiled gut functional and metabolic alterations children with new-onset independent cohorts investigated the underlying mechanisms. In T1D, microbiota was characterized by decreased butyrate production bile acid metabolism increased lipopolysaccharide biosynthesis at species, gene, metabolite levels. The combination of 18 bacterial species fecal...
OBJECTIVES: To determine the current prevalence and mean ages of onset pubertal characteristics in healthy urban Chinese girls. METHODS: A cross-sectional study sexual maturation girls was conducted 9 representative cities eastern, western, southern, northern parts central region China between 2003 2005. At examination, stages breast pubic hair development were rated on 3 through 19.83 years age, height weight also recorded. Data menses collected by status quo method. Probit analysis used to...
Abstract Background Accumulating evidence infer that gut microbiome-host relations are key mediators or modulators driving the observed sexual dimorphism in some disease onset and progression. To date, sex-differences of microbiota at different pubertal status have not been reported. Objective determine characteristics both genders status. Methods Gut was analyzed 89 Chinese participants aged 5–15 years. Participants were divided into pre-puberty puberty groups for male female. The...
Abstract Background The make-up of gut microbiota at different puberty stages has not been reported. This cross-sectional study analyzed the bio-diversity stages. Result subjects (aged 5–15 years) were divided into non-pubertal ( n = 42, male%: 66.7%) or pubertal groups 47, male%:44.68); in both groups, Firmicutes , Bacteroidetes and Proteobacteria dominant phylum. There was no difference alpha- beta-diversity among disparate Non-pubertal had members order Clostridiales, family...
Abstract Background The term “metabolically healthy obese (MHO)” denotes a hale and salutary status, yet this connotation has not been validated in children, may, fact, be misnomer. As pertains to obesity, the gut microbiota garnered attention as conceivably nosogenic or, on other hand, protective participator. Objective This study explored characteristics of fecal Chinese children adolescents disparate metabolic statuses, associations between their circulating proinflammatory factors, such...
Objective The intestinal flora of gut microbiota in obese Chinese children and adolescents with without insulin resistance (IR) was analyzed, as well associations between the two serum cytokines related to glucose metabolism, adropin angiopoietin-like 4 (ANGPTL4). Methods Clinical data, fecal bacterial composition, glucose-related hormones, adipokines (adropin ANGPTL4) were analyzed 65 exogenous obesity. composition determined by 16S rRNA-based metagenomics IR calculated using homeostasis...
Abstract Context The evidence of long-term polyethylene glycol recombinant human GH (PEG-rhGH) in pediatric deficiency (GHD) is limited. Objective This study aimed to examine the effectiveness and safety PEG-rhGH children with GHD real world, as well effects dose on patient outcomes. Design A prospective, observational, posttrial (NCT03290235). Setting, participants intervention Children were enrolled from 81 centers China 4 individual clinical trials received weekly 0.2 mg/kg/wk (high-dose)...
Abstract Background The real-world exposure levels of non-therapeutic antibiotics and neonicotinoids in type 1 diabetes (T1D) children their associations as environmental triggers through gut microbiota shifts remained unknown. We thus investigated the neonicotinoids’ with pediatric T1D. Methods Fifty-one newly onset T1D along 67 age-matched healthy controls were recruited. Urine concentrations 28 12 measured by mass spectrometry. Children grouped according to kinds antibiotics’ exposures,...
To investigate the characteristics of gut microbiota in children with disparate degrees adiposity, and analyze association between microbiota, glucose metabolism indicators, inflammatory factors.Clinical data were examined 89 Chinese children. Children a body fat percentage ≥ 30% diagnosed as obese, 35% males 40% females further defined severe obesity. The composition was determined by 16S rDNA-based metagenomics.The study population (9.75 ± 1.92-year-old) characterized normal weight (n =...
Abstract Context Age of pubertal onset has been decreasing in many countries but there have no data on development Chinese children over the last decade. Objective The primary objective study was to evaluate current status sexual maturation and adolescents. Secondary objectives were examine socioeconomic, lifestyle, auxological associations with onset. Methods In this national, cross-sectional, community-based health survey, a multistage, stratified cluster random sampling method used select...
Cholecystectomy (CCE) is a standard clinical treatment for conditions like gallstones and cholecystitis. However, its link to post-CCE syndrome, colorectal cancer, nonalcoholic fatty liver disease has raised concerns. Additionally, studies have demonstrated the disruptive effects of CCE on gut microbiota homeostasis bile acid (BA) metabolism. Considering role in regulating host metabolic immune pathways, use dietary probiotic intervention strategies maintain stable ecosystem after could...
Long-term fine particulate matter (PM2.5) exposure was associated with childhood obesity. However, the key PM2.5 components and whether effect may vary by obesity type, growth stage, sex, individual/family characteristics have yet been examined. In this study, we investigated 213,907 Chinese children adolescents aged 3-18 years in 2017-2019. Three-year average concentrations of five major were assigned to each participant's address. Multivariable mixed-effects model weighted quantile sum...
In boys during puberty who were undergoing recombinant human growth hormone (rhGH) treatment, we compared the therapeutic efficacy on growth, and any adverse reactions, of co-therapy with either letrozole or gonadotropin-releasing analog (GnRHa). Fifty-six pubertal deficiency (GHD) studied, they treated combination rhGH (letrozole group, n = 28) GnRHa (GnRHa for at least one year. Eighteen patients in group seventeen attained final adult height (FAH). The increase was significantly more than...
Abstract Background The increasing incidence of precocious puberty is a major health challenge for Chinese children, while related risk factors remain less well explored. Exposure to ambient fine particulate matter (PM 2.5 ) leading environmental hazard in China. Although certain components PM have been reported be endocrine disruptors sex hormones, population-based evidence still lacking on the association between exposure and Objective Based cross-sectional survey covering 30 cities 2017...
CCCTC‐binding factor (CTCF) is an important regulator for global genomic organization and gene expression. CTCF had been implicated in a novel disorder characterized by intellectual disability, feeding difficulty, developmental delay microcephaly. So far, four patients have reported with de novo mutations. We three additional Chinese variants . The new evidence helped to establish the clinical validity between emerging disorder. described consistent phenotypes shared all revealed features...
In adults, gut dysbiosis may contribute to the pathogenesis of gout. However, characteristics microbiota in children with hyperuricemia (HUA) absence clinical gout have not been explored.
Gonadotropin-releasing hormone analogues (GnRHa) and recombinant human growth (rhGH) have been widely used to treat idiopathic central precocious puberty (CPP) or early fast (EFP). However, large-scale studies evaluate the treatment effects on final adult height (FAH) are still lacking.
The relationship between the oral microbiota and type 1 diabetes (T1D) remains unclear. We aimed to evaluate variations in microbiome T1D identify potentially associated bacterial factors.We performed high-throughput sequencing of V3-V4 area 16S rRNA gene profile composition 47 healthy children (CON group), 46 with new-onset acute phase (NT1D 10 chronic receiving insulin treatment (CT1D group). Multivariate statistical analysis data was performed.Compared CON group, NT1D group characterized...
Background The 5α-reductase type 2 (5α-RD2) deficiency caused by mutations in the steroid ( SRD5A2 ) gene results variable degrees of undervirilisation patients with 46,XY disorders sex development. This study aims to profile regional distribution and phenotype–genotype characteristics a large Chinese 5α-RD2 cohort through multi-centre analysis. Methods 190 subjects diagnosed were consecutively enrolled from eight medical centres China. Their clinical manifestations genetic variants...
Abstract Background To evaluate the effectiveness of individualized-dose polyethylene glycol recombinant human growth hormone (PEG-rhGH) for short stature. Methods This real-world study enrolled children with stature in 19 hospitals throughout China. They were treated PEG-rhGH 6 months. The starting dosage ranged from 0.10 to 0.20 mg/kg/week. primary outcome was change height standard deviation score (ΔHt SDS). Results Five hundred and ten patients included grouped based on as A (0.10–0.14...