A5100333937- Sexual Differentiation and Disorders
- Growth Hormone and Insulin-like Growth Factors
- Pancreatic function and diabetes
- Diabetes and associated disorders
- Sulfur Compounds in Biology
- Hemodynamic Monitoring and Therapy
- Hormonal Regulation and Hypertension
- Genetic Syndromes and Imprinting
- Digestive system and related health
- Genetic and Clinical Aspects of Sex Determination and Chromosomal Abnormalities
- Nitric Oxide and Endothelin Effects
- Diabetes Management and Research
- Cancer, Hypoxia, and Metabolism
- RNA modifications and cancer
- Congenital Heart Disease Studies
- Adrenal Hormones and Disorders
- SARS-CoV-2 and COVID-19 Research
- Birth, Development, and Health
- Immune Cell Function and Interaction
- DNA Repair Mechanisms
- Eicosanoids and Hypertension Pharmacology
- Peroxisome Proliferator-Activated Receptors
- Adipose Tissue and Metabolism
- Pulmonary Hypertension Research and Treatments
- Cancer Genomics and Diagnostics
Children's Hospital of Capital Institute of Pediatrics
2014-2024
China Three Gorges University
2013-2024
Capital Institute of Pediatrics
2008-2023
Weatherford College
2023
University of Surrey
2022
Binghamton University
2022
Pain and Rehabilitation Medicine
2021
Crown Bioscience (China)
2021
Guangdong Academy of Medical Sciences
2014
Guangdong General Hospital
2014
Abstract Context The evidence of long-term polyethylene glycol recombinant human GH (PEG-rhGH) in pediatric deficiency (GHD) is limited. Objective This study aimed to examine the effectiveness and safety PEG-rhGH children with GHD real world, as well effects dose on patient outcomes. Design A prospective, observational, posttrial (NCT03290235). Setting, participants intervention Children were enrolled from 81 centers China 4 individual clinical trials received weekly 0.2 mg/kg/wk (high-dose)...
Long-term treatment with angiotensin-converting enzyme (ACE) inhibitors as well angiotensin II type 1 (AT(1)) receptor antagonists and statins reduces cardiovascular mortality in patients coronary artery disease chronic heart failure. Little is known about the acute effects of these compounds on vascular reactivity resistance vessels. Coronary arterioles were obtained from undergoing bypass operation (atherosclerosis group) or valve replacement (control group). Responses to...
The incidence of type 1 diabetes mellitus (T1DM) is increasing rapidly worldwide for children every age group.A retrospective analysis hospital registration data from five tertiary hospitals in Beijing, China, identified 485 patients (210 boys, 275 girls) younger than 15 years with newly diagnosed T1DM between 1995 and 2010.From to 2010, the <15 ranged 0.935-3.26 per 100,000 year. During this period, average age-standardized rate was 1.7 year, annual increase 4.36%. highest increases...
China has a low incidence of type 1 diabetes mellitus (T1DM); however, based on the large population, absolute numbers are high. Our aim was to assess childhood T1DM in Beijing during 2011-2020, predicted for 2025-2035, and determine diabetic ketosis or ketoacidosis (DK/DKA) this population.Data patients aged less than 15 years age with newly diagnosed between January 1, 2011 December 31, 2020 obtained from five tertiary hospitals retrospectively analyzed.In all, 636 children were 2011-2020....
To investigate appropriate therapeutic strategies for graft-vs-host disease (GVHD) following liver transplantation.Four patients who developed GVHD after transplantation in West China Hospital were included this study. Therapeutic with augmentation or withdrawal of immunosuppressants combined supportive therapy investigated these patients. In addition, a literature review was performed.Although transient response to initial treatment detected, all four died complications from GVHD: one...
Pituitary stalk interruption syndrome (PSIS) is characterized by the association of an absent or thin pituitary stalk, hypoplastic anterior lobe and ectopic posterior (EPP) lobe. The causes this anatomical defect include both genetic environmental factors. Molecular defects have been indentified in a small number patients with PSIS. A 4-year-old boy presented hypoglycemia hyponatremia associated growth hormone, thyroid stimulating adrenocorticotropic hormone deficiencies. patient had right...
Objective 11β-Hydroxylase deficiency (11β-OHD) caused by mutations in the CYP11B1 gene is second most common form of congenital adrenal hyperplasia. Both point and genomic rearrangements are important causes 11β-OHD. However, high degree sequence identity between its homologous CYP11B2 , presents unique challenges for molecular diagnosis suspected The aim this study was to detect mutation, indel, small deletion chimeric / a one-tube test, improving genetic Methods Optimized custom-designed...
Heart rate variability (HRV) was used in the present study to evaluate a target-controlled approach compared with constant-rate infusion for remifentanil anesthesia during off-pump coronary artery bypass grafting (OP-CABG) surgery. A total of 65 patients American Society Anesthesiologists (ASA) physical status II or III, who were aged 60-85 years and scheduled OP-CABG, selected study. All administered an intramuscular premedication 10 mg morphine 0.3 scopolamine. In group I, infused using at...
We aimed to describe the safety and efficacy of insulin glargine in Chinese paediatric patients with type 1 diabetes mellitus (T1DM). Neutral protamine Hagedorn (NPH) was reference therapy. This open-label, randomised, Phase III study conducted at 10 sites China. Children aged ≥6 <18 years T1DM were randomised (2:1) or NPH asbasal insulinfor a 24-week treatment period. For all patients, aspart given as bolus insulin. The primary endpoint absolute change glycated haemoglobin(HbA1c) from...
Analysis of SARS-CoV-2 IgG antibody and neutralizing levels following infection in children aged 3-11 years, comparing those who had received the inactivated vaccine to were unvaccinated prior infection, provides evidence for public health centers formulating vaccination strategies control policies.A study was conducted on visited Children's Hospital, Capital Institute Pediatrics from January 10, 2023 March 31, (Beijing, China). Participants or their guardians completed a survey...
Disruption of lipid metabolism is largely linked to metabolic disorders, such as hypercholesterolemia (HCL) and liver steatosis. While cholesterol re-programmers can serve targets for relevant interventions. Here we explored the dietary conjugated linoleic acids (CLA)-induced HCL in mice molecular regulation behind it.A high dose CLA supplementation diet was used induce found cause a hyper-activated biosynthesis programme liver, leading dysregulation. The effects small-molecule drug...
Alstrom syndrome (ALMS) is a rare genetic disorder. ALMS characterized by progressive bilateral sensorineural hearing impairment, cone-rod dystrophy, infantile-onset cardiomyopathy, hypertriglyceridemia, accelerated non-alcoholic fatty liver disease, renal dysfunction and insulin-resistant diabetes mellitus (DM). DM typically develop in childhood or adolescence. Dilated cardiomyopathy may arise infancy. Clinical symptoms appear with great variability severity. Several cases have been...
To evaluate the clinical features and etiology of precocious puberty (PP) in Chinese boys.In this study, data from boys who were referred for evaluation PP 2015 to 2020 at a tertiary hospital Northern China retrospectively analyzed.Eighty-two diagnosed with 2020. Sixty-two patients (75.6%) central (CPP), twenty (24.4%) peripheral (PPP). In CPP group, forty-nine cases classified as idiopathic CPP, thirteen had pathogenic CPP. The top three causes PPP congenital adrenal hyperplasia, germ cell...
The use of inhibin B (INHB), anti-Müllerian hormone (AMH) and insulin-like growth factor-1 (IGF-1) in differentiating central precocious puberty (CPP) from non-CPP was evaluated.In total, 115 Chinese girls were recruited (CPP: 44, non-CPP: 71). diagnostic performance INHB, AMH IGF-1 CPP analyzed using receiver operating characteristic (ROC) curves.INHB levels higher the group than (55.56 ± 22.42 vs. 32.97 15.59 pg/mL; p<0.001). similar groups (6.63 3.74 5.70 3.15 p=0.158), much (290.75 79.78...
To explore the clinical characteristics and genetic basis for three children with Congenital chlorine diarrhea (CCD).Three CCD who attended Affiliated Children's Hospital of Capital Pediatric Institute from June 2014 to August 2020 were selected as research subjects. Peripheral blood samples their parents collected testing. And results verified by Sanger sequencing.The manifestations have included recurrent diarrhea, various degrees hypochloremia, hypokalemia refractory metabolic alkalosis....
Abstract Background Isodicentric Y chromosome (idic(Y)) is the most commonly reported aberration of human chromosome, which an important cause abnormal sexual development. The breakpoints isodicentric mostly occurred in Yq11.2 and Yp11.3, however, Yq12 are relatively rare. Case presentation We described a 10-year-old boy presenting hypospadias, micropenis short stature, as well unilateral cryptorchidism without normal testicular seminiferous tubules structure by biopsy. Whole exome...
rogressive pseudorheumatoid dysplasia (PPRD) is a rare autosomal-recessive, noninflammatory arthropathy.Several cases have been reported worldwide; however, diagnosis remains challenging.Three unrelated children with PPRD were retrospectively studied.All three patients in this study initially misdiagnosed.The misdiagnoses included juvenile rheumatoid arthritis, myodystrophy and idiopathic short stature.The time from the onset of symptoms to definitive was 3 8 years.Clinical signs...
Hemophagocytic lymphohistiocytosis (HLH) is an aggressive and life-threatening syndrome of excessive immune activation. Mesenchymal stem cells (MSCs) generate immunosuppressive microenvironment by secreting cytokines have been used to treat autoimmune diseases. We report the first case refractory secondary HLH treated with umbilical cord MSCs. A 52-year-old Chinese female patient a history type 2 diabetes was diagnosed based upon HLH-2004 protocol infusion third-party MSCs (1.4 × 10 6...
Objective To analyze the clinical characteristics and mutation of SLC26A3 gene a patient with congenital chloride diarrhea in order to deepen understanding disease. Methods The data who was admitted Affiliated Hospital Capital Pediatric Institute June 2014 were collected. Venous blood proband his parents (2 mL for each) had been extracted genomic DNA isolation.The 21 exons amplified polymerase chain reaction screened mutations by sequencing. Results The main cli-nical features...