A5056683844- Growth Hormone and Insulin-like Growth Factors
- Acupuncture Treatment Research Studies
- Diabetes, Cardiovascular Risks, and Lipoproteins
- Birth, Development, and Health
- Obesity, Physical Activity, Diet
- Genomic variations and chromosomal abnormalities
- Menstrual Health and Disorders
- Sexual Differentiation and Disorders
- Hypothalamic control of reproductive hormones
- Metabolism and Genetic Disorders
- Genetics and Neurodevelopmental Disorders
- Congenital heart defects research
- Diabetes Management and Research
- Psychosocial Factors Impacting Youth
- Genetics and Physical Performance
- Diet and metabolism studies
- Childhood Cancer Survivors' Quality of Life
- Alcohol Consumption and Health Effects
- Sarcoma Diagnosis and Treatment
- Nutrition, Health and Food Behavior
- Cancer-related molecular mechanisms research
- Gestational Diabetes Research and Management
- Cardiovascular Disease and Adiposity
- Artificial Intelligence in Healthcare
- Adipokines, Inflammation, and Metabolic Diseases
Capital Medical University
2023-2025
Peking University
2017-2025
Beijing Jishuitan Hospital
2017-2025
Children's Hospital of Capital Institute of Pediatrics
2007
Abstract Context The evidence of long-term polyethylene glycol recombinant human GH (PEG-rhGH) in pediatric deficiency (GHD) is limited. Objective This study aimed to examine the effectiveness and safety PEG-rhGH children with GHD real world, as well effects dose on patient outcomes. Design A prospective, observational, posttrial (NCT03290235). Setting, participants intervention Children were enrolled from 81 centers China 4 individual clinical trials received weekly 0.2 mg/kg/wk (high-dose)...
Objective To investigate the pubertal development in obese school-age children and explore associated factors. Method A total of 217 school-aged children, aged 6-12 years, visiting clinic at Beijing Jishuitan Hospital, Capital Medical University, were enrolled a study to complete series examinations. These assessments included body composition analysis, blood glucose levels, fasting insulin evaluations secondary sexual characteristic development. Statistical analysis was conducted using...
Objective: The objective of this study was to investigate the pubertal development in school-age children with obesity and explore body composition lifestyle behaviors influencing its onset. Method: We enrolled 217 children, aged 6–12 years, who visited Pediatrics Department at Beijing Jishuitan Hospital, Capital Medical University. All participants underwent a series examinations. These assessments included analysis, measurement blood glucose fasting insulin levels, evaluation secondary...
Objective The aim of this study was to explore the symptoms, treatment, and pathogenesis ovarian juvenile granulosa cell tumors with Ollier’s disease in children. Methods From October 2019 2020, clinical data were retrospectively analyzed for one case disease. Whole-exome sequencing Sanger used detect gene mutation tumor chondroma tissue. NADP-dependent isocitrate dehydrogenase-1 (IDH1) S6 ribosomal protein expression levels cells transfected wild-type or mutant plasmid by Western blot....
Context Long-acting recombinant human growth hormone (rhGH) has transformed deficiency (GHD) treatment. However, the possibility and rationality for flexible time regimen are pending. Objective We studied efficacy of biweekly versus weekly PEGylated rhGH (PEG-rhGH) therapy in GHD children. Design, Setting, Patients This multicenter, phase IV trial with a non-inferiority threshold ≥20% enrolled 585 Tanner stage I Intervention Subjects randomly received 0.20 mg/kg once-weekly or PEG-rhGH, 0.25...
Abstract Objective The aim of this study was to investigate when the association between childhood obesity and adult cardiometabolic disorders starts be operative. Methods cohort included 811 participants who had data on blood pressure, lipid profile, fasting glucose, insulin, or alanine aminotransferase in adulthood at least one measurement BMI childhood. Results Childhood z score significantly associated with increased risks ≥1 disorders, ≥2 elevated pressure for age groups 6 9 years, 10...
18p deletion syndrome is a rare chromosomal disease caused by of the short arm chromosome 18. By using cytogenetic and SNP array analysis, we identified girl with exhibiting craniofacial anomalies, intellectual disability, stature. G-banding analysis metaphase cells revealed an abnormal karyotype 46,XX,del(18)(p10). Further, detected 15.3-Mb at 18p11.21p11.32 (chr18:12842-15375878) including 61 OMIM genes. Genotype-phenotype correlation showed that clinical manifestations patient were...
To explore the effect of transcutaneous electrical acupoint stimulation (TEAS) combined with auricular acupressure on serum sexual hormone level, and ovarian, follicular uterine development in girls precocious puberty.Sixty puberty were randomly divided into a control group (30 cases, 2 cases dropped off) treatment 3 off). In both group, healthy life-style intervention was provided for 12 weeks. Besides, TEAS delivered 20 minutes each time, twice week; bilateral combined. The duration levels...
Abstract Background To investigate the differential diagnosis of girls aged 6 to 8 years with idiopathic premature thelarche (IPT) and central precocious puberty (CPP) during COVID-19 pandemic. We explored predicted adult height (PAH) discrepancy guide appropriate treatment. Methods From January 2020 December 2021, Chinese were recruited. They divided into IPT CPP groups. Clinical characteristics, including height, weight, body mass index (BMI), basal luteinizing hormone (LH), oestradiol,...
International studies have found that the blood triglycerides to highdensity lipoproteins (TG/HDL-C) ratio predicted insulin resistance in children with overweight and obesity. However, there is a lack of such reports on from China.
Objective The aim of the study was to investigate relationship between SLC37A4 gene mutation and clinical phenotype in a patient with glycogen storage disease-type I. Methods data one I accumulation syndrome results testing were analyzed. DNA from peripheral blood used analyze mutations his parents. Results carried compound heterozygous SLC37A4, mother for c.572C > T (p.P191L) mutation, father c.359C (p.P120L) mutation. Conclusion had two mutations: (p.P120L), which is closely related I,...
Due to the increasing insulin resistance (IR) in childhood, rates of diabetes and cardiovascular disease may rise future seriously threaten healthy development children. Finding an easy way predict IR children can help pediatricians identify these time intervene appropriately, which is particularly important for practitioners primary health care.Seventeen features from 503 6-12 years old were collected. We defined by HOMA-IR greater than 3.0, thus classifying with those without IR. Data...
Objective: To explore the interrelationship among three simplified hand and wrist bone age assessment methods to establish corresponding ages for each substage in male children. Methods: This retrospective case series study included 169 left X-rays from 152 children who underwent assessments at Pediatric Orthopedics Pediatrics Departments,Beijing Jishuitan Hospital,Capital Medical University January 2019 December 2023. The time of X-ray was (13.7±2.0) years (range:9.1 17.9 years). Reasons...
Objective To investigate the bone mineral density (BMD) and body composition of school-age children with different obesity levels explore influencing factors in children. Method A total 217 school-aged (ages 6-12) visiting clinic at Beijing Jishuitan Hospital, Capital Medical University, were enrolled. They underwent a series examinations, including assessments composition, BMD distal ulna radius, abdominal ultrasound, blood fasting insulin, calcium, 25-OH-D, etc. Statistical analysis was...
To study primarily on the effect of acupuncture breast Tanner stage, serum sex hormone level, and TCM symptom scores in girls with peripheral precocious puberty (PPP).19 eligible patients diagnosed PPP received intervention for 12 weeks, twice a week 24 sessions treatment all, then follow-up weeks. The primary outcome was change luteinizing (LH) follicle-stimulating (FSH) stage at 12-week follow-up. Serum estradiol (E2) level were also assessed.Nineteen treated acupuncture. After...
Abstract Background Syndromic short stature is a genetic and phenotypic heterogeneous disorder with multiple causes. This study aims to identify causes in patients syndromic of unknown cause evaluate the efficacy growth hormone response. Methods Trio-whole-exome sequencing was applied pathogenic gene mutations seven patents stature, malformations, and/or intellectual disability. Whole-genome low-coverage also performed copy number variants three concurrent Recombinant human administered...
To analyze the clinical phenotypes of a pedigree affected with periodic paralysis and explore its molecular basis.Clinical data peripheral blood samples were collected. The proband his father both complained dysmorphic features. exome was screened using Roche NimbleGen probes, results confirmed by Sanger sequencing. Suspected mutations subjected to bioinformatic gene-disease correlation analysis.A c.653G>A (p.R218Q) mutation KCNJ2 gene detected in father. Bioinformatics analysis suggested it...
Peripheral precocious puberty(PPP),also known as puberty independent from hypothalamic-pituitary axis activation,is stimulated by hormones other sources, with only partial sexual characteristics development but without mature function. The secondary occurs before 7.5 years of age in girls and 9 boys. Clinical manifestations are diverse, PPP has varied etiology including congenital adrenal hyperplasia, McCune-Albright syndrome, ovarian cyst, tumor, testicular human chorionic gonadotropin...
To observe the efficacy and safety of acupuncture combined with auricular point sticking for girls aged 3-8 years incomplete precocious puberty (IPP).Sixty IPP were randomly divided into an observation group (30 cases, 2 cases dropped off) a control eliminated). The in treated healthy diet proper exercise 12 weeks. On basis treatment group, sticking. was applied at Sanyinjiao (SP 6), Guanyuan (CV 4), Guilai (ST 29), etc., needles retained 20 min, given twice week (once every 3 days)....
Objective To investigate the clinical features of non-syndromic mitochondrial disease in children which were identified by respiratory chain enzyme complex activity assay. Methods From March 2010 to April 2011, seven who diagnosed as included into this study. The complexes (Ⅰ-Ⅳ) and ATP synthase (complex Ⅴ) peripheral blood leukocytes 7 determined. All whose routine screening genes negative. Children's data retrospectively analyzed. Results ①There intelligence backwards after...
Objective To investigate insulin resistance and first-phase secretion among the obese children with normal glucose tolerance, impaired tolerance (IGT) type 2 diabetes mellitus(T2DM) to further explore their effects on T2DM. Methods Both physical examination oral test (OGTT) were performed determine levels a total of 87 subjects.They divided into group, IGT group T2DM according levels.Insulin resis-tance represented by sensitivity index (IAI) △I30/△G30=(I30 min-I0 min)/(G30 min-G0...
To observe the effect of electroacupuncture on sexual development and ovarian estrogen receptor β(ER-β) expression in female adolescent obese rats induced by high-fat diet, so as to explore its underlying mechanisms improving obesity.Female SD (age 21 days) were randomly divided into control, model acupuncture groups, with 6 each group. The was established feeding diet for weeks. Rats group received electroacupuncture(2 Hz, 0.5-1.2 mA)stimulation at bilateral "Sanyinjiao"(SP6),...