A5004695739- Hair Growth and Disorders
- Traumatic Brain Injury and Neurovascular Disturbances
- Skin and Cellular Biology Research
- Glaucoma and retinal disorders
- Rabbits: Nutrition, Reproduction, Health
- Ubiquitin and proteasome pathways
- Wound Healing and Treatments
- Retinopathy of Prematurity Studies
- Retinal Development and Disorders
- Neuroscience and Neuropharmacology Research
- Animal Nutrition and Physiology
- Mitochondrial Function and Pathology
- Retinal Diseases and Treatments
- Nitric Oxide and Endothelin Effects
- Cancer-related Molecular Pathways
- High Altitude and Hypoxia
- Anesthesia and Neurotoxicity Research
- Cardiac Ischemia and Reperfusion
- Eicosanoids and Hypertension Pharmacology
- Prenatal Screening and Diagnostics
- Hedgehog Signaling Pathway Studies
- Genomic variations and chromosomal abnormalities
- Esophageal Cancer Research and Treatment
- Circadian rhythm and melatonin
- RNA modifications and cancer
Northwest University
2022-2025
Northwest University First Hospital
2025
Anhui Medical University
2025
Zaozhuang University
2025
Shenyang Pharmaceutical University
2023-2024
Minzu University of China
2024
Ministry of Education of the People's Republic of China
2022-2024
Shandong Agricultural University
2013-2021
Capital Institute of Pediatrics
2012-2021
Shandong Academy of Agricultural Sciences
2020
Abstract Peroxisome proliferator-activated receptor gamma coactivator-1 (PGC-1) family (PGC-1s), consisting of three members encompassing PGC-1α, PGC-1β, and PGC-1-related coactivator (PRC), was discovered more than a quarter-century ago. PGC-1s are essential coordinators many vital cellular events, including mitochondrial functions, oxidative stress, endoplasmic reticulum homeostasis, inflammation. Accumulating evidence has shown that implicated in diseases, such as cancers, cardiac...
To determine whether the duration of ischemic tolerance in retina could be extended by repetitive presentations preconditioning stimulus and to begin elucidate mechanistic underpinnings resultant novel phenotype.Adult male Swiss-Webster ND4 mice were repeatedly preconditioned with systemic hypoxia (RHP) over 12 days; 4 weeks later, subjected 30 minutes unilateral retinal ischemia. Protection was quantified morphologically functionally 1 week after ischemia histologic analyses scotopic...
The Wlds mutation affords protection of retinal ganglion cell (RGC) axons in ischemia and inducible hereditary preclinical models glaucoma. We undertook the present study to determine whether Nmnat1 portion chimeric protein provides axonal somatic RGCs glaucoma, particularly when localized nonnuclear regions cell.The survival integrity RGC soma from transgenic mice with confirmed cytoplasmic overexpression retina optic nerve (cytNmnat1-Tg mice) were examined postlaminar 4 days following...
The objective of this experiment was to determine whether changing the dietary neutral detergent fiber (NDF)/starch ratio affected caecal microbiota when 4 different diets (diet A: 2.3 NDF/starch, diet B: 1.9, C: 1.4, D: 1.0) were formulated. A total 200 weaned rabbits (35 days old, 50 per group) used for experiment, which started after an adaptation period 7 (i.e., day 42). Caecal contents obtained from fed NDF/starch at 52, 62, 72, and 82 life. bacterial community structure characterized...
The structures and magnetic properties of nanocompsite Fe-Pt-B ternary alloys were investigated in a wide composition range. A single amorphous phase was formed the melt-spun alloy ribbons with range 0-15 at. % Pt 20-30 B, while ranges fcc-FePt + amorphous, Fe2B L10-FePt Fe2B/FeB phases out amorphous. With more than 5 Pt, crystallized structure consisting nanoscale obtained after annealing except for 0-10 15-25 B. annealed no less 10 exhibit good hard properties. Increasing B propitious to...
Outer bulge (OB) hair follicle stem cells (HFSCs) play a crucial role in maintaining structural stability and regulating the cycle. Previous studies demonstrated that keratin 24 (Krt24) exhibits spatiotemporally restricted expression OB HFSCs. Here, we report generation of Krt24-CreERT2 mouse line. When crossed with Rosa26LSL-tdTomato or Rosa26LSL-DTR reporter lines, offspring exhibited specific labeling (Krt24-CreERT2;Rosa26LSL-tdTomato) ablation (Krt24-CreERT2;Rosa26LSL-DTR) Krt24+ cells....
Abstract Wnt signaling plays an important role in the growth and development of hair follicles (HFs). Among molecules, Wnt10b was shown to promote differentiation primary skin epithelial cells toward shaft inner root sheath HF mice vitro. Whisker HFs were isolated from Rex rabbits cultured vitro measure growth. Meanwhile, dermal papilla (DPCs) Treatment with AdWnt10b or Wnt/β-Catenin Pathway inhibitor, XAV939, assessed DPCs proliferation by CCK-8 assay. And cell cycle also analyzed flow...
purpose. To determine the relative contributions of inner and outer retinal photoreception to pupillary light response. methods. Wild-type, degenerate (rd/rd), melanopsin mutant (opn4 −/−) mice were tested for responsiveness by video pupillometry before, during, after exposure supersaturating intensities. Similar lighting protocols used probe responses intrinsically photosensitive ganglion cells (ipRGCs) recorded with multielectrode arrays ex vivo. results. Both photoreceptors (rods cones)...
The 16p11.2 deletion is a recurrent genomic event and significant risk factor for autism spectrum disorders (ASD). This disorder also exhibits extensive phenotypic variability diverse clinical phenotypes. full extent of heterogeneity associated with the factors that modify phenotypes are currently unknown. Multiplex families offer unique opportunities exploring degree implicating modifiers. Here we reported characteristics three carriers in Chinese family. father carries de novo deletion, it...
Like all cells, neurons adapt to stress by transient alterations in phenotype, an epigenetic response that forms the basis for preconditioning against acute ischemic injury central nervous system. We recently showed a modified repetitive hypoxic (RHP) regimen significantly extends window of tolerance retinal from days months. The present study was undertaken determine if this uniquely protracted neuroprotective phenotype would also confer resistance glaucomatous neurodegeneration. Retinal...
Sepsis causes multiple organ injuries, among which the heart is one most severely damaged organ. Melatonin (MEL) alleviates septic myocardial injury, although a systematic and comprehensive approach still lacking to understand precise protective machinery of MEL. This study aimed examine underlying mechanisms MEL on improvement injury at level. integrated three analytic modalities including database investigations, RNA-seq analysis, weighted gene co-expression network analysis (WCGNA), in...
The latest research shows that ferns and lycophytes have distinct evolutionary lineages. codon usage patterns of not yet been documented. To investigate the gene expression profiles across various plant lineages with respect to usage, analyze disparities determinants evolution in primitive species, identify appropriate exogenous platforms, whole-genome sequences four species were retrieved from NCBI database. findings indicated
Objective: “Ischemic tolerance” can be induced in the retina by “preconditioning” with brief periods of non-injurious retinal ischemia or systemic hypoxia. The present study was undertaken to assess whether tolerance pharmacologically deferroxamine (DFX), an iron chelator, which promotes expression transcription factor, hypoxia-inducible factor 1-alpha (HIF-1α), and identify potential HIF-1α -induced effectors this endogenous protective response. Methods: ND4 Swiss-Webster mice were...
Abstract Background Hair follicles are an appendage of the vertebrate epithelium in skin that arise from embryonic ectoderm and regenerate cyclically during adulthood. Dermal papilla cells (DPCs) key dermal component hair follicle directly regulate development, growth regeneration. According to recent studies, miRNAs play important role regulating morphogenesis proliferation, differentiation apoptosis stem cells. Results The miRNA expression profile DPCs Rex rabbits with different densities...
Abstract This study investigated the influence of dietary fiber levels on growth performance, digestion, metabolism, and cecal microbial community rabbits with different diets at age. The natural detergent ( NDF ) were formulated accordingly: 400(A), 350(B), 300(C), 250(D) g/kg original matter basis, respectively; ages 52, 62, 72 days. With increasing, average daily feed intake ADFI conversion rate FCR increased, whereas gain ADG mortality decreased p < 0.05). stomach relative weight,...
This study was conducted to evaluate the effect of pyridoxine on development hair follicles in Rex rabbits and underlying molecular mechanism. Two hundred 3-month-old were randomly divided into 5 groups fed diets supplemented with 0, 5, 10, 20, or 40 mg/kg pyridoxine. The follicle density dorsal skin gene protein expression levels components phosphoinositide 3-kinase (PI3K)/protein kinase B (PKB Akt), Wnt, Notch bone morphogenetic (BMP) signalling pathways measured. In addition, free...