A5100453056- Schizophrenia research and treatment
- Attention Deficit Hyperactivity Disorder
- Genetics and Neurodevelopmental Disorders
- Genomic variations and chromosomal abnormalities
- Epilepsy research and treatment
- Bipolar Disorder and Treatment
- Cancer, Stress, Anesthesia, and Immune Response
- Dementia and Cognitive Impairment Research
- Neurogenetic and Muscular Disorders Research
- Cholesterol and Lipid Metabolism
- Genomics and Rare Diseases
- Healthcare Decision-Making and Restraints
- Liver Disease Diagnosis and Treatment
- Chemotherapy-induced organ toxicity mitigation
- Genetic Associations and Epidemiology
- Acute Kidney Injury Research
- Amyotrophic Lateral Sclerosis Research
- Digestive system and related health
- Identity, Memory, and Therapy
- Lipid metabolism and disorders
- Psychopathy, Forensic Psychiatry, Sexual Offending
- Breastfeeding Practices and Influences
- Aging and Gerontology Research
- Psychosomatic Disorders and Their Treatments
- Congenital heart defects research
Wenzhou Medical University
2025
Dongyang People's Hospital
2025
Shandong Provincial Hospital
2025
Shandong Xiehe University
2024
Capital Institute of Pediatrics
2017-2023
Peking Union Medical College Hospital
2014-2023
Chinese Academy of Medical Sciences & Peking Union Medical College
2014-2023
University of Maryland, Baltimore
2011-2022
The Affiliated Yongchuan Hospital of Chongqing Medical University
2021
Chongqing Medical University
2021
Venous thromboembolism (VTE), including pulmonary embolism (PE) and deep vein thrombosis (DVT), is the third most common cardiovascular disease. A low amount of mitochondrial DNA copy number (mtDNA-CN) reflects dysfunctions has been associations with arterial diseases. However, role mtDNA-CN in venous disease was unclear. We aimed to implement a 2-sample Mendelian randomization analysis approximate causal nature these relationships. Genetic instruments for VTE, PE, DVT were derived from...
Article AbstractBackground: Currently available antipsychotic medications offer only modest, if any, effects on cognitive performance in people with schizophrenia. Treatments that would improve these impairments could lead to better functional outcomes. Atomoxetine is a nonstimulant, selective norepinephrine reuptake inhibitor approved for the treatment of attention-deficit/hyperactivity disorder. In animals, it has been shown increase extracellular levels acetylcholine and dopamine cortical...
Objective:Describe treatment patterns, resource use, and predictors of methylphenidate (MPH) switch among children (6–12 years), adolescents (13–17 adults (≥18 years) with attention-deficit/hyperactivity disorder (ADHD).Methods:This retrospective U.S. managed care database study used medical, pharmacy, enrollment data to examine patterns patients ≥1 ADHD diagnosis code (ICD-9 314.00-314.9), MPH pharmacy claims during 01/01/2004–09/30/2006, no in prior 6 months. Patients were followed for 1...
Abstract Recurrent proximal 16p11.2 deletion (16p11.2del) is a risk factor for diverse neurodevelopmental disorders with incomplete penetrance and variable expressivity. Although investigation human induced pluripotent stem cell models has confirmed disruption of neuronal development in 16p11.2del cells, which genes are responsible abnormal cellular phenotypes what determines the abnormalities unknown. We performed haplotype phasing region cohort generated cells two families distinct...
ATP-binding cassette transporter G1 (ABCG1) is a transmembrane cholesterol involved in macrophage sterol homeostasis, reverse transport (RCT), and atherosclerosis. The role of ABCG1 atherosclerosis remains controversial, especially animal models. Our previous study showed that single nucleotide polymorphism rs57137919 (-367G>A) the promoter region was associated with reduced risk for atherosclerotic coronary artery disease (CAD). This designed to provide functional evidence rs57137919G>A...
Amyotrophic lateral sclerosis (ALS) is a devastating neurodegenerative disorder characterized by the death of motor neurons. Recently, mutations in CHCHD10 have been reported to cause ALS Western populations. In present study, direct DNA sequencing has performed on cohort 294 patients Chinese Han origin. No were identified cases ancestry. We propose might not be frequent causal gene among with ALS.
Abstract Objective We determined the yield, genetic spectrum, and actual origin of de novo mutations (DNMs) for infantile spasms (ISs) in a Chinese cohort. The efficacy levetiracetam (LEV) STXBP1 ‐related ISs was explored also. Methods Targeted sequencing 153 epilepsy‐related candidate genes applied to 289 patients with undiagnosed ISs. Trio‐based amplicon deep used all DNMs distinguish somatic/mosaic from germline ones. Results Total 26 were identified recruited Among them, 24 interpreted...
Abstract Background Neurodevelopmental disorders (NDDs) are a group of with high genetic and phenotypic heterogeneities. The 16p11.2 microdeletion has been implicated as an important risk factor for NDDs. Methods Multiple tests were used to detect the from 918 Chinese children Targeted sequencing genes in interval was performed all carriers microdeletion, whole‐genome expression profiling analysis patient normal their intra‐family. Results Three patients carrying screened out, indicating...
Background: Cardiovascular Risk Factors, Ageing and Dementia (CAIDE) risk score serves as a credible predictor of an individual’s dementia. However, studies on the link CAIDE to Alzheimer’s disease (AD) pathology are scarce. Objective: To explore links cerebrospinal fluid (CSF) biomarkers AD well cognitive performance. Methods: In Chinese Biomarker LifestylE (CABLE) study, we recruited 600 cognitively normal participants. Correlations between CSF performance were probed through multiple...
Introduction: Patients who come to the emergency department because of acute psychiatric symptoms are often not admitted correct timely. The purpose this study is identify clinical characteristics patients with in order achieve early and triage room. Methodology: We conducted a cross-analysis inpatients first came then neurology or psychiatry between years 2012 2018. Among them, 70 were rediagnosed retransferred, 38 32 psychiatry. characteristics, laboratory examination, Neuropsychiatric...
Abstract Background Pediatric myelodysplastic syndromes (MDS) display clonal genomic instability that can lead to acquisition of other hematological disorders, usually by loss heterozygosity. Immunodeficiency caused uniparental disomy (UPD) has not previously been reported. Methods We investigated a 13‐year‐old boy who suffered from recurrent infections and pancytopenia for 1 year. Both the comet assay chromosome breakage analysis were normal, but bone marrow showed evidence dysplasia...