A5083363534- Genetics and Neurodevelopmental Disorders
- Epilepsy research and treatment
- Neuroscience and Neuropharmacology Research
- Genomics and Rare Diseases
- MicroRNA in disease regulation
- Metabolism and Genetic Disorders
- Mitochondrial Function and Pathology
- RNA regulation and disease
- Ion channel regulation and function
- Barrier Structure and Function Studies
- Genomic variations and chromosomal abnormalities
- Neurological Disease Mechanisms and Treatments
- RNA modifications and cancer
- Autoimmune Neurological Disorders and Treatments
- Cellular transport and secretion
- Cancer-related molecular mechanisms research
- Bacterial Infections and Vaccines
- Neonatal and fetal brain pathology
- Advanced biosensing and bioanalysis techniques
- Diet and metabolism studies
- RNA and protein synthesis mechanisms
- Pharmacological Effects and Toxicity Studies
- S100 Proteins and Annexins
- Congenital heart defects research
- RNA Interference and Gene Delivery
Central South University
2016-2025
Xiangya Hospital Central South University
2016-2025
Hunan Children's Hospital
2015-2024
University of Arizona
2019-2024
Liaocheng University
2018-2020
Liaoning Cancer Hospital & Institute
2014
Beijing Normal University
2010-2013
Kunming University of Science and Technology
2010
University of Tennessee Health Science Center
2004-2005
Summary Purpose: Increasing evidence indicates that neuroinflammation plays a critical role in the pathogenesis of mesial temporal lobe epilepsy (MTLE). The aim this study was to investigate dynamic expression interleukin (IL)–1β as proinflammatory cytokine and microRNA (miR)‐146a posttranscriptional inflammation‐associated (miRNA) hippocampi an immature rat model children with MTLE. Methods: To IL‐1β miR‐146a, we performed reverse transcription polymerase chain reaction, Western blot,...
Th cells that produce IL-17 (Th17 cells) are a distinct subset of implicated in several autoimmune diseases. Although CD28-B7 interaction has been shown to be involved Th17 differentiation vitro, the role CTLA-4 controlling development is completely unknown. We report this paper blocking CTLA-4-B7 potentiates cell vitro and vivo. Furthermore, vivo confers susceptibility experimental myocarditis CD28(-/-) mice or increases severity wild-type mice. The enhanced disease mediated by heightened...
West syndrome (WS) is a classic form of early infantile epileptic encephalopathy (EIEE) characterized by tonic spasms with clustering, arrest psychomotor development, and hypsarrhythmia on electroencephalography. Genetic defects play critical role in the pathology WS, 54 EIEE genes have been identified till date. This study was designed to uncover new candidate for syndrome.In this study, we recruited 56 Chinese families WS unknown etiology. Whole exome sequencing (WES) performed identify...
Autism spectrum disorder (ASD) is frequently comorbid with other neurological disorders such as intellectual disability (ID) or global development delay (GDD) and epilepsy. The pathogenesis of ASD complex. So far, studies have identified more than 1000 risk genes. Most them were also reported to relate diseases, only several been confirmed pathogenic genes for autism. Little known about the roles these in diseases ASD. In present study, we recruited a cohort 158 probands 163 variants 48 Of...
Abstract Background Tumor necrosis factor- α (TNF- ), a proinflammatory cytokine, is capable of activating the small GTPase RhoA, which in turn contributes to endothelial barrier dysfunction. However, underlying signaling mechanisms remained undefined. Therefore, we aimed determine role protein kinase C (PKC) isozymes mechanism RhoA activation and TNF- -induced mouse brain microvascular cell (BMEC) Methods Bend.3 cells, an immortalized line, were exposed (10 ng/mL). activity was assessed by...
The purposes of this study were three-fold: (i) to determine the contribution known genes causation a broad-spectrum pediatric drug-resistant epilepsy (DRE), (ii) compare diagnostic yield and cost among different next-generation sequencing (NGS) approaches, especially (iii) assess how NGS approaches can benefit patients by improving diagnosis treatment efficiency.This enrolled 273 DRE with no obvious acquired etiology. Seventy-four underwent whole-exome (WES), 141 had epilepsy-related gene...
Background: Febrile infection-related epilepsy syndrome (FIRES) is a fatal epileptic encephalopathy associated with super-refractory status epilepticus (SRSE). Several treatment strategies been proposed for this condition although the clinical outcomes are poor. Huge efforts from neurointensivists have focused on identifying characteristics of FIRES and to reduce mortality condition. However, role ketogenic diet (KD) in not fully understood. Methods: We performed retrospective review...
Paroxysmal kinesigenic dyskinesia (PKD) is a heterogeneous movement disorder characterized by recurrent attacks triggered sudden movement. PRRT2 has been identified as the first causative gene of PKD. However, it only responsible for approximately half affected individuals, indicating that other loci are most likely involved in etiology this disorder. To explore underlying PRRT2-negative PKD, we used combination strategy including linkage analysis, whole-exome sequencing and copy number...
Background and purpose: The clinical radiological features of myelin oligodendrocyte glycoprotein antibody (MOG-Ab) diseases vary among the patients studies. In addition, significance MOG-Ab for diagnosis, treatment, prognosis is not yet established. Therefore, we aimed to evaluate clinical, radiological, treatments outcome in Central Southern part China. Methods: A retrospective study children with disease was carried out from January 2015 October 2018. Demographics, features, treatments,...
The aim of this study was to investigate the combined effect n-3 fatty acids (EPA and DHA, at an EPA:DHA ratio 150:500) phytosterol esters (PS) on non-alcoholic liver disease (NAFLD) patients. We conducted a randomised, double-blind, placebo-controlled trial. Ninety-six NAFLD subjects were randomly assigned following groups: PS group (receiving 3·3 g/d PS); FO 450 mg EPA + 1500 DHA/d); combination DHA/d) PO (a placebo group). baseline clinical characteristics four groups similar. primary...