A5100418581- Epigenetics and DNA Methylation
- RNA modifications and cancer
- Lung Cancer Diagnosis and Treatment
- Cancer-related molecular mechanisms research
- Bladder and Urothelial Cancer Treatments
- Lung Cancer Treatments and Mutations
- Cancer Genomics and Diagnostics
- Radiomics and Machine Learning in Medical Imaging
- Genetics and Neurodevelopmental Disorders
- Cancer-related gene regulation
- Genomic variations and chromosomal abnormalities
- Pleural and Pulmonary Diseases
- Spinal Fractures and Fixation Techniques
- Cancer Immunotherapy and Biomarkers
- Bone Tumor Diagnosis and Treatments
- Medical Imaging and Pathology Studies
- Sarcoma Diagnosis and Treatment
- Spine and Intervertebral Disc Pathology
- Cerebrovascular and Carotid Artery Diseases
- Genomics and Rare Diseases
- Psychopathy, Forensic Psychiatry, Sexual Offending
- Esophageal Cancer Research and Treatment
- Autism Spectrum Disorder Research
- Genetic factors in colorectal cancer
- Orthopaedic implants and arthroplasty
Shanghai Jiao Tong University
2025
Renji Hospital
2025
First Affiliated Hospital of Anhui Medical University
2025
Anhui Medical University
2025
Zhengzhou University of Light Industry
2025
Central South University
2015-2024
Second Xiangya Hospital of Central South University
2015-2024
Affiliated Hospital of Qingdao University
2023-2024
Beijing Shijitan Hospital
2024
Capital Medical University
2024
Purpose: CT screening can reduce death from lung cancer. We sought to improve the diagnostic accuracy of cancer using ultrasensitive methods and a cancer-specific gene panel detect DNA methylation in sputum plasma.Experimental Design: This is case-control study subjects with suspicious nodules on imaging. Plasma were obtained preoperatively. Cases (n = 150) had pathologic confirmation node-negative (stages I IIA) non-small cell Controls 60) non-cancer diagnoses. detected promoter...
Purpose To test whether computer-aided diagnosis (CAD) approaches can increase the positive predictive value (PPV) and reduce false-positive rate in lung cancer screening for small nodules compared with human reading by thoracic radiologists. Materials Methods A matched case-control sample of low-dose computed tomography (CT) studies 186 participants 4–20-mm noncalcified who underwent biopsy National Lung Screening Trial (NLST) was selected. Variables used matching were age, sex, smoking...
Background: Since the inception of microvascular free tissue transfer, flap monitoring has been based on clinical signs. Color, capillary refill, and handheld Doppler have used for in postoperative period; however, subjective examination may delay recognition compromise. Tissue oximeter offers an objective method detecting vascular compromise with measurement oxygen saturation real-time perfusion. Methods: The authors reviewed 614 consecutive microsurgical flaps breast reconstruction from...
Routine clinical surveillance involves serial radiographic imaging following radical surgery in localized non-small cell lung cancer (NSCLC). However, such can detect only macroscopic disease recurrence and is frequently inconclusive. We investigated if detection of ctDNA before after resection NSCLC identifies the patients with risk relapse, furthermore, informs about response to management.We recruited a total 77 patients. A high-throughput 127 target-gene capture technology...
Abstract Purpose: Low-dose CT screening can reduce lung cancer–related mortality. However, has an FDR of nearly 96%. We sought to assess whether urine samples be a source for DNA methylation–based detection non–small cell cancer (NSCLC). Experimental Design: This nested case–control study subjects with suspicious nodules on imaging obtained plasma and preoperatively. Cases (n = 74) had pathologic confirmation NSCLC. Controls 27) noncancer diagnosis. detected promoter methylation in using...
There is currently a lack of effective biomarkers to evaluate efficacy neoadjuvant therapy (NAT) for resectable non-small cell lung cancer (NSCLC) patients. Circulating tumor DNA (ctDNA) has been investigated as non-invasive tool the assessment burden and minimal residual disease (MRD). The utility ctDNA profiling in reflecting NAT efficacy, however, not confirmed. This study explored association change with treatment response recurrence-free survival (RFS) after surgery.Eligible patients...
Abstract The relationship between patterns of RNA modifications and gastric cancer (GC) liver metastasis (GCLM) remains unclear. Here, by single‐cell sequencing, clinical sample analysis, mouse model studies, an abnormal increase in the expression acetyltransferase N‐acetyltransferase 10 (NAT10) metastatic GC cells is identified. NAT10‐mediated N4‐acetylcytidine modification CXCL2 KLF5 mRNA increases their stability. Then, secreted found to promote infiltration polarization M2‐like...
Renal injury has a strong relationship to the subsequent development of renal fibrosis. In developing fibrosis, tubular epithelial cells in kidney underwent epithelial–mesenchymal transition (EMT). Matrix metalloproteinase 7 (MMP7) was reported reduce E-cadherin and induce EMT by up-regulation β-catenin/lymphoid enhancer-binding factor 1 (LEF1) signaling. this research, we tried evaluate role resveratrol (RSV) on process Human cell HK-2 were treated with aristolochic acid (AAs) transforming...
West syndrome (WS) is a classic form of early infantile epileptic encephalopathy (EIEE) characterized by tonic spasms with clustering, arrest psychomotor development, and hypsarrhythmia on electroencephalography. Genetic defects play critical role in the pathology WS, 54 EIEE genes have been identified till date. This study was designed to uncover new candidate for syndrome.In this study, we recruited 56 Chinese families WS unknown etiology. Whole exome sequencing (WES) performed identify...
We explored the effects of progressive muscle relaxation (PMR) on anxiety, depression, and quality life (QOL) in patients with pulmonary arterial hypertension (PAH). One hundred thirty Han Chinese PAH were randomly assigned to a PMR group (<mml:math xmlns:mml="http://www.w3.org/1998/Math/MathML" id="M1"><mml:mi>n</mml:mi><mml:mo>=</mml:mo><mml:mn>65</mml:mn></mml:math>) control id="M2"><mml:mi>n</mml:mi><mml:mo>=</mml:mo><mml:mn>65</mml:mn></mml:math>). In 12-week study duration, received...
Autism spectrum disorder (ASD) is frequently comorbid with other neurological disorders such as intellectual disability (ID) or global development delay (GDD) and epilepsy. The pathogenesis of ASD complex. So far, studies have identified more than 1000 risk genes. Most them were also reported to relate diseases, only several been confirmed pathogenic genes for autism. Little known about the roles these in diseases ASD. In present study, we recruited a cohort 158 probands 163 variants 48 Of...
An easy approach was reported to achieve high mechanical properties of ultrahigh-molecular-weight polyethylene (UHMWPE)-based (PE) blend for artificial joint application without the sacrifice original excellent wear and fatigue behavior UHMWPE. The PE with desirable fluidity obtained by melt mixing UHMWPE low molecular weight (LMWPE), then processed a modified injection molding technology-oscillatory shear (OSIM). Morphological observation OSIM showed LMWPE contained well-defined...
Many cancers comprise heterogeneous populations of cells at primary and metastatic sites throughout the body. The presence or emergence distinct subclones with drug-resistant genetic epigenetic phenotypes within these can greatly complicate therapeutic intervention. Liquid biopsies peripheral blood from cancer patients have been suggested as an ideal means sampling intratumor heterogeneity for diagnostics, monitoring guidance. However, current molecular diagnostic sequencing methods are not...
To investigate effect of long noncoding RNA metastasis-associated lung adenocarcinoma transcript 1 (MALAT1) on epithelial-to-mesenchymal transition (EMT) esophageal cancer (EC) and role enhancer zeste homolog 2 (Ezh2)-Notch1 signaling pathway in the process. The expression MALAT1 was determined four EC cell lines by real-time PCR. TE-1 EC109 cells were transfected with sh-MALAT1 to inhibit or pcDNA3.1-Ezh2 overexpress Ezh2. Invasion migration assays conducted analyze metastasis, expressions...
Abstract As a calcium-dependent phospholipid binding annexin protein, A5 (Anxa5) links to the progression, metastasis, survival, and prognosis of variety cancers. Current work showed ANXA5 overexpression was positively correlated with upregulations CRKI/II RAC1 in hepatocarcinoma (HCC) patients’ tissues, which potentially enhanced clinical progression lymphatic metastasis HCC. The role action mechanism then investigated using Hca-P cell line, an ideal well-established murine model 100%...
Abstract Purpose We had previously developed highly sensitive DNA methylation detection to diagnose lung cancer in patients with pulmonary nodules. To validate this approach and determine clinical utility Chinese indeterminate nodules, we assessed the diagnostic accuracy for early stage plasma samples. Experimental design Patients CT-detected small nodules (diameter ≤ 3.0 cm) were included. Cases ( n = 163) staged IA or IB non-small cell (NSCLC), while controls 83) non-cancerous lesions....
Abstract Background Direct comparisons between Guardant360 (G360) circulating tumor DNA (ctDNA) and FoundationOne (F1) biopsy genomic profiling in metastatic colorectal cancer (mCRC) are limited. We aim to assess the concordance across overlapping genes tested both F1 G360 patients with mCRC. Materials Methods retrospectively analyzed 75 mCRC who underwent testing. evaluated among gene mutations by three categories of patients: untreated, treated without, EGFR inhibitors, while considering...