A5100681720- Epigenetics and DNA Methylation
- Cancer Immunotherapy and Biomarkers
- Lung Cancer Treatments and Mutations
- Cancer Cells and Metastasis
- RNA modifications and cancer
- Multiple and Secondary Primary Cancers
- Gut microbiota and health
- Mesenchymal stem cell research
- MicroRNA in disease regulation
- Cancer Genomics and Diagnostics
- Cancer, Hypoxia, and Metabolism
- Sarcoma Diagnosis and Treatment
- RNA Research and Splicing
- Cancer-related molecular mechanisms research
- Lung Cancer Diagnosis and Treatment
- Extracellular vesicles in disease
- Virus-based gene therapy research
- Infectious Aortic and Vascular Conditions
- RNA and protein synthesis mechanisms
- Axon Guidance and Neuronal Signaling
- Circular RNAs in diseases
- Proteoglycans and glycosaminoglycans research
- Reconstructive Surgery and Microvascular Techniques
- Medical Imaging and Pathology Studies
- Aortic Disease and Treatment Approaches
Second Xiangya Hospital of Central South University
2015-2025
Central South University
2015-2025
Hunan Cancer Hospital
2023
Gansu Provincial Hospital
2023
First Affiliated Hospital of GuangXi Medical University
2023
Guangxi Medical University
2023
Hong Kong Baptist University
2021
University of Hong Kong
2014
Jinan University
2014
Queen's University Belfast
2009-2011
Metastasis is the main cause of lung cancer mortality. Bone marrow-derived mesenchymal stem cells (BMSCs) are a component microenvironment and contribute to progression. Intratumoral hypoxia affects both stromal cells. Exosomes recognized as mediators intercellular communication. Here, we aim further elucidate communication between BMSC-derived exosomes in hypoxic niche. Exosomal miRNA profiling was performed using microRNA array. Lung an vivo mouse syngeneic tumor model were used evaluate...
Routine clinical surveillance involves serial radiographic imaging following radical surgery in localized non-small cell lung cancer (NSCLC). However, such can detect only macroscopic disease recurrence and is frequently inconclusive. We investigated if detection of ctDNA before after resection NSCLC identifies the patients with risk relapse, furthermore, informs about response to management.We recruited a total 77 patients. A high-throughput 127 target-gene capture technology...
The objectives of this study were to develop a three-dimensional acellular cartilage matrix (ACM) and investigate its possibility for use as scaffold in tissue engineering. Bovine articular was decellularized sequentially with trypsin, nuclease solution, hypotonic buffer, Triton x 100 solution; molded freeze-drying process; cross-linked by ultraviolet irradiation. Histological biochemical analysis showed that the ACM devoid cells still maintained collagen glycosaminoglycan components...
We explored the effects of progressive muscle relaxation (PMR) on anxiety, depression, and quality life (QOL) in patients with pulmonary arterial hypertension (PAH). One hundred thirty Han Chinese PAH were randomly assigned to a PMR group (<mml:math xmlns:mml="http://www.w3.org/1998/Math/MathML" id="M1"><mml:mi>n</mml:mi><mml:mo>=</mml:mo><mml:mn>65</mml:mn></mml:math>) control id="M2"><mml:mi>n</mml:mi><mml:mo>=</mml:mo><mml:mn>65</mml:mn></mml:math>). In 12-week study duration, received...
Abstract Bone marrow mesenchymal stem cells (BMSCs) are multipotent stromal that can differentiate into a variety of cell types. BMSCs chemotactically guided towards the cancer and contribute to formation microenvironment. The homing was affected by various factors. Disseminated tumour (DTCs) in distant organs, especially bone marrow, source metastasis relapse. DTC survival is also determined Here we aim elucidate how cancer-educated promote at primary sites sites. We highlight dynamic...
Lung is colonized by a diverse array of microbes and the lung microbiota profoundly involved in development respiratory diseases. There little knowledge about role dysbiosis cancer. In this study, we performed metagenomic sequencing on bronchoalveolar lavage (BAL) from two different sampling methods non-small cell cancer (NSCLC) patients non-cancer controls. We found obvious variation between bronchoscopy samples lobectomy samples. Oral taxa can be both higher abundance oral Although NSCLC...
Abstract As the Human Microbiome Project (HMP) progresses, relationship between microbes and human health has been receiving increasing attention. A growing number of reports support correlation cancer microbes. However, most studies have focused on bacteria, rather than fungal communities. In this study, we studied alteration in lung mycobiome patients with non-small-cell (NSCLC) using metagenomic sequencing qPCR. The higher diversity more complex network were observed NSCLC. addition,...
Bone marrow-derived mesenchymal stem cells (BMSCs, also known as bone stromal cells) are to be a component of the tumor microenvironment. BMSCs multipotent that can differentiate into variety cell types, including osteocytes, chondrocytes, adipocytes, epithelial and endothelial cells. Stem found in niches or transplanted injured tissues constantly encounter hypoxic stress. Areas with very low no oxygen pressure exist solid tumors. The differentiation capacity under conditions remains...
Abstract Purpose We had previously developed highly sensitive DNA methylation detection to diagnose lung cancer in patients with pulmonary nodules. To validate this approach and determine clinical utility Chinese indeterminate nodules, we assessed the diagnostic accuracy for early stage plasma samples. Experimental design Patients CT-detected small nodules (diameter ≤ 3.0 cm) were included. Cases ( n = 163) staged IA or IB non-small cell (NSCLC), while controls 83) non-cancerous lesions....
Abstract Eph receptors constitute the largest family of receptor tyrosine kinases, comprising 14 distinct members classified into two subgroups: EphAs and EphBs.. Despite their essential functions in normal physiological processes, accumulating evidence suggests that involvement cancer is characterized by a dual often contradictory nature. Research indicates Eph/ephrin bidirectional signaling influences cell–cell communication, subsequently regulating cell migration, adhesion,...
Abstract Background Non‐viral methods of gene delivery have been an attractive alternative to virus‐based therapy. However, the vectors that are currently available drawbacks limiting their therapeutic application. Methods We developed a self‐assembled non‐viral carrier, poly‐ L ‐lysine modified iron oxide nanoparticles (IONP‐PLL), which is formed by modifying surface nanoparticles. The ability IONP‐PLL bind DNA was determined ratio‐dependent retardation in agarose gel and co‐sedimentation...
Bone marrow mesenchymal stem cells (BMSCs) represent an important source of for tissue repair. The tropism these to the sites injury and tumors has been well established. Their tumor-homing properties make BMSCs good candidates as antitumor agent delivery vehicles. In this study, we showed that have ability migrate toward various cancer cells, including prostate in vitro vivo incorporating into tumor mass. When infected with herpes simplex virus thymidine kinase (TK) gene by lentiviral...
CD164 (Endolyn) is a sialomucin, which has been found to play roles in regulating proliferation, adhesion, and differentiation of hematopoietic stem cells. Possible association with solid cancer development remains unknown.We first studied expression biopsies from colorectal cancer, breast, ovary patients by semi-quantitative immunohistochemistry, that was strongly expressed all the samples compared matching normal colon tissues. The possible were further investigated using well-established...
// Yafei Dai 1, 2 , Lujuan Wang Jingqun Tang 3 Pengfei Cao Zhaohui Luo 2, 5 Jun Sun Abraha Kiflu Buqing Sai Meili Zhang Fan Guiyuan Li 4 Juanjuan Xiang 1 Hunan Cancer Hospital and The Affiliated of Xiangya School Medicine, Central South University, Changsha, Hunan, PR China Research Institute, Key Laboratory Carcinogenesis Invasion Ministry Education, Health, Department Thoracic Surgery, Second Hospital, Nonresolving Inflammation Cancer, Neurology, Correspondence to: Xiang, e-mail:...
Abstract Background To explore the possible carcinogenesis and help better diagnose treat patients with synchronous multiple primary lung cancers (sMPLC), we systematically investigated genetic DNA methylation profiles of early-stage sMPLC single cancer (SPLC) explored immune in tumor microenvironment. Methods Hundred ninety-one 191 nodules SPLC group 132 295 were enrolled. All samples subjected to wide panel-genomic sequencing. Genome-wide was assessed using Infinium Human Methylation 850 K...
Abstract Background Aortoesophageal fistula (AEF) is an extremely rare and highly fatal complication leading to a high risk of morbidity mortality. Successful management AEF after esophagectomy for esophageal carcinoma has rarely been reported in the literature. Case presentation Here we present case 44-year-old female with complications carcinoma, mainly presented as vomiting blood. Both computed tomographic tomography angiography chest showed bilateral pleural effusion atelectasis, while...
As regulators in gene expression, microRNAs take part most biological processes including cell differentiation, apoptosis, cycle, and epithelial‐to‐mesenchymal transition (EMT). In order to evaluate their roles EMT process, microRNA expression profile changes induced by EGF or TGF‐β treatment on nasopharyngeal carcinoma HK‐1 were analyzed, miR‐21, miR‐148a, miR‐505, miR‐1207‐5p found be upregulated growth factors‐induced process. miR‐21 is already known as an oncogenic miRNA promote...
Approximately 30% of patients diagnosed with stage Ia-b NSCLC die recurrent disease after surgery. This study aimed to identify immune-related biomarkers that might predict tumor recurrence in within 40 months curative resection.Gene expression data samples was retrieved from the TCGA database, GEO databases, and Second Xiangya hospital (XXEYY) database. 22 types tumors infiltrating immune cells immune-associated genes were investigated using CIBERSORT, immunohistochemical staining, GSEA...
A new ursane-type triterpenoid saponin, flaccidoside IV (1), and three oleanane-type saponins, flaccidosides V-VII (2-4), along with 17 known saponins (5-21), were isolated from the rhizomes of Anemone flaccida. The structures determined based on spectroscopic analyses chemical methods. All tested for their inhibitory activities lipopolysaccharide-induced nitric oxide production in RAW264.7 macrophages, several bisdesmosidic (2, 7, 10) showed significant activities, which indicated they had...
Calpain 1 (CAPN1) has been found to be a promoter of cancer progression. PTPN1 as physiological target molecule CAPN1 plays dephosphorylated role on multiple receptor tyrosine kinases. This study aimed reveal the effects CAPN1/PTPN1 malignant phenotype and EGFR-TKI resistance lung adenocarcinoma (LUAD) cells.A total 84 primary LUAD tissues paired paracancerous normal were collected. Quantitative real-time PCR (qRT-PCR) immunohistochemical (IHC) methods used measure expression in tissues....