A5101519434- Multiple Myeloma Research and Treatments
- Liver Disease Diagnosis and Treatment
- Gut microbiota and health
- Cardiovascular Function and Risk Factors
- Cancer therapeutics and mechanisms
- Atherosclerosis and Cardiovascular Diseases
- Drug Transport and Resistance Mechanisms
- Cardiac Fibrosis and Remodeling
- Histone Deacetylase Inhibitors Research
- Peroxisome Proliferator-Activated Receptors
- Protein Degradation and Inhibitors
- Diet, Metabolism, and Disease
- Lipid metabolism and disorders
- Cancer, Lipids, and Metabolism
- Parasitic Infections and Diagnostics
- Pharmacological Effects of Natural Compounds
- Signaling Pathways in Disease
- Cholesterol and Lipid Metabolism
- NF-κB Signaling Pathways
- Peptidase Inhibition and Analysis
- Oral and gingival health research
- Pluripotent Stem Cells Research
- Ubiquitin and proteasome pathways
- Photodynamic Therapy Research Studies
- Metabolism, Diabetes, and Cancer
Central South University
2018-2025
Ministry of Education of the People's Republic of China
2022-2025
Third Affiliated Hospital of Guangzhou Medical University
2020-2024
Guangzhou Medical University
2020-2024
Xiangya Hospital Central South University
2019-2023
Osaka University
2015-2023
University of Arkansas for Medical Sciences
2023
Cleveland Clinic Lerner College of Medicine
2023
National Health and Family Planning Commission
2018-2022
Hunan Cancer Hospital
2020-2021
Abstract Background Gut microbiome alterations are closely related to human health and linked a variety of diseases. Although great efforts have been made understand the risk factors for multiple myeloma (MM), little is known about role gut its metabolic functions in development MM. Results Here, cohort newly diagnosed patients with MM healthy controls (HCs), significant differences metagenomic composition were discovered, first time, higher bacterial diversity Specifically,...
NEK2 is associated with drug resistance in multiple cancers. Our previous studies indicated that high confers inferior survival myeloma (MM); thus, a better understanding of the mechanisms by which induces MM required. In this study, we discovered enhances cell autophagy, and combination autophagy inhibitor chloroquine (CQ) chemotherapeutic bortezomib (BTZ) significantly prevents NEK2-induced cells. Interestingly, was found to bind stabilize Beclin-1 protein but did not affect its mRNA...
Abstract Metabolites in the tumor microenvironment are a critical factor for progression. However, lack of knowledge about metabolic profile bone marrow (BM) multiple myeloma (MM) limits our understanding MM Here, we show that glycine concentration BM is elevated due to collagen degradation mediated by cell-secreted matrix metallopeptidase 13 (MMP13), while level linked cells utilize channel protein solute carrier family 6 member 9 (SLC6A9) absorb extrinsic subsequently involved synthesis...
Summary The serine synthesis pathway (SSP) is active in multiple cancers. Previous study has shown that bortezomib (BTZ) resistance associated with an increase the SSP myeloma (MM) cells; however, underlying mechanisms of SSP‐induced BTZ remain unclear. In this study, we found phosphoglycerate dehydrogenase (PHGDH), first rate‐limiting enzyme SSP, was significantly elevated CD138 + cells derived from patients relapsed MM. Moreover, high PHGDH conferred inferior survival We also...
Lung is colonized by a diverse array of microbes and the lung microbiota profoundly involved in development respiratory diseases. There little knowledge about role dysbiosis cancer. In this study, we performed metagenomic sequencing on bronchoalveolar lavage (BAL) from two different sampling methods non-small cell cancer (NSCLC) patients non-cancer controls. We found obvious variation between bronchoscopy samples lobectomy samples. Oral taxa can be both higher abundance oral Although NSCLC...
Abstract Thrombocytopenia is a major complication in subset of patients with multiple myeloma (MM). However, little known about its development and significance during MM. Here, we show thrombocytopenia linked to poor prognosis In addition, identify serine, which released from MM cells into the bone marrow microenvironment, as key metabolic factor that suppresses megakaryopoiesis thrombopoiesis. The impact excessive serine on mainly mediated through suppression megakaryocyte (MK)...
Abstract Nasopharyngeal carcinoma (NPC) has the highest rate of metastasis among head and neck cancers, distant is major reason for treatment failure. We have previously shown that high cyclooxygenase‐2 (COX‐2) expression associated with a poor prognosis patients NPC inhibits chemotherapy‐induced senescence in cells. In this study, we found COX‐2 was upregulated cancer‐associated fibroblasts (CAFs) derived from by RNA‐Seq. Furthermore, elevated CAF detected survival using...
Abstract Although patients with nonalcoholic fatty liver disease have been reported to cardiac dysfunction, and appropriate model has not reported. We established a novel mouse of diet-induced steatohepatitis-related cardiomyopathy evaluated the effect pemafibrate. C57Bl/6 male mice were fed (1) chow diet (C), (2) high-fat, high-cholesterol, high-sucrose, bile acid (NASH diet; N), or (3) N pemafibrate 0.1 mg/kg (NP) for 8 weeks. In liver, macrophage infiltration fibrosis in was observed...
Abstract It has been previously shown that (never in mitosis gene A)‐related kinase 2 ( NEK2 ) is upregulated multiple myeloma (MM) and contributes to drug resistance. However, the mechanisms behind this upregulation remain poorly understood. In study, it found amplification of hypermethylation distal CpG islands its promoter correlate strongly with increased expression. Patients have a poor rate survival often exhibit TP53 deletion, which an independent prognostic factor MM. This...
Diabetic cardiomyopathy (DCM) is initially characterized by early diastolic dysfunction, left ventricular remodeling, hypertrophy, and myocardial fibrosis, it eventually clinical heart failure. MicroRNAs (miRNAs), endogenous small noncoding RNAs, play significant roles in diabetes mellitus (DM). However, still largely unknown about the mechanism that links miRNAs development of DCM. Here, we aimed to elucidate underlying potential role microRNA-340-5p DCM db/db mouse, which a commonly used...
The gut microbiome has been found to play a crucial role in the treatment of multiple myeloma (MM), which is still considered incurable due drug resistance. In previous studies, we demonstrated that intestinal nitrogen-recycling bacteria are enriched patients with MM. However, their MM relapse remains unclear. This study highlights specific enrichment Citrobacter freundii (C. freundii) relapsed Through fecal microbial transplantation experiments, demonstrate C. plays critical inducing...
Multiple myeloma (MM) is a plasma cell malignancy characterized by clonal proliferation in the bone marrow (BM). Previously, it was reported that G‑protein‑coupled receptor 4 (LGR4) contributed to early hematopoiesis and associated with poor prognosis patients MM. However, mechanism of homing migration, which critical for MM progression, remains unclear. In present study, counting, cycle BrdU assays were performed evaluate proliferation. Transwell assay Xenograft mouse models migration...
Fasting and postprandial hypertriglyceridemia (PHTG) are caused by the accumulation of triglyceride (TG)-rich lipoproteins their remnants, which have atherogenic effects. Fibrates can improve fasting PHTG; however, reduction remnants is clinically needed to health outcomes. In current study, we investigated effects a novel selective peroxisome proliferator-activated receptor α modulator (SPPARMα), K-877 (Pemafibrate), on PHTG remnant metabolism.Male C57BL/6J mice were fed high-fat diet (HFD)...
Aim: A direct oral anti-coagulant, FXa inhibitor, has been applied to the clinical treatment of myocardial infarction (MI). Experimental studies in mice indicated that inhibitors reduced atherosclerosis and prevented cardiac dysfunction after coronary ligation. These suggested protease-activated receptor (PAR) 2, a major activated FX, may play an important role remodeling.
Resistance to radiotherapy and chemotherapy currently represents one of the major reasons for therapeutic failure in nasopharyngeal carcinoma (NPC). However, mechanisms underlying resistance NPC remain unclear. In this study, cell counting assay, cycle assay senescence associated β-galactosidase activity were performed evaluate growth, proliferation senescence, respectively. We found that aberrant expression cyclooxygenase-2 (COX-2) was with a poor outcome recurrance patients NPC. cells,...
Abstract Nasopharyngeal carcinoma (NPC) is a common malignant tumor in southern China and Southeast Asia, but the molecular mechanism of its pathogenesis poorly understood. Our previous work demonstrated that NEK2 overexpressed multiple cancers. However, how involves NPC development remains to be elucidated. In this study, we firstly identified NEK2, located at +1q32‐q33, late event pathogenesis, stage III‐IV paired sequential recurrent patients with by immunohistochemistry. Furthermore,...
Abstract Background B-cell CLL/lymphoma 6 member B (BCL6B) operates as a sequence-specific transcriptional repressor within the nucleus, playing crucial roles in various biological functions, including tumor suppression, immune response, stem cell self-renew, and vascular angiogenesis. However, whether BCL6B is involved endothelial (EC) development has remained largely unknown. ETS variant transcription factor 2 (ETV2) well known to facilitate EC differentiation. This study aims determine...
Non-alcoholic fatty liver disease is strongly associated with obese and type 2 diabetes. It has been reported that an oxidized cholesterol, 7-ketocholesterol (7KC), might cause inflammatory response in macrophages plasma 7KC concentration were higher patients cardiovascular diseases or Therefore, we have decided to test whether small amount of diet induce hepatic steatosis inflammation two types models. We found addition 0.01% either chow (CD, regular 1% cholesterol) western (WD, high fat...
Cardiac remodeling has no established therapies targeting inflammation. CD4+ T-cell subsets have been reported to play significant roles in healing process after ischemic myocardial injury, but their detailed mechanisms of activation remain unknown. To explore immune reactions during cardiac remodeling, we applied a non-surgical model coronary heart disease (CHD) induced by high-fat diet (HFD-CHD) SR-BI−/−/ApoeR61h/h mice. Flow cytometry analyses throughout the period progressive dysfunction...
Pneumonia accounts for a significant cause of morbidity and mortality in multiple myeloma (MM) patients. It has been previously shown that intestinal Klebsiella pneumonia (K. pneumonia) enriches MM promotes progression. However, what role the altered gut microbiota plays with remains unknown. Here, we show K. is significantly enriched pneumonia. This links to incidence MM, colonization contributes 5TGM1 mice model. Further targeted metabolomic assays reveal elevated level glutamine, which...