A5032432567- Inflammatory mediators and NSAID effects
- Pulmonary Hypertension Research and Treatments
- NF-κB Signaling Pathways
- Fatty Acid Research and Health
- Congenital heart defects research
- Eicosanoids and Hypertension Pharmacology
- Ion Channels and Receptors
- Nitric Oxide and Endothelin Effects
- PI3K/AKT/mTOR signaling in cancer
- Antiplatelet Therapy and Cardiovascular Diseases
- Photodynamic Therapy Research Studies
- Food Quality and Safety Studies
- Asthma and respiratory diseases
- RNA modifications and cancer
- Cytokine Signaling Pathways and Interactions
- Adenosine and Purinergic Signaling
- Synthesis and Characterization of Heterocyclic Compounds
- Magnesium in Health and Disease
- Cardiovascular, Neuropeptides, and Oxidative Stress Research
- Peptidase Inhibition and Analysis
- Sodium Intake and Health
- Circadian rhythm and melatonin
- Garlic and Onion Studies
- Lipid metabolism and biosynthesis
- Phytochemical and Pharmacological Studies
Jiangnan University
2023-2025
Guangzhou Medical University
2019-2023
First Affiliated Hospital of Guangzhou Medical University
2020-2023
Tianjin Medical University
2017-2023
State Key Laboratory of Respiratory Disease
2019-2023
Chinese Academy of Sciences
2016-2021
University of Chinese Academy of Sciences
2016-2021
Shanghai Institute of Nutrition and Health
2018-2021
Nantong University
2020
Shanghai Institutes for Biological Sciences
2016-2019
Research Article27 March 2017Open Access Transparent process Niacin ameliorates ulcerative colitis via prostaglandin D2-mediated D prostanoid receptor 1 activation Juanjuan Li Department of Gastroenterology, Ruijin Hospital affiliated to Shanghai Jiao Tong University School Medicine, Shanghai, China Key Laboratory Food Safety Research, Institute for Nutritional Sciences, Institutes Biological Chinese Academy Search more papers by this author Deping Kong Qi Wang Wei Wu Yanping Tang Tingting...
Rationale: Vascular remodeling, including smooth muscle cell hypertrophy and proliferation, is the key pathological feature of pulmonary arterial hypertension (PAH). Prostaglandin I2 analogs (beraprost, iloprost, treprostinil) are effective in treatment PAH. Of note, clinically favorable effects treprostinil severe PAH may be attributable to concomitant activation DP1 (D prostanoid receptor subtype 1).Objectives: To study role progression its underlying mechanism.Methods: levels were...
The kinetic participation of macrophages is critical for inflammatory resolution and recovery from myocardial infarction (MI), particularly with respect to the transition M1 M2 phenotype; however, underlying mechanisms are poorly understood. In this study, we found that deletion prostaglandin (PG) D2 receptor subtype 1 (DP1) in retarded polarization, antiinflammatory cytokine production, different models, including MI model. DP1 up-regulated proinflammatory genes expression via JAK2/STAT1...
Pulmonary arterial hypertension (PAH) is a life-threatening disease characterized by progressive pulmonary artery (PA) remodeling. T helper 2 cell (Th2) immune response involved in PA remodeling during PAH progression. Here, we found that CRTH2 (chemoattractant receptor homologous molecule expressed on Th2 cell) expression was up-regulated circulating CD3+CD4+ cells patients with idiopathic and rodent models. disruption dramatically ameliorated different mouse deficiency suppressed...
An appropriate inflammatory response is necessary for cardiac healing after acute myocardial infarction (MI). Resolvin E1 (RvE1) an anti-inflammatory and pro-resolution lipid mediator derived from eicosapentaenoic acid. Here we have investigated the effects of RvE1 on recovery function MI in mice.Acute was induced by surgical ligation left anterior descending artery male C57BL/6 mice. (5 ng·g-1 ·day-1 ; i.p.) given to mice at different times following MI. Cardiac monitored transthoracic...
Abstract Nasopharyngeal carcinoma (NPC) has the highest rate of metastasis among head and neck cancers, distant is major reason for treatment failure. We have previously shown that high cyclooxygenase‐2 (COX‐2) expression associated with a poor prognosis patients NPC inhibits chemotherapy‐induced senescence in cells. In this study, we found COX‐2 was upregulated cancer‐associated fibroblasts (CAFs) derived from by RNA‐Seq. Furthermore, elevated CAF detected survival using...
BACKGROUND: Vascular calcification contributes to increased cardiovascular morbidity and mortality in patients with chronic kidney disease, diabetes, atherosclerosis. Currently, there are no effective therapeutic strategies prevent or reverse vascular calcification. TRPV4 (transient receptor potential channel V4), a key Ca 2+ -permeable channel, plays an important role various diseases. However, the mechanism of have not yet been elucidated. METHODS: The effects on were explored vitro vivo....
Abstract Two distinct monocyte (Mo)/macrophage (Mp) subsets (Ly6C low and Ly6C high ) orchestrate cardiac recovery process following myocardial infarction (MI). Prostaglandin (PG) E 2 is involved in the Mo/Mp-mediated inflammatory response, however, role of its receptors Mos/Mps healing remains to be determined. Here we show that pharmacological inhibition or gene ablation Ep3 receptor mice suppresses accumulation infarcted hearts. deletion markedly attenuates after MI by reducing...
Mechanical insults, such as stent implantation, can induce endothelial injury, vascular inflammation, and ultimately lead to neointimal hyperplasia. Resolvin E1 (RvE1), derived from the ω3 fatty acid eicosa- pentaenoic acid, facilitate resolution of inflammation in many settings. We therefore aimed determine if there was a role for RvE1 preventing formation after arterial injury understand underlying mechanisms. Vascular hyperplasia were induced by wire femoral arteries mice. Administration...
Resistance to radiotherapy and chemotherapy currently represents one of the major reasons for therapeutic failure in nasopharyngeal carcinoma (NPC). However, mechanisms underlying resistance NPC remain unclear. In this study, cell counting assay, cycle assay senescence associated β-galactosidase activity were performed evaluate growth, proliferation senescence, respectively. We found that aberrant expression cyclooxygenase-2 (COX-2) was with a poor outcome recurrance patients NPC. cells,...
Blood pressure often rises with aging, but exact mechanisms are still not completely understood. With the level of proinflammatory cytokines increases in T lymphocytes. Prostaglandin D2, a proresolution mediator, suppresses Type 1 helper (Th1) through D-prostanoid receptor (DP1). In this study, we aimed to investigate role prostaglandin D2/DP1 axis cells on age-related hypertension.To clarify physiological and pathophysiological roles DP1 peripheral blood samples were collected from young...
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Inflammatory bowel disease (IBD) is associated with an increased risk for thromboembolism, platelet activation, and abnormalities in number size. In colitis, platelets can extravasate into the colonic interstitium. We generated a mouse specific deletion of cyclooxygenase (COX)-1 megakaryocytes/platelets [(COX-1 conditional knockout (cKO)] to clarify role activation development inflammation fibrosis dextran sodium sulfate (DSS)–induced colitis. The activity index was assessed, specimens were...
Abstract Endothelial injury or dysfunction is an early event in the pathogenesis of atherosclerosis. Epidemiological and animal studies have shown that 2, 3, 7, 8‐tetrachlorodibenzo‐ p ‐dioxin (TCDD) exposure increases morbidity mortality from chronic cardiovascular diseases, including However, whether how TCDD causes endothelial remains largely unknown. Cultured human umbilical vein cells (HUVECs) were exposed to different doses TCDD, cell apoptosis was examined. We found treatment...
Niacin is a well established drug used to lower cholesterol and prevent cardiovascular disease events. However, niacin also causes cutaneous flushing side effects due release of the proresolution mediator prostaglandin D2 (PGD2). Recent randomized clinical trials have demonstrated that addition with laropiprant [a PGD2 receptor subtype 1 (DP1) blocker] statin-based therapies does not significantly decrease risk events, but increases serious adverse Here, we tested whether, how, beneficial on...
It has been identified that arginine vasopressin (AVP), receptor 2(V2R), and the aquaporin 2 (AQP2) signaling pathway in inner ear play important roles hearing balance functions through regulating endolymph equilibrium; however, contributions of this to development motion sickness are unclear. The present study was designed investigate whether activation AVP-V2R-AQP2 is involved induction mozavaptan, a V2R antagonist, could reduce sickness. We found both rotatory stimulus intraperitoneal AVP...
To explore the source, role and specific mechanism of IL-35 its downstream molecules in development pulmonary hypertension.8-10 weeks male mice were undergoing hypoxia combined with SU5416 (HySu) to establish a hypertension (PH) model. The phenotype PH was measured by immunohistochemistry immunofluorescence staining. levels two subunits (EBI3 p35 subunits) lung tissue real-time PCR western blotting. EBI3 monoclonal antibody administrated as neutralization offset systemic expression....
2,3,7,8-Tetrachlorodibenzo-p-dioxin (TCDD) is an environmental pollutant that causes cardiovascular toxicity. The phenotypic transformation of vascular smooth muscle cells (VSMCs) from the contractile to synthetic phenotype a hallmark response injury. However, precise role and molecular mechanism TCDD in remodeling remains unknown. In present study, we found treatment promoted VSMC transition exaggerated neointimal hyperplasia after wire injury mice. enhanced entry into cell cycle G0/G1...