A5101786368- Inflammatory mediators and NSAID effects
- Eicosanoids and Hypertension Pharmacology
- Adipose Tissue and Metabolism
- Liver Disease Diagnosis and Treatment
- Diet, Metabolism, and Disease
- Pulmonary Hypertension Research and Treatments
- Metabolism, Diabetes, and Cancer
- Sulfur Compounds in Biology
- Adipokines, Inflammation, and Metabolic Diseases
- Peptidase Inhibition and Analysis
- Cardiac Imaging and Diagnostics
- Peroxisome Proliferator-Activated Receptors
- Traditional Chinese Medicine Analysis
- Molecular Sensors and Ion Detection
- Thyroid Disorders and Treatments
- Hormonal Regulation and Hypertension
- Neuropeptides and Animal Physiology
- Pituitary Gland Disorders and Treatments
- Regulation of Appetite and Obesity
- Retinopathy of Prematurity Studies
- Cancer, Stress, Anesthesia, and Immune Response
- Selenium in Biological Systems
- Pregnancy and preeclampsia studies
- Cholesterol and Lipid Metabolism
- Cancer Mechanisms and Therapy
Harbin Medical University
2023-2025
First Affiliated Hospital of Harbin Medical University
2023-2025
Affiliated Hospital of Hebei University
2024-2025
Beth Israel Deaconess Medical Center
2021-2024
Harvard University
2022-2024
Nanjing University of Chinese Medicine
2016-2024
Jiangyin People's Hospital
2024
Suzhou Traditional Chinese Medicine Hospital
2020-2024
Lanzhou University
2020-2024
Tianjin Medical University
2016-2024
Spexin mRNA and protein are widely expressed in rat tissues associate with weight loss rodents of diet-induced obesity. Its location endocrine epithelial cells has also been suggested. is a novel peptide that involves Therefore, we aimed to examine its expression human test whether spexin could have role glucose lipid metabolism type 2 diabetes mellitus (T2DM). The the gene immunoreactivity adrenal gland, skin, stomach, small intestine, liver, thyroid, pancreatic islets, visceral fat, lung,...
Adipose thermogenesis is repressed in obesity, reducing the homeostatic capacity to compensate for chronic overnutrition. Inflammation inhibits adipose thermogenesis, but little known about how this occurs. Here we showed that innate immune transcription factor IRF3 a strong repressor of thermogenic gene expression and oxygen consumption adipocytes. achieved by driving ubiquitin-like modifier ISG15, which became covalently attached glycolytic enzymes, thus their function decreasing lactate...
Obesity-induced inflammation causes metabolic dysfunction, but the mechanisms remain elusive. Here we show that innate immune transcription factor interferon regulatory (IRF3) adversely affects glucose homeostasis through induction of endogenous FAHFA hydrolase androgen induced gene 1 (AIG1) in adipocytes. Adipocyte-specific knockout IRF3 protects male mice against high-fat diet-induced insulin resistance, whereas overexpression or AIG1 adipocytes promotes resistance on a diet. Furthermore,...
Pulmonary arterial hypertension (PAH) is commonly associated with chronic hypoxemia in disorders such as obstructive pulmonary disease (COPD). Prostacyclin analogs are widely used the management of PAH patients; however, clinical efficacy and long-term tolerability some prostacyclin may be compromised by concomitant activation E-prostanoid 3 (EP3) receptor. Here, we found that EP3 expression upregulated smooth muscle cells (PASMCs) human distal arteries (PAs) response to hypoxia. Either...
Research Article15 January 2018Open Access Source DataTransparent process CRTH2 promotes endoplasmic reticulum stress-induced cardiomyocyte apoptosis through m-calpain Shengkai Zuo Department of Pharmacology, Key Laboratory Immune Microenvironment and Disease (Ministry Education), School Basic Medical Sciences, Tianjin University, Tianjin, China Food Safety Research, Institute for Nutritional Shanghai Institutes Biological Chinese Academy Shanghai, Search more papers by this author Deping...
Rationale: Vascular remodeling, including smooth muscle cell hypertrophy and proliferation, is the key pathological feature of pulmonary arterial hypertension (PAH). Prostaglandin I2 analogs (beraprost, iloprost, treprostinil) are effective in treatment PAH. Of note, clinically favorable effects treprostinil severe PAH may be attributable to concomitant activation DP1 (D prostanoid receptor subtype 1).Objectives: To study role progression its underlying mechanism.Methods: levels were...
Gluconeogenesis is drastically increased in patients with type 2 diabetes and accounts for fasting plasma glucose concentrations. Circulating levels of prostaglandin (PG) F2α are also markedly elevated diabetes; however, whether how PGF2α regulates hepatic metabolism remain unknown. Here, we demonstrated that receptor (F-prostanoid [FP]) was upregulated the livers mice upon fasting- diabetic stress. Hepatic deletion FP suppressed fasting-induced gluconeogenesis, whereas overexpression...
Inflammation has profound but poorly understood effects on metabolism, especially in the context of obesity and nonalcoholic fatty liver disease (NAFLD). Here, we report that hepatic interferon regulatory factor 3 (IRF3) is a direct transcriptional regulator glucose homeostasis through induction Ppp2r1b , component serine/threonine phosphatase PP2A, subsequent suppression production. Global ablation IRF3 mice high-fat diet protected against both steatosis dysglycemia, whereas...
Lower-grade glioma (LGG) exhibits significant heterogeneity in clinical outcomes, and current prognostic markers have limited predictive value. Despite the growing recognition of histone modifications tumor progression, their role LGG remains poorly understood. This study aimed to develop a modification-based risk signature investigate its relationship with drug sensitivity guide personalized treatment strategies. We performed single-cell RNA sequencing analysis on samples (n = 4)...
Objective: To observe the effect of digital treadmill on lower limb motor function in patients with ischemic stroke. Method: This was a clinical comparative study. A total 60 stroke at Hebei University Hospital were selected from October 2020 to September 2022 and randomly divided observation group control group. The given conventional rehabilitation therapy, receiving training. Both groups assessed using Holden Functional Ambulation Category Scale(FAC), gait analysis system, dynamic balance...
Abstract Background Neutrophil extracellular traps (NETs) are composed of DNA chains from neutrophils and associated proteolytic enzymes, which play an important role in cancer metastasis. However, the molecular mechanism NET-mediated lung metastasis triple-negative breast (TNBC) remains unclear. Methods The expression levels NETs specimens serum were analyzed compared with normal samples. Single-cell sequencing bioinformatics analysis was conducted to identify differentially expressed genes...
Mechanical insults, such as stent implantation, can induce endothelial injury, vascular inflammation, and ultimately lead to neointimal hyperplasia. Resolvin E1 (RvE1), derived from the ω3 fatty acid eicosa- pentaenoic acid, facilitate resolution of inflammation in many settings. We therefore aimed determine if there was a role for RvE1 preventing formation after arterial injury understand underlying mechanisms. Vascular hyperplasia were induced by wire femoral arteries mice. Administration...
Abstract Objective This study aimed to explore the relationship of thyroid function and glucose metabolism investigate changes in after National Metabolic Management Center (MMC) management type 2 diabetic mellitus (T2DM). Methods A total 2000 euthyroid participants from MMC Shanghai General Hospital a community physical examination were recruited. They categorized into four groups: normal tolerance (NGT, n = 132), prediabetes (N 147), DM well‐controlled (T2DM with glycosylated hemoglobin...
Breast angiosarcoma is a rare malignancy of endovascular origin, accounting for less than 1% all mammary cancers. Our aim was to explore clinicopathological features and the factors associated with prognosis.We extracted information from Surveillance, Epidemiology, End Results Program (SEER) patients breast between 2004 2015. Chi-square analysis used compare in patients. Overall survival (OS) assessed using Kaplan Meier method. Univariate multivariate analyses were performed evaluate...
Although the importance of macrophages in nonalcoholic fatty liver disease (NAFLD) and type 2 diabetes mellitus (T2DM) has been recognized, how affect hepatocytes remains elusive. Mineralocorticoid receptor (MR) implicated to play important roles NAFLD T2DM. However, cellular molecular mechanisms are largely unknown. We report that myeloid MR knockout (MRKO) improves glucose intolerance, insulin resistance, hepatic steatosis obese mice. Estrogen signaling is sufficient necessary for such...
Abstract Endothelial injury or dysfunction is an early event in the pathogenesis of atherosclerosis. Epidemiological and animal studies have shown that 2, 3, 7, 8‐tetrachlorodibenzo‐ p ‐dioxin (TCDD) exposure increases morbidity mortality from chronic cardiovascular diseases, including However, whether how TCDD causes endothelial remains largely unknown. Cultured human umbilical vein cells (HUVECs) were exposed to different doses TCDD, cell apoptosis was examined. We found treatment...
Nonsteroidal anti-inflammatory drugs (NSAIDs), including acetylsalicylic acid (ASA), improve glucose metabolism in diabetic subjects, although the underlying mechanisms remain unclear. In this study, we observed dysregulated expression of cyclooxygenase-2, prostacyclin biosynthesis, and I prostanoid receptor (IP) liver's response to stresses. High doses ASA reduced hepatic prostaglandin generation suppressed gluconeogenesis mice during fasting, hypoglycemic effect could be restored by IP...
Background: Geniposide (GE) is the main component in gardenia fruit. This study aimed to investigate protective effects and potential mechanisms of GE on dextran sulfate sodium (DSS)-induced colitis mice lipopolysaccharide (LPS)-induced RAW 264.7 cells. Methods: The vivo acute experimental model was established by administering drinking water containing 3% DSS for 7 days. administered via oral gavage at 20 40 mg/kg Colon length, colon myeloperoxidase (MPO) level, serum malondialdehyde (MDA)...
Prostaglandin E 2 (PGE ) is an important lipid mediator of inflammation. However, whether and how PGE regulates hepatic cholesterol metabolism remains unknown. We found that expression the receptor, prostanoid receptor 3 (EP3) remarkably increased in hepatocytes response to hyperlipidemic stress. Hepatocyte‐specific deletion EP3 ( hep–/– results hypercholesterolemia augments diet‐induced atherosclerosis low‐density lipoprotein knockout Ldlr –/– mice. Cholesterol 7α‐hydroxylase (CYP7A1)...
Autologous adipose-derived stromal cells (ASCs) offer great promise as angiogenic cell therapy for ischemic diseases. Because of their limited self-renewal capacity and pluripotentiality, the therapeutic efficacy ASCs is still relatively low. Thromboxane has been shown to play an important role in maintenance vascular homeostasis. However, little known about effects thromboxane on ASC-mediated angiogenesis.To explore thromboxane-prostanoid receptor (TP) mediating vivo.ASCs were prepared from...
BACKGROUND Pancreatic cancer is a highly malignant disease. After decades of treatment progress, the current five-year survival rate for patients still less than 10%. For later-line treatment, options are even more limited. Anti-angiogenic drugs can improve progression-free in with advanced pancreatic cancer. Preclinical data show that fruquintinib might prognosis by targeting angiogenesis and lymphopoiesis, improving abnormal vascular structure, modulating tumour immune microenvironment....
Abstract Prostanoids are endogenous lipid bioactive mediators that play essential roles in physiological processes such as glucocorticoid secretion. Here, it is found the thromboxane (Tx)A 2 receptor (TP) highly expressed adrenal cortex of mice. Both global and adrenocortical‐specific deletion TP lead to increased adiposity mice by elevating corticosterone synthesis. Mechanistically, increases phosphorylation steroidogenic acute regulatory protein (StAR) synthesis cortical cells suppressing...