A5100349110- Pulmonary Hypertension Research and Treatments
- Cancer-related molecular mechanisms research
- PI3K/AKT/mTOR signaling in cancer
- Circular RNAs in diseases
- ATP Synthase and ATPases Research
- Lung Cancer Treatments and Mutations
- Venous Thromboembolism Diagnosis and Management
- MicroRNA in disease regulation
- Hippo pathway signaling and YAP/TAZ
- Autophagy in Disease and Therapy
- Ferroptosis and cancer prognosis
- Sphingolipid Metabolism and Signaling
- Ubiquitin and proteasome pathways
- Epigenetics and DNA Methylation
- RNA modifications and cancer
- Protease and Inhibitor Mechanisms
- Mitochondrial Function and Pathology
- dental development and anomalies
- Renal cell carcinoma treatment
- Endodontics and Root Canal Treatments
- Kruppel-like factors research
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Inflammatory Biomarkers in Disease Prognosis
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Cell Adhesion Molecules Research
Shaanxi Provincial People's Hospital
2025
Shanxi Medical University
2025
First Affiliated Hospital of Xi'an Jiaotong University
2017-2024
Shanxi University
2024
Xi'an Jiaotong University
2021-2023
Shanghai Jiao Tong University
2022-2023
Ruijin Hospital
2023
Shenzhen University
2023
Qingdao University
2023
Wenzhou Medical University
2018-2023
Abstract Objectives High‐mobility group box‐1 (HMGB1) and aberrant mitochondrial fission mediated by excessive activation of GTPase dynamin‐related protein 1 (Drp1) have been found to be elevated in patients with pulmonary arterial hypertension (PAH) critically implicated PAH pathogenesis. However, it remains unknown whether Drp1‐mediated which downstream targets mediate HMGB1‐induced smooth muscle cells (PASMCs) proliferation migration leading vascular remodelling PAH. This study aims...
Abstract Alcohol abuse is a significant cause of global morbidity and mortality, with alcoholic liver disease (ALD) being common consequence. The pathogenesis ALD involves various cellular processes, including oxidative stress, inflammation, hepatic cell death. Recently, ferroptosis, an iron-dependent form programmed death, has emerged as potential mechanism in many diseases. However, the specific involvement regulatory mechanisms ferroptosis remain poorly understood. Here we aimed to...
Pulmonary arterial hypertension (PAH) is commonly associated with chronic hypoxemia in disorders such as obstructive pulmonary disease (COPD). Prostacyclin analogs are widely used the management of PAH patients; however, clinical efficacy and long-term tolerability some prostacyclin may be compromised by concomitant activation E-prostanoid 3 (EP3) receptor. Here, we found that EP3 expression upregulated smooth muscle cells (PASMCs) human distal arteries (PAs) response to hypoxia. Either...
The aims of the present study were to examine signaling mechanisms underlying transforming growth factor β1 (TGF-β1)-induced airway smooth muscle cells (ASMCs) proliferation and determine effect adenosine monophosphate-activated protein kinase (AMPK) activation on TGF-β1-induced ASMCs its potential mechanisms. TGF-β1 reduced microRNA-206 (miR-206) level by activating Smad2/3, this in turn up-regulated histone deacetylase 4 (HDAC4) consequently increased cyclin D1 leading proliferation. Prior...
This study aims to investigate the prevalence and morphology of middle mesial canal (MMC) in mandibular first molar (M1M) among a Northwestern Chinese population, analyze their relationship with anatomical aspects root. Cone beam computed tomography (CBCT) was utilized evaluate 898 M1Ms assess incidence MMC. The following parameters for M1M or without MMC were obtained: vertical distance between appearance orifices (D), mesiobuccal (MB) mesiolingual (ML) canals (D1), buccolingual width(L1)...
Studies have indicated that the aggregation of activated platelets with cancer cells facilitates tumor metastasis; adhesion molecule P-selectin may be an important mediator this process, but detailed mechanism is unclear. In current study, we established a B16F10 (B16) cell metastatic model in knockout (P-sel-/-) mice to determine effect P-selectin-mediated platelet on metastasis. Compared C57 mice, P-sel-/- developed fewer foci, and proliferation within tumors was inhibited by deficiency....
This research studies a lung nodule classification problem using 3D computed tomography (CT) images for computer-aided diagnosis (CAD) system by applying deep convolutional neural networks (CNNs). Lung cancer is one of the most common cancers with high mortality rate. There an urgent need to diagnose nodules at early stage improve survival rate patients. Through CAD system, complementary analysis result can be provided radiologists enhance process. The performance conventional systems...
Sphingosine-1-phosphate (S1P), a natural multifunctional phospholipid, is highly increased in plasma from patients with pulmonary arterial hypertension and mediates proliferation of artery smooth muscle cells (PASMCs) by activating the Notch3 signaling pathway. However, mechanisms underpinning S1P-mediated induction PASMCs remain unclear. In this study, using biochemical molecular biology approaches, RNA interference gene expression analyses, 5′-ethynyl-2′-deoxyuridine incorporation assay,...
Abstract Background Macrophage migration inhibitory factor (MIF) and GTPase dynamin-related protein 1 (Drp1)-dependent aberrant mitochondrial fission are closely linked to the pathogenesis of asthma. However, it is unclear whether Drp1-mediated its downstream targets mediate MIF-induced proliferation airway smooth muscle cells (ASMCs) in vitro remodeling chronic asthma models. The present study aims clarify these issues. Methods In this study, primary cultured ASMCs ovalbumin (OVA)-induced...
The effects of luteolin on the proliferation A549 cells were evaluated by MTT and clone formation assays. DNA ploidy apoptotic cell percentage calculated flow cytometry. expression Bax, Bcl-xl, Bcl-2, Mcl-1, caspase-9, caspase-3, PARP was analyzed Western blotting. membrane potential mitochondria detected JC-1 fluorescence microscopy assay. Our results demonstrated that could inhibit via induction apoptosis, with evidence characteristic morphological changes apoptosis in nucleus....
Leucocyte adhesion to the vascular endothelium is a critical event in early inflammatory response infection and injury. This process primarily regulated by expression of cell molecules (CAMs) endothelial cells. It has been well documented that tumor necrosis factor alpha (TNF-α) key regulator CAM within this process, but its regulatory mechanism remains controversial. To investigate scenario we assessed role zipper-interacting protein kinase (ZIPK), serine/threonine with multiple substrates,...
Background/Aims: The underlying molecular mechanisms involved in sphingosine kinase 1 (SphK1)/sphingosine 1-phosphate (S1P) mediation of platelet-derived growth factor (PDGF)-induced pulmonary arterial smooth muscle cell (PASMC) proliferation are still unclear, and the present study aims to address this issue. Methods: Small interfering RNA (siRNA) microRNA inhibitor transfection was performed block expression SphK1, bone morphogenetic protein receptor II (BMPRII) microRNA-21 (miR-21). Gene...
The upregulation of osteopontin(OPN) has been found to contribute the proliferation pulmonary artery smooth muscle cells(PASMCs), and activation PPARγ shown suppress OPN expression in THP-1 cells. However, molecular mechanisms underlying agonist modulation PASMCs remain largely unclear. Here we that S1P stimulated up-regulated rat PASMCs, which was accompanied with phospholipase C(PLC), calcineurin translocation NFATc3 nucleus. Further study showed inhibition PLC by U73122, suppression...
Abstract Gastric cancer (GC), a common gastrointestinal malignancy worldwide, has poor prognosis and frequent recurrence. There is great need to identify effective therapy for GC. Crizotinib multi-targeted, clinically available oral tyrosine kinase inhibitor approved lung cancer, but its use the highly heterogeneous disease of GC unknown. The goal this study was investigate anti-cancer mechanisms (S)-crizotinib in inhibiting growth. Human cell lines (SGC-7901 BGC-823)...
Chronic obstructive pulmonary disease (COPD) is a common chronic disease. Progression further exacerbated by the coexistence of cardiovascular (CVD). We aim to construct diagnostic nomogram for predicting risk coexisting CVD and prognostic long-term survival in COPD.The 540 eligible participants selected from NHANES 2005-2010 were included this study. Logistic regression analysis was used diagnosis COPD. Cox analyses A stratification system developed based on total score generated nomogram....
The expression of micro RNA (miR)‐140‐5p is known to be reduced in both pulmonary arterial hypertension ( PAH ) patients and monocrotaline‐induced models rat. Identification target genes for miR‐140‐5p with bioinformatics analysis may reveal new pathways connections . This study aimed explore downstream relevant signaling regulated by provide theoretical evidences further researches on role Multiple upstream transcription factors TF s) were predicted the analysis. Gene ontology GO enrichment...
At present, the research on clear aligner of molar distalization mainly focuses upper jaw, while mandibular molars is few.This study aims to evaluate therapeutic effect with via cone beam CT (CBCT) and Dolphin software.
An aneurysm is an inflammatory vascular condition. Phosphatidylinositol 3-kinases δ highly expressed in leukocytes, and play a key role innate immunity. However, the link between phosphatidylinositol development has not yet been elucidated.Carotid ligation unexpectedly induced characteristic formation beneath point p110δ(D910A/D910A) mice (n=25; P<0.001 versus wild-type). Besides, p110δ inactivation exacerbated CaCl2-induced abdominal aortic aneurysms development. A reverse transcription...